Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Anorexia Nervosa/*pathology ; Cardiovascular Abnormalities/*pathology ; Peripheral Vascular Diseases/*pathology; Anorexia Nervosa/complications ; Anorexia Nervosa/immunology ; Anorexia Nervosa/metabolism ; Cardiovascular Abnormalities/complications ; Cardiovascular Abnormalities/immunology ; Cardiovascular Abnormalities/metabolism ; Heart Rate/physiology ; Humans ; Immune System/pathology ; Neurosecretory Systems/metabolism ; Neurosecretory Systems/pathology ; Peripheral Vascular Diseases/complications ; Peripheral Vascular Diseases/immunology ; Peripheral Vascular Diseases/metabolism ; Vagus Nerve/metabolism ; Vagus Nerve/pathology

Immune, neuroendocrine, and autonomic nervous system dysregulation in anorexia nervosa lead to cardiovascular complications that can potentially result in increased morbidity and mortality. It is suggested that a complex non-invasive assessment of cardiovascular autonomic regulation-cardiac vagal control, sympathetic vascular activity, and cardiovascular reflex control-could represent a promising tool for early diagnosis, personalized therapy, and monitoring of therapeutic interventions in anorexia nervosa particularly at a vulnerable adolescent age. In this view, we recommend to consider in the diagnostic route, at least in the subset of patients with peripheral microvascular symptoms, a nailfold video-capillaroscopy as an easy not invasive tool for the early assessing of possible cardiovascular involvement.

Radiat Res. 2020 Mar;193(3):236-240. (PMID: 31877253)
Mol Metab. 2020 Sep;39:101022. (PMID: 32446877)
Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S123-6. (PMID: 26242276)
Mol Psychiatry. 2019 Jun;24(6):901-915. (PMID: 30353170)
J Rheumatol. 2010 Jun;37(6):1168-73. (PMID: 20436078)
Clin Sci (Lond). 1981 Nov;61(5):559-67. (PMID: 7285502)
Arthritis Rheumatol. 2021 Nov;73(11):2146. (PMID: 33982882)
J Clin Med. 2019 Apr 26;8(5):. (PMID: 31027378)
Curr Cardiovasc Risk Rep. 2012 Feb;6(1):80-90. (PMID: 22247785)
Int J Environ Res Public Health. 2020 Jun 12;17(12):. (PMID: 32545690)
Arthritis Rheumatol. 2018 Sep;70(9):1489-1499. (PMID: 29569858)
Microvasc Res. 2021 Mar;134:104122. (PMID: 33316334)
Int J Mol Sci. 2020 Feb 13;21(4):. (PMID: 32069819)
Pediatrics. 2017 Dec;140(6):. (PMID: 29122972)
Ann N Y Acad Sci. 1998 Sep 29;856:160-170. (PMID: 9917876)
Pediatrics. 2017 Dec;140(6):. (PMID: 29122974)
Autoimmun Rev. 2021 Oct;20(10):102905. (PMID: 34274544)
Eur Eat Disord Rev. 2021 Jan;29(1):20-31. (PMID: 32975349)
Gut. 2018 Feb;67(2):271-283. (PMID: 28377388)
Front Immunol. 2018 Sep 06;9:2031. (PMID: 30237802)
QJM. 2019 Jul 1;112(7):531-533. (PMID: 31028378)
Brain Behav Immun. 2020 Aug;88:718-724. (PMID: 32389698)
Adv Genomics Genet. 2015;5:131-150. (PMID: 27013903)
Int J Mol Sci. 2020 Mar 27;21(7):. (PMID: 32230840)
Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):200-206. (PMID: 27494080)
Clin Rheumatol. 2019 Sep;38(9):2343-2354. (PMID: 31278512)
Swiss Med Wkly. 2017 Oct 04;147:w14506. (PMID: 28975961)
Int J Eat Disord. 2015 Sep;48(6):615-21. (PMID: 25808182)
Front Neurosci. 2021 Mar 23;15:616883. (PMID: 33833660)
Clin Rheumatol. 2014 Nov;33(11):1627-33. (PMID: 24615537)
Scand J Rheumatol. 2021 Mar;50(2):153-160. (PMID: 33063580)
Nutr J. 2019 Dec 26;18(1):89. (PMID: 31878925)
Clin Exp Rheumatol. 2017 Sep-Oct;35(5):739-745. (PMID: 28770704)
Front Neurosci. 2010 Jan 08;3:59. (PMID: 20582290)
Bone. 2021 Mar;144:115824. (PMID: 33359891)
Int J Mol Sci. 2020 Nov 24;21(23):. (PMID: 33255179)
Bratisl Lek Listy. 2013;114(11):634-6. (PMID: 24236432)
Eur J Clin Invest. 2015 Jul;45(7):670-8. (PMID: 25944525)
J Neuroinflammation. 2013 Apr 01;10:43. (PMID: 23547920)
Front Psychol. 2019 Oct 29;10:2200. (PMID: 31749720)
Curr Opin Psychiatry. 2020 Nov;33(6):515-520. (PMID: 32576735)
Psychoneuroendocrinology. 2015 Jan;51:237-52. (PMID: 25462897)
Semin Immunopathol. 2015 Sep;37(5):489-500. (PMID: 26152638)
Int J Mol Sci. 2020 Oct 02;21(19):. (PMID: 33023273)
JAMA. 2018 Jun 19;319(23):2388-2400. (PMID: 29922828)
Microvasc Res. 2020 Nov;132:104040. (PMID: 32768463)
Am J Psychiatry. 2017 Sep 1;174(9):850-858. (PMID: 28494655)
Annu Rev Immunol. 2018 Apr 26;36:783-812. (PMID: 29677475)
PLoS One. 2014 Aug 22;9(8):e104845. (PMID: 25147950)
Nat Rev Gastroenterol Hepatol. 2012 Mar 06;9(5):286-94. (PMID: 22392290)
Biopsychosoc Med. 2015 Apr 23;9:12. (PMID: 25908939)
Nutrients. 2020 Oct 28;12(11):. (PMID: 33126427)
Eur Heart J. 2010 May;31(9):1142-8. (PMID: 20181680)
Ann N Y Acad Sci. 2019 Feb;1437(1):31-42. (PMID: 29762862)
J Physiol Sci. 2015 Sep;65(5):385-95. (PMID: 26123258)
Eur J Prev Cardiol. 2021 Aug 9;28(9):e6-e7. (PMID: 32539449)
Autoimmun Rev. 2017 Aug;16(8):774-786. (PMID: 28572048)
Sci Rep. 2021 Jan 13;11(1):1125. (PMID: 33441933)
Front Physiol. 2012 Jul 24;3:284. (PMID: 22934037)
N Engl J Med. 2020 Apr 2;382(14):1343-1351. (PMID: 32242359)
Heart Fail Rev. 2014 Sep;19(5):681-94. (PMID: 24005868)
Front Immunol. 2018 Sep 07;9:2045. (PMID: 30245695)
Appl Physiol Nutr Metab. 2020 Jan;45(1):81-90. (PMID: 31163115)
J Child Psychol Psychiatry. 2019 Jul;60(7):803-812. (PMID: 30178543)
Nature. 2014 Dec 11;516(7530):246-9. (PMID: 25274309)
Minerva Endocrinol. 2013 Sep;38(3):255-67. (PMID: 24126546)
J Cell Mol Med. 2018 Jul;22(7):3308-3314. (PMID: 29664231)
Biomed Res Int. 2015;2015:974530. (PMID: 26421308)
Clin Hemorheol Microcirc. 2020;74(3):281-285. (PMID: 31322553)
Nutrients. 2019 Aug 23;11(9):. (PMID: 31450770)
Nutrients. 2020 Dec 02;12(12):. (PMID: 33276482)
Eur Psychiatry. 2020 Dec 16;64(1):e2. (PMID: 33416044)
Int J Mol Sci. 2018 Apr 13;19(4):. (PMID: 29652832)
Curr Med Res Opin. 2018 Mar;34(3):547-550. (PMID: 29292666)
Best Pract Res Clin Rheumatol. 2020 Feb;34(1):101474. (PMID: 32007400)
Nat Rev Immunol. 2021 Jan;21(1):20-36. (PMID: 32811994)
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):392-394. (PMID: 28559592)
Int J Med Sci. 2011;8(8):679-703. (PMID: 22135615)

Keywords: anorexia nervosa; autoimmunity; capillaroscopy; cardiovascular diseases; cytokines; eating disorders; microcirculation; microvascular damage; nailfoldcapillaroscopy; neuroendocrine dysregulation

Date Created: 20210602 Date Completed: 20210615 Latest Revision: 20240402

20240402

PMC8126077

10.3390/ijms22095043

34068698