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Carob pod polyphenols suppress the differentiation of adipocytes through posttranscriptional regulation of C/EBPβ.
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- معلومة اضافية
- المصدر:
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- بيانات النشر:
Original Publication: San Francisco, CA : Public Library of Science
- الموضوع:
- نبذة مختصرة :
Obesity is a major risk factor for various chronic diseases such as diabetes, cardiovascular disease, and cancer; hence, there is an urgent need for an effective strategy to prevent this disorder. Currently, the anti-obesity effects of food ingredients are drawing attention. Therefore, we focused on carob, which has high antioxidant capacity and various physiological effects, and examined its anti-obesity effect. Carob is cultivated in the Mediterranean region, and its roasted powder is used as a substitute for cocoa powder. We investigated the effect of carob pod polyphenols (CPPs) on suppressing increases in adipose tissue weight and adipocyte hypertrophy in high fat diet-induced obesity model mice, and the mechanism by which CPPs inhibit the differentiation of 3T3-L1 preadipocytes into adipocytes in vitro. In an in vivo experimental system, we revealed that CPPs significantly suppressed the increase in adipose tissue weight and adipocyte hypertrophy. Moreover, in an in vitro experimental system, CPPs acted at the early stage of differentiation of 3T3-L1 preadipocytes and suppressed cell proliferation because of differentiation induction. They also suppressed the expression of transcription factors involved in adipocyte differentiation, thereby reducing triacylglycerol synthesis ability and triglycerol (TG) accumulation. Notably, CPPs regulated CCAAT/enhancer binding protein (C/EBP)β, which is expressed at the early stage of differentiation, at the posttranscriptional level. These results demonstrate that CPPs suppress the differentiation of adipocytes through the posttranscriptional regulation of C/EBPβ and may serve as an effective anti-obesity compound.
Competing Interests: A part of research grant and Carob pod polyphenols were provided by the TAISHO TECHNOS, Co., Ltd. We declare that these relationships did not affect the results and conclusions of this manuscript. This does not alter on adherence to PLOS ONE politics on sharing data and materials.
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- الرقم المعرف:
0 (CCAAT-Enhancer-Binding Protein-beta)
0 (Cebpb protein, mouse)
0 (Galactans)
0 (Mannans)
0 (Plant Gums)
0 (Polyphenols)
V4716MY704 (locust bean gum)
- الموضوع:
Date Created: 20210308 Date Completed: 20211012 Latest Revision: 20211012
- الموضوع:
20240628
- الرقم المعرف:
PMC7939365
- الرقم المعرف:
10.1371/journal.pone.0248073
- الرقم المعرف:
33684156
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