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Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Prognosis*; Angiopoietin-1/*blood ; Angiopoietin-2/*blood ; Biomarkers/*blood ; Hypertension, Pulmonary/*blood ; Hypertension, Pulmonary/*diagnosis; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Endothelial Cells/metabolism ; Female ; Gene Expression Regulation ; Humans ; Idiopathic Pulmonary Fibrosis/blood ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Treatment Outcome ; Vascular Resistance
    • نبذة مختصرة :
      Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n = 32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n = 75), and age-matched healthy controls (HC, n = 60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p = 0.025) and in patients with IPF without PH (p = 0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r = 0.769, p < 0.001), right ventricular diameter on echocardiography (r = 0.565, p = 0.035), and mean pulmonary arterial pressure (r = 0.449, p = 0.032) and pulmonary vascular resistance (r = 0.451, p = 0.031) on right-heart catheterization. ANGP-1 and ANGP-2 were expressed on lung vascular endothelial cells, as shown by immunohistochemistry. Patients with PH with higher ANGP-2 concentration (≥ 2.48 ng/mL) had significantly worse survival (p = 0.022). Higher ANGP-2 concentration was a significant worse prognostic factor (hazard ratio = 6.063, p = 0.037), while serum ANGP-1 concentration was not. In conclusion, serum ANGP-2 may be a useful diagnostic and prognostic biomarker in patients with PH, especially in patients with group 3 PH.
      (© 2021. The Author(s).)
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    • الرقم المعرف:
      0 (ANGPT1 protein, human)
      0 (ANGPT2 protein, human)
      0 (Angiopoietin-1)
      0 (Angiopoietin-2)
      0 (Biomarkers)
    • الموضوع:
      Date Created: 20210730 Date Completed: 20211213 Latest Revision: 20211214
    • الموضوع:
      20240628
    • الرقم المعرف:
      PMC8322335
    • الرقم المعرف:
      10.1038/s41598-021-94907-w
    • الرقم المعرف:
      34326408