Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Severe primary hypothyroidism in an apparently asymptomatic 19-year-old woman: a case report.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Dannan R;Dannan R; Hajji S; Hajji S; Aljenaee K; Aljenaee K
  • المصدر:
    Journal of medical case reports [J Med Case Rep] 2021 Mar 03; Vol. 15 (1), pp. 108. Date of Electronic Publication: 2021 Mar 03.
  • نوع النشر :
    Case Reports; Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101293382 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-1947 (Electronic) Linking ISSN: 17521947 NLM ISO Abbreviation: J Med Case Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, [2007-
    • الموضوع:
      Hypothyroidism/*diagnosis ; Thyroiditis, Autoimmune/*diagnosis; Alopecia/physiopathology ; Appetite ; Autoantibodies/immunology ; Constipation/physiopathology ; Depression/physiopathology ; Fatigue/physiopathology ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/drug therapy ; Hypothyroidism/physiopathology ; Incidental Findings ; Iodide Peroxidase/immunology ; Menorrhagia/physiopathology ; Severity of Illness Index ; Thyroid Gland/diagnostic imaging ; Thyroiditis, Autoimmune/blood ; Thyroiditis, Autoimmune/immunology ; Thyroiditis, Autoimmune/physiopathology ; Thyrotropin/blood ; Thyroxine/blood ; Thyroxine/therapeutic use ; Ultrasonography ; Weight Gain ; Young Adult
    • نبذة مختصرة :
      Background: Hypothyroidism is diagnosed on the basis of laboratory tests because of the lack of specificity of the typical clinical manifestations. There is conflicting evidence on screening for hypothyroidism.
      Case Presentation: We report a case of an apparently healthy 19-year-old Kuwaiti woman referred to our clinic with an incidental finding of extremely high thyroid-stimulating hormone (TSH), tested at the patient's insistence as she had a strong family history of hypothyroidism. Despite no stated complaints, the patient presented typical symptoms and signs of hypothyroidism on evaluation. Thyroid function testing was repeated by using different assays, with similar results; ultrasound imaging of the thyroid showed a typical picture of thyroiditis. Treatment with levothyroxine alleviated symptoms and the patient later became biochemically euthyroid on treatment.
      Conclusion: There is controversy regarding screening asymptomatic individuals for hypothyroidism; therefore, it is important to maintain a high index of suspicion when presented with mild signs and symptoms of hypothyroidism especially with certain ethnic groups, as they may be free of the classical symptoms of disease.
    • References:
      Ann Saudi Med. 1995 Mar;15(2):143-7. (PMID: 17587925)
      Am J Med. 2016 Oct;129(10):1082-92. (PMID: 27393881)
      Med J Aust. 1972 Oct 28;2(18):981-6. (PMID: 4198601)
      Thyroid. 2012 Dec;22(12):1200-35. (PMID: 22954017)
      BMJ. 1996 Aug 31;313(7056):539-44. (PMID: 8789985)
      J Family Community Med. 2003 Jan;10(1):55-8. (PMID: 23011981)
      Ann Intern Med. 2015 May 5;162(9):641-50. (PMID: 25798805)
      Nat Rev Endocrinol. 2018 May;14(5):301-316. (PMID: 29569622)
    • Contributed Indexing:
      Keywords: Asymptomatic; Case report; Hypothyroidism; Screening; TSH
    • الرقم المعرف:
      0 (Autoantibodies)
      9002-71-5 (Thyrotropin)
      EC 1.11.1.8 (Iodide Peroxidase)
      Q51BO43MG4 (Thyroxine)
    • الموضوع:
      Date Created: 20210303 Date Completed: 20210315 Latest Revision: 20210315
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC7927371
    • الرقم المعرف:
      10.1186/s13256-021-02677-w
    • الرقم المعرف:
      33653380