Efficacy of grape seed hydro-alcoholic extract in the treatment of experimentally Pasteurella multocida infected rabbits.

Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101678837 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2053-1095 (Electronic) Linking ISSN: 20531095 NLM ISO Abbreviation: Vet Med Sci Subsets: MEDLINE

Original Publication: [Oxford] : John Wiley & Sons Ltd., [2015]-

Anti-Bacterial Agents/*pharmacology ; Grape Seed Extract/*pharmacology ; Pasteurella Infections/*veterinary ; Pasteurella multocida/*drug effects ; Vitis/*chemistry; Animals ; Male ; Pasteurella Infections/drug therapy ; Pasteurella Infections/microbiology ; Rabbits

Pasteurellosis is one of the rabbit's most bacterial severe diseases and leads to considerable financial damages in large production systems worldwide. Antibiotic use in animals may lead to antibiotic residues in animal products, including meat. Therefore, this study was designed to evaluate the potential role of grape seed extract (GSE) in treating Pasteurella multocida infection in rabbits. For this purpose, 45 weaned male New Zealand rabbits were divided into three groups; control, infected and infected-GSE treated. Experimental P. multocida infection in rabbits induced a remarkable decrease in body weight, body weight gain, as well as microcytic hypochromic anaemia, leucocytosis, neutrophilia and lymphocytopenia. Also, a significant increase in the hepatic and renal injury biomarkers, in interleukin-6, total globulin, α, β and γ globulins, as well as a marked reduction in total protein and albumin, were recorded in the P. multocida-infected rabbits. Treatment of infected rabbits with GSE modulated most of these altered parameters. This study endorses the administration of GSE for the treatment of Pasteurellosis in rabbits. Further studies are required to identify the possible additional effects, appropriate doses and duration of the GSE therapy in rabbits Pasteurellosis.
(© 2021 The Authors Veterinary Medicine and Science Published by John Wiley & Sons Ltd.)

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Keywords: Pasteurella multocida; GC-MS; grape seed extract; rabbit

0 (Anti-Bacterial Agents)
0 (Grape Seed Extract)

Date Created: 20210216 Date Completed: 20211019 Latest Revision: 20211019

20221213

PMC8136928

10.1002/vms3.446

33590677