Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Disease Models, Animal*; Glaucoma/*pathology ; Ocular Hypertension/*physiopathology ; Retinal Degeneration/*pathology ; Retinal Ganglion Cells/*pathology ; Silicone Oils/*toxicity; Acute Disease ; Animals ; Female ; Glaucoma/chemically induced ; Intraocular Pressure ; Male ; Mice ; Mice, Inbred C57BL ; Ocular Hypertension/chemically induced ; Retinal Degeneration/chemically induced ; Retinal Ganglion Cells/drug effects ; Silicone Oils/administration & dosage

Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here we characterize two additional variations of this model that simulate two distinct glaucoma types. The first is a chronic model produced by high frequency (HF) pupillary dilation after SO-induced pupillary block, which shows sustained moderate IOP elevation and corresponding slow, mild glaucomatous neurodegeneration. We also demonstrate that although SO removal quickly returns IOP to normal, the glaucomatous neurodegeneration continues to advance to a similar degree as in the HF group without SO removal. The second, an acute model created by no pupillary dilation (ND), shows a greatly elevated IOP and severe inner retina degeneration at an early time point. Therefore, by a straightforward dilation scheme, we extend our original SOHU model to recapitulate phenotypes of two major glaucoma forms, which will be invaluable for selecting neuroprotectants and elucidating their molecular mechanisms.

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P30 EY026877 United States EY NEI NIH HHS; R01 EY023295 United States EY NEI NIH HHS; F32 EY029567 United States EY NEI NIH HHS; NIH F32 EY029567 United States NH NIH HHS; K08 EY022058 United States EY NEI NIH HHS; R01 EY024932 United States EY NEI NIH HHS; R21 EY031063 United States EY NEI NIH HHS; R01 EY025295 United States EY NEI NIH HHS; R01 EY028106 United States EY NEI NIH HHS

0 (Silicone Oils)

Date Created: 20210428 Date Completed: 20211014 Latest Revision: 20240402

20250114

PMC8079709

10.1038/s41598-021-88690-x

33907301