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Effects of constant light exposure on allergic and irritant contact dermatitis in mice reared under constant light conditions.

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  • معلومة اضافية
    • المصدر:
      Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Copenhagen : Munksgaard, c1992-
    • الموضوع:
    • نبذة مختصرة :
      Environmental light levels can affect physiological functions, such as general activity, body temperature and metabolism. Irregular lifestyles, such as those involving exposure to light during the night, can exacerbate the clinical symptoms of several inflammatory skin diseases. However, the effects of constant light exposure on immune responses are not fully understood. This study aimed to elucidate the effects of constant light exposure on two major types of skin reactions, allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). BALB/c mice were kept under constant light conditions or a normal light and dark cycle, and their ACD and ICD responses were assessed after the topical application of 2,4,6-trinitro-1-chlorobenzene and croton oil, respectively, to the ear skin. Interestingly, in both ACD and ICD, the ear-swelling response and local leukocyte infiltration were aggravated by constant exposure to light, which has previously been shown to severely disturb the behavioural rhythms of mice. In ACD, these findings were accompanied by increases in the numbers of degranulated mast cells and eosinophils. These results suggest that constant light exposure intensifies allergic and non-allergic skin inflammation.
      (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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    • Contributed Indexing:
      Keywords: allergic contact dermatitis; constant light; eosinophils; irritant contact dermatitis; mast cells
    • الرقم المعرف:
      0 (Allergens)
      0 (Irritants)
    • الموضوع:
      Date Created: 20210225 Date Completed: 20220323 Latest Revision: 20220323
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/exd.14308
    • الرقم المعرف:
      33629775