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Genetic polymorphisms of Cathepsin B are associated with gastric cancer risk and prognosis in a Chinese population.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101256509 Publication Model: Print Cited Medium: Internet ISSN: 1875-8592 (Electronic) Linking ISSN: 15740153 NLM ISO Abbreviation: Cancer Biomark Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Amsterdam ; Washington, DC : IOS Press, c2005-
    • الموضوع:
      Genetic Predisposition to Disease*; Biomarkers, Tumor/*genetics ; Cathepsin B/*genetics ; Stomach Neoplasms/*genetics; Aged ; Asian People/genetics ; Case-Control Studies ; China/epidemiology ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Polymorphism, Single Nucleotide ; Prognosis ; Stomach/pathology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology
    • نبذة مختصرة :
      Background: Genetic polymorphisms are believed to represent a key aspect of predisposition to gastric cancer (GC). Therefore, considering the important role of Cathepsin B (CTSB) in promoting cancer onset and development, it could be very worthful to explore the function of CTSB-related genetic polymorphisms in GC.
      Objective: In this study, we investigated the correlation of CTSB-related polymorphisms (rs9009A>T, rs6731T>C, rs1293303G>C, rs1874547C>T, rs3779659C>T, rs17814426C>T and rs148669985C>T) with GC risk and prognosis in a case-control study of 994 cases and 1000 controls.
      Methods: All tag single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-ligase detection reaction (PCR-LDR) sequencing technology.
      Results: The results indicated rs9009, rs6731 and rs17814426 correlated with decreased risks of GC (HR = 0.97, p< 0.001; HR = 0.86, P= 0.019; HR = 0.85, P= 0.017; respectively). Stratification analysis further showed rs17814426 variant genotypes correlated with earlier T stage (p= 0.044). In addition, GC patients carrying the C allele of rs6371 had better overall prognosis (HR = 0.62, 95%CI = 0.44-0.88).
      Conclusion: Our results firstly suggested the importance of CTSB-related polymorphisms on GC which could predict GC risk and prognosis.
    • Contributed Indexing:
      Keywords: Cathepsin B; Gastric cancer; Polymorphism; Prognosis; Susceptibility
    • الرقم المعرف:
      0 (Biomarkers, Tumor)
      EC 3.4.22.1 (CTSB protein, human)
      EC 3.4.22.1 (Cathepsin B)
    • الموضوع:
      Date Created: 20210531 Date Completed: 20220201 Latest Revision: 20221207
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.3233/CBM-203208
    • الرقم المعرف:
      34057136