Breast Cancer: Targeting of Steroid Hormones in Cancerogenesis and Diagnostics.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Androstenedione/*blood ; Breast Neoplasms/*diagnosis ; Dehydroepiandrosterone/*blood ; Dihydrotestosterone/*blood ; Estradiol/*blood ; Estrone/*analogs & derivatives; Biomarkers, Tumor/blood ; Breast Neoplasms/blood ; Breast Neoplasms/pathology ; Estrone/blood ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Immunoassay ; Metabolic Networks and Pathways ; Metabolomics/instrumentation ; Metabolomics/methods ; Recurrence ; Tandem Mass Spectrometry

Breast cancer is the most common malignancy in women with high mortality. Sensitive and specific methods for the detection, characterization and quantification of endogenous steroids in body fluids or tissues are needed for the diagnosis, treatment and prognosis of breast cancer and many other diseases. At present, non-invasive diagnostic methods are gaining more and more prominence, which enable a relatively fast and painless way of detecting many diseases. Metabolomics is a promising analytical method, the principle of which is the study and analysis of metabolites in biological material. It represents a comprehensive non-invasive diagnosis, which has a high potential for use in the diagnosis and prognosis of cancers, including breast cancer. This short review focuses on the targeted metabolomics of steroid hormones, which play an important role in the development and classification of breast cancer. The most commonly used diagnostic tool is the chromatographic method with mass spectrometry detection, which can simultaneously determine several steroid hormones and metabolites in one sample. This analytical procedure has a high potential in effective diagnosis of steroidogenesis disorders. Due to the association between steroidogenesis and breast cancer progression, steroid profiling is an important tool, as well as in monitoring disease progression, improving prognosis, and minimizing recurrence.

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Keywords: breast cancer; metabolomics; steroid hormones

0 (Biomarkers, Tumor)
08J2K08A3Y (Dihydrotestosterone)
2DI9HA706A (Estrone)
409J2J96VR (Androstenedione)
459AG36T1B (Dehydroepiandrosterone)
4TI98Z838E (Estradiol)
QTL48N278K (estrone sulfate)

Date Created: 20210602 Date Completed: 20210623 Latest Revision: 20210623

20221213

PMC8199112

10.3390/ijms22115878

34070921