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Deletion of SDF-1 or CXCR4 regulates platelet activation linked to glucose metabolism and mitochondrial respiratory reserve.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9208117 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1635 (Electronic) Linking ISSN: 09537104 NLM ISO Abbreviation: Platelets Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Edinburgh ; New York : Churchill Livingstone, c1990-
    • الموضوع:
      Chemokine CXCL12*/genetics ; Chemokine CXCL12*/metabolism ; Thrombin*; Adenosine Triphosphate ; Glucose/pharmacology ; Humans ; Mitochondria/metabolism ; Platelet Activation ; Receptors, CXCR4/genetics
    • نبذة مختصرة :
      Stromal cell-derived factor 1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have shown to play a role in the homing and engraftment of hematopoietic stem and progenitor cells. SDF-1 is highly expressed in platelets and involved in thrombosis formation. However, the exact roles of platelet-derived SDF-1 and CXCR4 in platelet activation and mitochondrial function have not been revealed yet. Deletion of Sdf-1 and Cxcr4 specifically in platelets decreased agonist-induced platelet aggregation and dramatically impaired thrombin-induced glucose uptake. In SDF-1-deficient and CXCR4-deficient platelets, intracellular ATP secretions were reduced when activated by the addition of thrombin. SDF-1 deficiency in platelets can impair the routine respiration during resting state and maximal capacity of the electron transfer system (ETS) during activated state. Mitochondrial respiration measurements in permeabilized platelets indicated an impaired function of the oxidative phosphorylation system in -SDF-1 or CXCR4-deficient platelets. These results suggested a novel role of the SDF-1/CXCR4 axis in modulating platelet energy metabolism and activation by regulating mitochondrial respiration, glucose uptake, and ATP production.
    • Contributed Indexing:
      Keywords: CXCR4; Platelets; SDF-1; glucose metabolism; mitochondrial respiration
    • الرقم المعرف:
      0 (CXCR4 protein, human)
      0 (Chemokine CXCL12)
      0 (Receptors, CXCR4)
      8L70Q75FXE (Adenosine Triphosphate)
      EC 3.4.21.5 (Thrombin)
      IY9XDZ35W2 (Glucose)
    • الموضوع:
      Date Created: 20210804 Date Completed: 20220426 Latest Revision: 20220426
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1080/09537104.2021.1961713
    • الرقم المعرف:
      34346843