Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- معلومة اضافية
- المصدر:
Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : BioMed Central, 2003-
- الموضوع:
- نبذة مختصرة :
Increasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to make up 50-80% of all cases. AD cases are expected to reach 131 million by 2050, and this increasing prevalence will critically burden economies and health systems in the next decades. There is currently no treatment that can stop or reverse disease progression. In addition, the late diagnosis of AD constitutes a major obstacle to effective disease management. Therefore, improved diagnostic tools and new treatments for AD are urgently needed. In this review, we investigate and describe both well-established and recently discovered AD biomarkers that could potentially be used to detect AD at early stages and allow the monitoring of disease progression. Proteins such as NfL, MMPs, p-tau217, YKL-40, SNAP-25, VCAM-1, and Ng / BACE are some of the most promising biomarkers because of their successful use as diagnostic tools. In addition, we explore the most recent molecular strategies for an AD therapeutic approach and nanomedicine-based technologies, used to both target drugs to the brain and serve as devices for tracking disease progression diagnostic biomarkers. State-of-the-art nanoparticles, such as polymeric, lipid, and metal-based, are being widely investigated for their potential to improve the effectiveness of both conventional drugs and novel compounds for treating AD. The most recent studies on these nanodevices are deeply explained and discussed in this review.
- References:
JAMA Neurol. 2019 Jul 1;76(7):791-799. (PMID: 31009028)
Neurobiol Dis. 2015 Oct;82:593-606. (PMID: 26311408)
J Neurosci Methods. 2019 May 1;319:2-6. (PMID: 30352211)
J Neuroinflammation. 2020 May 28;17(1):168. (PMID: 32466767)
Neurol Clin. 2017 May;35(2):263-281. (PMID: 28410659)
Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18. (PMID: 19782542)
Cell Mol Neurobiol. 2018 Jul;38(5):965-980. (PMID: 29299792)
Alzheimers Dement. 2018 Apr;14(4):535-562. (PMID: 29653606)
EMBO Mol Med. 2020 Sep 7;12(9):e12308. (PMID: 32790063)
J Exp Med. 2020 Nov 2;217(11):. (PMID: 32725127)
Expert Rev Neurother. 2017 Jan;17(1):47-57. (PMID: 27332958)
Rev Neurol. 2006 Apr 16-30;42(8):471-7. (PMID: 16625509)
J Alzheimers Dis. 2015;43(1):37-45. (PMID: 25079796)
Front Aging Neurosci. 2019 Aug 30;11:233. (PMID: 31543810)
Cells. 2019 Mar 11;8(3):. (PMID: 30862089)
Int J Alzheimers Dis. 2012;2012:578373. (PMID: 22675648)
Neuroscience. 2018 Feb 1;370:181-190. (PMID: 28729061)
Lancet Neurol. 2016 Jun;15(7):673-684. (PMID: 27068280)
ACS Chem Neurosci. 2013 Apr 17;4(4):575-84. (PMID: 23590250)
Nat Rev Drug Discov. 2020 Jul;19(7):444. (PMID: 32504057)
Acta Biomater. 2016 Dec;46:177-190. (PMID: 27619837)
J Inflamm Res. 2016 Nov 03;9:199-208. (PMID: 27843334)
Curr Pharm Des. 2020;26(12):1316-1330. (PMID: 31951159)
Alzheimers Dement (N Y). 2020 Jul 16;6(1):e12050. (PMID: 32695874)
J Control Release. 2019 May 10;301:62-75. (PMID: 30876953)
BMC Neurol. 2020 Jan 9;20(1):10. (PMID: 31918679)
Lancet Neurol. 2019 Jan;18(1):88-106. (PMID: 30497964)
Brain Res Mol Brain Res. 1996 Feb;36(1):145-51. (PMID: 9011750)
Colloids Surf B Biointerfaces. 2020 Jun;190:110948. (PMID: 32160583)
Alzheimers Dement. 2017 Jul;13(7):810-827. (PMID: 28242299)
BMB Rep. 2020 Jan;53(1):47-55. (PMID: 31818365)
Aging Dis. 2016 Mar 15;7(2):201-14. (PMID: 27114851)
Alzheimers Res Ther. 2016 Oct 3;8(1):41. (PMID: 27716408)
PLoS One. 2016 Jul 26;11(7):e0159099. (PMID: 27459603)
JAMA. 2020 Aug 25;324(8):772-781. (PMID: 32722745)
Alzheimers Dement. 2019 May;15(5):644-654. (PMID: 30853464)
Nat Commun. 2020 Feb 10;11(1):812. (PMID: 32041951)
Alzheimers Dement (N Y). 2018 Nov 10;4:617-627. (PMID: 30519627)
Brain Res. 1996 Dec 2;742(1-2):299-304. (PMID: 9117408)
Alzheimers Dement. 2014 Oct;10(5 Suppl):S425-S429.e1. (PMID: 24239250)
Molecules. 2017 Apr 20;22(4):. (PMID: 28425969)
Int Rev Neurobiol. 2017;137:1-28. (PMID: 29132540)
J Alzheimers Dis. 2018;61(4):1323-1332. (PMID: 29376870)
Nanomaterials (Basel). 2020 Feb 09;10(2):. (PMID: 32050443)
J Alzheimers Dis. 2016;52(2):731-45. (PMID: 27031484)
Mol Chem Neuropathol. 1996 Feb;27(2):195-210. (PMID: 8962603)
Pharmacol Res. 2019 Jul;145:104255. (PMID: 31075308)
Alzheimers Res Ther. 2020 Jan 2;12(1):3. (PMID: 31898549)
AAPS J. 2013 Jan;15(1):195-218. (PMID: 23143785)
Int J Biol Macromol. 2020 Jan 1;142:265-276. (PMID: 31593732)
Int J Pharm. 2008 Dec 8;364(2):298-327. (PMID: 18621492)
Alzheimers Res Ther. 2018 Aug 16;10(1):80. (PMID: 30115118)
Int J Pharm. 2020 Aug 30;586:119553. (PMID: 32561306)
Mol Cell Neurosci. 2019 Jun;97:18-33. (PMID: 30529601)
Arch Neurol. 2009 Mar;66(3):300-5. (PMID: 19273747)
Ann Clin Transl Neurol. 2016 Jan 01;3(3):154-65. (PMID: 27042676)
J Neurosci Res. 2001 Nov 1;66(3):510-6. (PMID: 11746370)
J Alzheimers Dis. 2011;25(2):373-81. (PMID: 21460439)
Ther Adv Neurol Disord. 2019 Dec 18;12:1756286419888819. (PMID: 31897088)
Alzheimers Dement. 2019 Jan;15(1):55-64. (PMID: 30321501)
Nat Biotechnol. 2011 Apr;29(4):341-5. (PMID: 21423189)
J Alzheimers Dis. 2017;57(4):975-999. (PMID: 27567878)
Nat Med. 2019 Feb;25(2):270-276. (PMID: 30643288)
Int J Alzheimers Dis. 2012;2012:737846. (PMID: 22655214)
Front Aging Neurosci. 2018 Jul 09;10:202. (PMID: 30038567)
Dialogues Clin Neurosci. 2003 Mar;5(1):101-8. (PMID: 22034141)
J Pharm Pharmacol. 2005 Mar;57(3):273-85. (PMID: 15807982)
Anal Chim Acta. 2020 Apr 8;1105:147-154. (PMID: 32138913)
J Colloid Interface Sci. 2019 Sep 15;552:388-400. (PMID: 31151017)
Nature. 2017 Jun 21;546(7659):564. (PMID: 28640269)
J Neurol Sci. 2016 Feb 15;361:256-71. (PMID: 26810552)
Brain. 2018 Jul 1;141(7):1917-1933. (PMID: 29850777)
Brain Res Bull. 2016 Sep;126(Pt 3):238-292. (PMID: 27615390)
Curr Alzheimer Res. 2016;13(6):654-62. (PMID: 26971930)
Nanomedicine. 2006 Mar;2(1):8-21. (PMID: 17292111)
Cureus. 2019 May 8;11(5):e4620. (PMID: 31312547)
Ann Clin Transl Neurol. 2015 Mar;2(3):307-23. (PMID: 25815358)
J Pharm Sci. 2014 Jan;103(1):29-52. (PMID: 24338748)
Brain Sci. 2020 Feb 10;10(2):. (PMID: 32050618)
Alzheimers Dement. 2019 Jun;15(6):742-753. (PMID: 30967340)
Int J Mol Sci. 2018 Dec 13;19(12):. (PMID: 30551592)
Cell Mol Life Sci. 2019 May;76(10):1833-1863. (PMID: 30770953)
ACS Omega. 2019 Jul 29;4(7):12833-12840. (PMID: 31460408)
J Control Release. 2020 Apr 10;320:347-362. (PMID: 31978446)
Front Aging Neurosci. 2016 Jul 05;8:160. (PMID: 27458370)
Alzheimers Res Ther. 2019 Dec 1;11(1):96. (PMID: 31787105)
Neurology. 2014 Nov 18;83(21):1945-53. (PMID: 25339208)
Nanomedicine (Lond). 2020 May;15(12):1239-1261. (PMID: 32370600)
Sci Rep. 2018 Apr 11;8(1):5804. (PMID: 29643479)
Biochem Pharmacol. 2014 Apr 15;88(4):508-16. (PMID: 24462903)
Lancet Neurol. 2010 Nov;9(11):1118-27. (PMID: 20934914)
JAMA Neurol. 2016 May 1;73(5):561-71. (PMID: 27018940)
Biomed Rep. 2016 May;4(5):519-522. (PMID: 27123241)
Lancet. 2011 Mar 19;377(9770):1019-31. (PMID: 21371747)
Neuron. 2019 Mar 6;101(5):820-838. (PMID: 30844401)
Int J Biochem Cell Biol. 2012 Apr;44(4):582-6. (PMID: 22265655)
Acta Neuropathol Commun. 2019 Nov 6;7(1):169. (PMID: 31694701)
Nanomedicine (Lond). 2020 Jan;15(2):205-214. (PMID: 31916480)
Neurobiol Aging. 2020 Feb;86:201.e9-201.e14. (PMID: 30797548)
Alzheimers Res Ther. 2019 Feb 20;11(1):19. (PMID: 30786919)
N Engl J Med. 2013 Jan 10;368(2):107-16. (PMID: 23150908)
Mol Membr Biol. 2014 Aug;31(5):152-67. (PMID: 25046533)
J Alzheimers Dis. 2015;46(2):431-40. (PMID: 25790831)
Cells. 2020 Mar 03;9(3):. (PMID: 32138223)
Saudi J Biol Sci. 2020 Jul;27(7):1710-1716. (PMID: 32565686)
Nat Nanotechnol. 2015 Jan;10(1):91-8. (PMID: 25531084)
Biomed Res Int. 2015;2015:484963. (PMID: 26491671)
Transl Neurodegener. 2020 Apr 3;9:10. (PMID: 32266063)
Eur J Pharm Biopharm. 2018 Dec;133:285-308. (PMID: 30463794)
Neurology. 2018 Aug 28;91(9):e859-e866. (PMID: 30068637)
Nanomedicine. 2019 Feb;16:258-266. (PMID: 30300748)
Pharmacol Rep. 2012;64(5):1020-37. (PMID: 23238461)
Biomed Pharmacother. 2016 Mar;78:50-59. (PMID: 26898424)
J Neurochem. 2008 Jul;106(1):392-404. (PMID: 18397369)
Alzheimers Dement. 2018 Aug;14(8):989-997. (PMID: 29626426)
J Alzheimers Parkinsonism Dement. 2016;1(2):. (PMID: 28815226)
Ann N Y Acad Sci. 2001 Jun;939:425-35. (PMID: 11462798)
Food Chem Toxicol. 2018 Nov;121:82-94. (PMID: 30130593)
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4913-7. (PMID: 3088567)
EMBO Mol Med. 2020 Dec 7;12(12):e12921. (PMID: 33169916)
Nanomedicine. 2020 Feb;24:102149. (PMID: 31927133)
Dialogues Clin Neurosci. 2019 Mar;21(1):83-91. (PMID: 31607783)
Nanomedicine. 2020 Aug;28:102226. (PMID: 32479916)
Front Aging Neurosci. 2019 Oct 17;11:282. (PMID: 31680936)
EMBO Mol Med. 2018 Dec;10(12):. (PMID: 30482868)
Transl Neurodegener. 2018 Sep 10;7:23. (PMID: 30311914)
Exp Mol Med. 2020 Apr;52(4):556-568. (PMID: 32284537)
Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70. (PMID: 18655815)
Clin Biochem. 2019 Oct;72:39-51. (PMID: 30953619)
Alzheimers Res Ther. 2020 Mar 16;12(1):25. (PMID: 32178724)
Clin Neurophysiol. 2020 Jun;131(6):1287-1310. (PMID: 32302946)
Nanotechnology. 2015 Dec 11;26(49):495602. (PMID: 26572164)
Food Chem Toxicol. 2020 Feb;136:110962. (PMID: 31734340)
Eur J Neurosci. 2006 Aug;24(3):645-53. (PMID: 16848797)
Int J Pharm. 2017 Aug 7;528(1-2):675-691. (PMID: 28629982)
Neurosci Lett. 2018 Oct 15;685:109-113. (PMID: 30144541)
Nanotechnology. 2019 Dec 13;30(50):502003. (PMID: 31491782)
Am J Clin Pathol. 2008 Apr;129(4):526-9. (PMID: 18343778)
Mol Neurobiol. 2019 Aug;56(8):5792-5798. (PMID: 30680692)
Front Neurol. 2017 Mar 20;8:102. (PMID: 28373857)
Curr Top Med Chem. 2015;15(10):955-69. (PMID: 25832721)
Neurologia. 2016 Sep;31(7):473-81. (PMID: 25023458)
J Inorg Biochem. 2015 Dec;153:1-12. (PMID: 26398431)
Neurochem Int. 2020 Sep;138:104755. (PMID: 32422323)
Biomaterials. 2019 Mar;197:393-404. (PMID: 30703744)
PLoS One. 2018 Mar 5;13(3):e0193707. (PMID: 29505610)
Alzheimers Dement. 2016 Jun;12(6):719-32. (PMID: 27179961)
Int J Nanomedicine. 2017 Apr 18;12:3171-3179. (PMID: 28458538)
Scand J Clin Lab Invest. 1977 Sep;37(5):385-90. (PMID: 337459)
Front Aging Neurosci. 2014 May 20;6:93. (PMID: 24904407)
Biol Psychiatry. 2018 Mar 1;83(5):447-455. (PMID: 28359566)
Adv Clin Exp Med. 2017 Jan-Feb;26(1):23-29. (PMID: 28397428)
Biol Psychiatry. 2018 Feb 15;83(4):377-387. (PMID: 29169609)
J Neuroinflammation. 2007 Feb 11;4:7. (PMID: 17291356)
J Alzheimers Dis. 2015;47(1):17-32. (PMID: 26402751)
Expert Rev Proteomics. 2017 Apr;14(4):285-299. (PMID: 28281838)
Neuropharmacology. 2014 Jan;76 Pt A:27-50. (PMID: 23891641)
Int J Mol Sci. 2018 Jun 27;19(7):. (PMID: 29954063)
J Photochem Photobiol B. 2017 Aug;173:150-164. (PMID: 28582711)
J Alzheimers Dis. 2016 Nov 19;55(2):813-822. (PMID: 27792012)
Alzheimers Dement. 2015 Jan;11(1):58-69. (PMID: 24795085)
Curr Alzheimer Res. 2017;14(11):1140-1148. (PMID: 28164764)
Brain Res. 2019 Oct 15;1721:146325. (PMID: 31325424)
Brain. 2020 Dec 5;143(11):3234-3241. (PMID: 33068398)
Neurobiol Learn Mem. 2019 Dec;166:107082. (PMID: 31493483)
J Prev Alzheimers Dis. 2019;6(1):34-41. (PMID: 30569084)
Alzheimers Dement (N Y). 2019 Feb 26;5:61-69. (PMID: 30859122)
J Neuropathol Exp Neurol. 2001 Aug;60(8):759-67. (PMID: 11487050)
Eur J Pharm Sci. 2020 May 30;148:105314. (PMID: 32200044)
Br J Pharmacol. 2012 Sep;167(2):324-52. (PMID: 22646481)
Lancet Neurol. 2019 Apr;18(4):406-414. (PMID: 30795987)
Biol Psychiatry. 2021 Apr 15;89(8):745-756. (PMID: 32223911)
Alzheimers Dement. 2020 Oct;16(10):1412-1425. (PMID: 32715623)
Nanomedicine. 2019 Apr;17:297-307. (PMID: 30794963)
Saudi Pharm J. 2012 Oct;20(4):331-44. (PMID: 23960808)
Alzheimers Dement (Amst). 2020 Sep 13;12(1):e12099. (PMID: 32995466)
J Control Release. 2015 Dec 10;219:2-7. (PMID: 26456749)
Front Neurosci. 2019 Dec 06;13:1309. (PMID: 31866817)
J Alzheimers Dis. 2010;20(1):253-60. (PMID: 20164582)
Nat Commun. 2019 Mar 25;10(1):1365. (PMID: 30911003)
Int J Pharm. 2010 Apr 15;389(1-2):207-12. (PMID: 20083179)
Mol Neurodegener. 2015 Dec 01;10:64. (PMID: 26627638)
Alzheimers Dement (N Y). 2021 Mar 31;7(1):e12155. (PMID: 33816762)
J Alzheimers Dis. 2016 May 7;53(1):53-67. (PMID: 27163804)
- Grant Information:
PI17/01474 Instituto de Salud Carlos III; PI19/00335 Instituto de Salud Carlos III; SAF2017-84283-R Ministerio de Economía y Competitividad
- Contributed Indexing:
Keywords: Alzheimer’s disease; Biomarkers; Lipid nanoparticles; Metal nanoparticles; Nanotechnology; Polymeric nanoparticles
- الرقم المعرف:
0 (Amyloid beta-Peptides)
0 (Biomarkers)
- الموضوع:
Date Created: 20210430 Date Completed: 20211025 Latest Revision: 20231101
- الموضوع:
20240628
- الرقم المعرف:
PMC8086346
- الرقم المعرف:
10.1186/s12951-021-00864-x
- الرقم المعرف:
33926475
No Comments.