Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- معلومة اضافية
- المصدر:
Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI Publishing
- الموضوع:
- نبذة مختصرة :
Globally, more than one-third of adults are overweight. Overweight and obesity are complex and multifaceted conditions, associated with an increased risk of chronic illness and early mortality. While there are known risk factors, these alone do not fully explain the varying outcomes between individuals. Recently, taste receptors have been proposed to have a role in the risk for obesity. These receptors are expressed throughout the gastrointestinal tract. In this system, they may be involved in modulating dietary intake and metabolic processes. The taste 2 family of receptors (T2Rs) detects bitter compounds. Receptors T2R4 and T2R5 detect (-)-epicatechin (epicatechin), an antioxidant polyphenol, which may have protective effects against obesity. However, the potential role for taste receptors in this association has not been explored. This study assessed whether polymorphisms in TAS2R4 (rs2233998 and rs2234001) and TAS2R5 (rs2227264) were associated with body mass index (BMI). Genotyping (Taqman qPCR assays) was performed on DNA extracted from blood samples ( n = 563) from an elderly cohort. Homozygosity for the minor allele of all polymorphisms was significantly associated with a lower BMI in males. The TAS2R4 -rs2233998 CC genotype, the TAS2R4 -rs2234001 CC genotype and the TAS2R5 -rs2227264 TT genotype were associated with lower BMI (2.1, 2.1 and 2.2 units; p = 0.002, 0.003 and 0.001, respectively). Epicatechin intake was not associated with BMI and genotype was not associated with epicatechin intake. This suggests that the association between TAS2R genotype and elevated BMI risk occurs through altered extra-oral responses and not directly via altered epicatechin intake.
- References:
N Engl J Med. 2011 Apr 7;364(14):1315-25. (PMID: 21470009)
Postgrad Med J. 2006 Apr;82(966):239-41. (PMID: 16597809)
Appetite. 2017 Sep 1;116:57-64. (PMID: 28455260)
Anim Genet. 2018 Apr;49(2):110-118. (PMID: 29441627)
Eur J Gastroenterol Hepatol. 2005 Sep;17(9):961-5. (PMID: 16093874)
Science. 2003 Feb 21;299(5610):1221-5. (PMID: 12595690)
J Health Care Poor Underserved. 2011;22(4 Suppl):61-72. (PMID: 22102306)
Front Genet. 2019 Dec 19;10:1272. (PMID: 31921309)
Am J Clin Nutr. 2018 Jun 1;107(6):948-956. (PMID: 29868915)
Epidemiol Health. 2014 Jul 22;36:e2014009. (PMID: 25078382)
J Agric Food Chem. 2013 Feb 20;61(7):1525-33. (PMID: 23311874)
Am J Physiol Cell Physiol. 2006 Oct;291(4):C726-39. (PMID: 16707556)
Database (Oxford). 2010;2010:bap024. (PMID: 20428313)
Chem Senses. 2011 Mar;36(3):311-9. (PMID: 21163912)
Metabolism. 2019 Mar;92:6-10. (PMID: 30253139)
Appetite. 2010 Feb;54(1):93-9. (PMID: 19782709)
Obesity (Silver Spring). 2008 Jul;16(7):1522-8. (PMID: 18421272)
Appetite. 2016 Dec 1;107:126-134. (PMID: 27475756)
Appetite. 2017 Jun 1;113:178-186. (PMID: 28232057)
Annu Rev Nutr. 2016 Jul 17;36:157-82. (PMID: 27070900)
Ann Nutr Metab. 2011;58(3):250-8. (PMID: 21829010)
Mol Aspects Med. 2018 Jun;61:2-11. (PMID: 29146101)
Sci Rep. 2015 Nov 06;5:15985. (PMID: 26541810)
Food Funct. 2017 Mar 22;8(3):1116-1123. (PMID: 28164195)
N Engl J Med. 2017 Jul 6;377(1):13-27. (PMID: 28604169)
J Dev Orig Health Dis. 2020 Feb;11(1):37-43. (PMID: 31179955)
Nutrients. 2019 Jun 06;11(6):. (PMID: 31174347)
Am J Clin Nutr. 2010 Jan;91(1):73-81. (PMID: 19906797)
Nutrients. 2019 Aug 21;11(9):. (PMID: 31438650)
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2094-9. (PMID: 21245306)
Nutrients. 2018 Sep 20;10(10):. (PMID: 30241292)
Mol Nutr Food Res. 2016 Jul;60(7):1673-83. (PMID: 27059147)
N Engl J Med. 2006 Aug 24;355(8):763-78. (PMID: 16926275)
Chem Senses. 2008 Mar;33(3):255-65. (PMID: 18209019)
Physiol Behav. 2007 Apr 23;90(5):809-17. (PMID: 17313965)
Gut. 2014 Jan;63(1):179-90. (PMID: 24131638)
Food Chem. 2018 Feb 15;241:480-492. (PMID: 28958556)
Obesity (Silver Spring). 2008 Oct;16(10):2289-95. (PMID: 18719631)
Chem Senses. 2010 Feb;35(2):157-70. (PMID: 20022913)
Lancet Diabetes Endocrinol. 2018 Mar;6(3):223-236. (PMID: 28919064)
Obesity (Silver Spring). 2010 Jun;18(6):1194-200. (PMID: 19779476)
Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3684-3689. (PMID: 27129026)
J Hum Nutr Diet. 2009 Dec;22(6):559-66. (PMID: 19735348)
J Nutr Biochem. 2016 Jan;27:233-40. (PMID: 26475216)
PLoS Genet. 2015 Sep 25;11(9):e1005530. (PMID: 26406243)
PLoS One. 2008;3(12):e3974. (PMID: 19092995)
Sci Rep. 2018 Oct 9;8(1):15004. (PMID: 30301923)
J Clin Invest. 2008 Nov;118(11):3693-700. (PMID: 18846256)
Nutrients. 2020 Apr 10;12(4):. (PMID: 32290310)
Eur J Clin Nutr. 2006 Jun;60(6):698-705. (PMID: 16435003)
Food Funct. 2014 Mar;5(3):521-7. (PMID: 24458104)
Int J Food Sci Nutr. 2018 Mar;69(2):245-252. (PMID: 28738701)
JAMA Intern Med. 2014 Jan;174(1):98-106. (PMID: 24217806)
Lancet Public Health. 2017 May 19;2(6):e277-e285. (PMID: 28626830)
Am J Clin Nutr. 2016 Sep;104(3):613-9. (PMID: 27510533)
Genetics. 2005 May;170(1):313-26. (PMID: 15744053)
Diabetes Care. 2009 Nov;32 Suppl 2:S398-402. (PMID: 19875588)
Physiol Behav. 2002 Mar;75(3):305-12. (PMID: 11897256)
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1024-9. (PMID: 16418281)
Ann N Y Acad Sci. 2009 Jul;1170:126-39. (PMID: 19686122)
Obes Res. 2004 Jun;12(6):904-12. (PMID: 15229328)
Mol Biol Evol. 2003 May;20(5):805-14. (PMID: 12679530)
J Acad Nutr Diet. 2015 Mar;115(3):389-96. (PMID: 25441957)
Appetite. 2004 Aug;43(1):5-9. (PMID: 15262011)
- Contributed Indexing:
Keywords: BMI; bitter; epicatechin; obesity; phenol; taste genetics; taste receptors
- الرقم المعرف:
0 (Receptors, G-Protein-Coupled)
0 (TAS2R4 protein, human)
0 (taste receptors, type 2)
8R1V1STN48 (Catechin)
- الموضوع:
Date Created: 20210212 Date Completed: 20210902 Latest Revision: 20210902
- الموضوع:
20240628
- الرقم المعرف:
PMC7914776
- الرقم المعرف:
10.3390/nu13020571
- الرقم المعرف:
33572225
No Comments.