Signal amplification strategies for clinical biomarker quantification using elemental mass spectrometry.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE

Original Publication: Heidelberg : Springer-Verlag, 2002-

Biomarkers/*chemistry ; Mass Spectrometry/*methods ; Metal Nanoparticles/*chemistry; Hep G2 Cells ; Humans ; Sensitivity and Specificity

The current trends in modern medicine towards early diagnosis, or even prognosis, of different diseases have brought about the need for the corresponding biomarker detection at ever lower levels in really complex matrices. To do so, it is necessary to use proper extremely sensitive detection techniques such as elemental mass spectrometry. However, target labelling with metals for subsequent sensitive ICP-MS detection falls short nowadays even if resorting to inorganic nanoparticles containing a high number of detectable elements. Thus, new amplification strategies are being proposed to face this analytical challenge that will be critically discussed in this paper. Fundamentals of different novel strategies developed to achieve signal amplification and sensitive elemental mass spectrometry detection are here discussed. Some representative examples of relevant clinical applications are highlighted, along with future prospects and challenges.
(© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)

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PID2019- 109698GB-I00 Spanish Ministry of Economy and Competitiveness; FC-GRUPIN-IDI/2018/000166 Government of Principado de Asturias

Keywords: Biomarker quantification; Clinical biomarkers; Elemental mass spectrometry; Elemental tags; ICP-MS; Signal amplification

0 (Biomarkers)

Date Created: 20210306 Date Completed: 20220317 Latest Revision: 20220317

20240628

10.1007/s00216-021-03251-5

33674934