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Undiagnosed disease in decedents with and without schizophrenia: an autopsy-based case-control study.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 100927567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-4725 (Electronic) Linking ISSN: 08039488 NLM ISO Abbreviation: Nord J Psychiatry Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Oslo ; Boston : Scandinavian University Press, c1999-
    • الموضوع:
      Schizophrenia*/diagnosis ; Schizophrenia*/epidemiology ; Undiagnosed Diseases*; Autopsy ; Case-Control Studies ; Comorbidity ; Humans
    • نبذة مختصرة :
      Background: Individuals with schizophrenia (SCZ) suffer from higher morbidity and mortality than the general population. Some of this is due to concurrent somatic disease.
      Aims: To identify and compare the somatic comorbidities antemortem (AM) and postmortem (PM) in autopsied decedents with SCZ and with no mental illness (NMI), using the Charlson Comorbidity Index (CCI).
      Materials: A total of 106 autopsied decedents with SCZ and 156 decedents with NMI were included. AM diagnoses were sampled from Danish national health registers. PM diagnoses were included from forensic autopsies. Negative binomial regression models were used to test associations between age, sex, SCZ diagnosis, manner of death and the CCI score both AM and PM.
      Results: The CCI score increased significantly from AM to PM for both decedents with SCZ and NMI (SCZ, AM 0.669 vs PM 1.208, p  = 0.008) (NMI, AM 0.519 vs PM 1.218, p  = 0.000). Regression analysis showed that age was significantly associated with the CCI score both AM and PM (AM, OR 1.044 [1.029-1.060] p ≤ 0.001) (PM, OR 1.028 [1.015-1.041], p ≤ 0.001). A diagnosis of SCZ was correlated with the CCI score AM but not PM (AM, OR 1.880 [1.207-2.928], p  = 0.005) (PM, OR 1.170 [0.828-1.654], p  = 0.374).
      Conclusion: The autopsies revealed undiagnosed diseases in both decedents with SCZ and NMI. The diseases were primarily of cardiovascular, pulmonary and gastrointestinal origin and may have contributed to premature mortality. Age was the only covariate significantly associated with the CCI score both AM and PM; the SCZ diagnosis was positively correlated to the CCI score before death.
    • Contributed Indexing:
      Keywords: Charlson Comorbidity Index; Comorbidity; autopsy; schizophrenia
    • الموضوع:
      Date Created: 20210407 Date Completed: 20211119 Latest Revision: 20220428
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1080/08039488.2021.1905877
    • الرقم المعرف:
      33823753