Attention-deficit/hyperactivity disorder and brain metabolites from proton magnetic resonance spectroscopy: a systematic review and meta-analysis protocol.

Publisher: Associação de Psiquiatria do Rio Grande do Sul Country of Publication: Brazil NLM ID: 101610695 Publication Model: Print Cited Medium: Internet ISSN: 2238-0019 (Electronic) Linking ISSN: 22376089 NLM ISO Abbreviation: Trends Psychiatry Psychother Subsets: MEDLINE

Original Publication: Porto Alegre, RS, Brasil : Associação de Psiquiatria do Rio Grande do Sul, [2011]-

Attention Deficit Disorder with Hyperactivity*/diagnostic imaging; Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Meta-Analysis as Topic ; Proton Magnetic Resonance Spectroscopy ; Systematic Reviews as Topic

Despite major advances in the study of the brain, investigations on neurochemistry in vivo still lack the solid ground of more established methods, such as structural and functional magnetic resonance imaging. Proton magnetic resonance spectroscopy (MRS) is a technique that might potentially fill in this gap. Nevertheless, studies using this approach feature great methodological heterogeneity, such as varying voxel of choice, differences on emphasized metabolites, and absence of a standardized unit. In this study, we present a methodology for creating a systematic review and meta-analysis for this kind of scientific evidence using the prototypical case of attention-deficit/hyperactivity disorder. Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO), CRD42018112418.

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Date Created: 20210308 Date Completed: 20211028 Latest Revision: 20240807

20240807

PMC7932040

10.47626/2237-6089-2019-0111

33681905