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Novel Bradykinin Receptor Inhibitors Inhibit Proliferation and Promote the Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the ERK Pathway.
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- معلومة اضافية
- المصدر:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI, c1995-
- الموضوع:
- نبذة مختصرة :
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Studies have shown that bradykinin (BK) is highly expressed in liver cancer. We designed the novel BK receptor inhibitors J051-71 and J051-105, which reduced the viability of liver cancer cells and inhibited the formation of cancer cell colonies. J051-71 and J051-105 reduced cell proliferation and induced apoptosis in HepG2 and BEL-7402 cells, which may be due to the inhibition of the extracellular regulated protein kinase (ERK) signaling pathway. In addition, these BK receptor inhibitors reversed the cell proliferation induced by BK in HepG2 and BEL-7402 cells by downregulating B1 receptor expression. Inhibiting B1 receptor expression decreased the protein levels of p-ERK and reduced the malignant progression of HCC, providing a potential target for HCC therapy.
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- Grant Information:
20180101250 JC Natural Science Foundation of Jilin Province; JJKH20180178 KJ "13th Five-Year" Science and Technology Project of Jilin Provincial Department of Education
- Contributed Indexing:
Keywords: ERK signaling pathway; apoptosis; bradykinin B1 receptor; bradykinin receptor inhibitor; hepatocellular carcinoma
- الرقم المعرف:
0 (Antineoplastic Agents)
0 (Bradykinin Receptor Antagonists)
EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
- الموضوع:
Date Created: 20210702 Date Completed: 20210721 Latest Revision: 20210721
- الموضوع:
20231215
- الرقم المعرف:
PMC8272207
- الرقم المعرف:
10.3390/molecules26133915
- الرقم المعرف:
34206871
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