Protein Phosphorylation Signaling Cascades in Autism: The Role of mTOR Pathway.

Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE

Publication: <2007->: Moscow : MAIK Nauka/Interperiodica
Original Publication: New York, Consultants Bureau [etc.]

Signal Transduction*; Autistic Disorder/*metabolism ; TOR Serine-Threonine Kinases/*metabolism; Autism Spectrum Disorder/metabolism ; Humans ; Phosphorylation ; Protein Processing, Post-Translational

The mammalian target of rapamycin (mTOR) signaling pathway is a central regulator of cell metabolism, growth, and survival in response to hormones, growth factors, nutrients, and stress-induced signals. In this review, we analyzed the studies on the molecular abnormalities of the mTOR-associated signaling cascades in autism spectrum disorders (ASDs) and outlined the prospects for the pathogenicity-targeting pharmacotherapeutic approaches to ASDs, in particular syndromic ASDs. Based on available experimental and clinical data, we suggest that very early detection of molecular abnormalities in the ASD risk groups can be facilitated by using peripheral blood platelets. Also, identification of the time window of critical dysregulations in the described pathways in the ASD risk groups might suggest further research directions leading to more efficacious pharmacotherapeutic interventions in ASDs.

Keywords: autism spectrum disorders; mTOR; protein phosphorylation; signaling cascades

EC 2.7.1.1 (MTOR protein, human)
EC 2.7.11.1 (TOR Serine-Threonine Kinases)

Date Created: 20210517 Date Completed: 20210709 Latest Revision: 20211204

20250114

10.1134/S0006297921050072

33993859