Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series.

Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE

Original Publication: [London] : BioMed Central, c2008-

Anovulation/*physiopathology ; Follicle Stimulating Hormone, Human/*therapeutic use ; Hyperandrogenism/*physiopathology ; Infertility, Female/*therapy ; Ovarian Hyperstimulation Syndrome/*epidemiology ; Ovulation Induction/*methods ; Polycystic Ovary Syndrome/*physiopathology; Adult ; Aromatase Inhibitors/therapeutic use ; Chorionic Gonadotropin/therapeutic use ; Dopamine Agonists/therapeutic use ; Female ; Fertilization in Vitro ; Gonadotropin-Releasing Hormone/agonists ; Humans ; Infertility, Female/complications ; Oocyte Retrieval ; Ovarian Hyperstimulation Syndrome/chemically induced ; Ovarian Hyperstimulation Syndrome/prevention & control ; Phenotype ; Polycystic Ovary Syndrome/complications ; Pregnancy ; Pregnancy Rate ; Recombinant Proteins/therapeutic use ; Reproductive Control Agents/therapeutic use ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Tissue Preservation

Background: To explore the efficacy of follitropin delta in ovarian stimulation of patients with the Rotterdam ESHRE/ASRM 2003 phenotypes of polycystic ovarian syndrome (PCOS) using a retrospective case series with an electronic file search in a reproductive medicine clinic.
Case Presentation: Seventy-four patients with PCOS undergoing ovarian stimulation according to the individualized dosing algorithm of follitropin delta for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI)/oocyte freezing were included. Follitropin delta resulted in a high number of pre-ovulatory follicles at the end of stimulation as expected in patients with PCOS. There was a large number of oocytes retrieved with an acceptable percentage of metaphase II (MII) oocytes. There were no cases of moderate or severe OHSS across all phenotypes.
Conclusion: Follitropin delta, using the individualized dosing algorithm, appears to be a safe method of ovarian stimulation with a low risk of OHSS in PCOS patients without sacrificing successful stimulation outcomes.

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Keywords: Follitropin delta; OHSS; Polycystic ovary syndrome; Recombinant FSH; Rotterdam criteria

0 (Aromatase Inhibitors)
0 (Chorionic Gonadotropin)
0 (Dopamine Agonists)
0 (Follicle Stimulating Hormone, Human)
0 (Recombinant Proteins)
0 (Reproductive Control Agents)
076WHW89TW (follitropin delta)
33515-09-2 (Gonadotropin-Releasing Hormone)

Date Created: 20210213 Date Completed: 20210902 Latest Revision: 20210902

20231215

PMC7881448

10.1186/s13048-021-00773-5

33579321