Targeted memory reactivation in REM but not SWS selectively reduces arousal responses.

Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-

Arousal/*physiology ; Mental Recall/*physiology ; Sleep, REM/*physiology ; Sleep, Slow-Wave/*physiology; Adult ; Emotions ; Female ; Humans ; Memory ; Young Adult

A growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation.

Erratum in: Commun Biol. 2021 May 21;4(1):636. doi: 10.1038/s42003-021-02196-w. (PMID: 34021243)

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T32 HL110952 United States HL NHLBI NIH HHS; BB/J014478/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council

Date Created: 20210326 Date Completed: 20210806 Latest Revision: 20220329

20250114

PMC7994443

10.1038/s42003-021-01854-3

33767319