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Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer.
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- معلومة اضافية
- المصدر:
Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI Publishing
- الموضوع:
- نبذة مختصرة :
The seeds of Euphorbia lathyris have been used in traditional medicine to treat various medical conditions. However, neither all of their active biocompounds nor the molecular mechanisms underlying their therapeutic effects have been described. A new ethanolic extract of defatted flour from mature seeds of Euphorbia lathyris showed a high total polyphenol content and significant antioxidant activity. Chromatographic analysis showed that esculetin, euphorbetin, gaultherin, and kaempferol-3-rutinoside were the most abundant polyphenolic bioactive compounds. Antiproliferative assays showed a high and selective antitumor activity against colon cancer cell lines (T84 and HCT-15). In addition, a significant antiproliferative activity against glioblastoma multiforme cells was also demonstrated. Its mechanism of action to induce cell death was mediated by the overexpression of caspases 9, 3, and 8, and by activation of autophagy. Interestingly, a reduction in the migration capacity of colon cancer cells and a significant antiangiogenic effect on human umbilical vein endothelial cells were also demonstrated. Finally, the extract significantly reduced the subpopulations of cancer stem cells. This extract could be the basis to develop new therapeutic strategies for the treatment of colon cancer, although further experiments will be necessary to determine its in vivo effects.
- References:
Cancer Lett. 2002 Sep 26;183(2):163-8. (PMID: 12065091)
Mol Cancer. 2016 Oct 18;15(1):64. (PMID: 27756327)
Cancer Lett. 2021 Jan 28;497:190-201. (PMID: 33039561)
Cancer Med. 2019 Mar;8(3):882-889. (PMID: 30690930)
Adv Exp Med Biol. 2019;1139:115-126. (PMID: 31134498)
J BUON. 2019 Jul-Aug;24(4):1686-1691. (PMID: 31646826)
J Sci Food Agric. 2015 Apr;95(6):1207-16. (PMID: 25043425)
Nat Rev Dis Primers. 2015 Nov 05;1:15065. (PMID: 27189416)
Molecules. 2019 Jun 25;24(12):. (PMID: 31242603)
World J Gastroenterol. 2016 Apr 7;22(13):3564-72. (PMID: 27053848)
Phytochem Anal. 2019 Sep;30(5):498-511. (PMID: 31218764)
Exp Ther Med. 2018 Aug;16(2):557-566. (PMID: 30112023)
Planta Med. 2018 Jul;84(9-10):558-567. (PMID: 29169187)
J Invest Dermatol. 2017 Feb;137(2):e11-e16. (PMID: 28110712)
Phytochemistry. 2014 Aug;104:79-88. (PMID: 24856111)
Phytochem Anal. 2001 Jul-Aug;12(4):255-62. (PMID: 11705332)
Iran J Pharm Res. 2012 Winter;11(1):241-9. (PMID: 24250446)
Chem Biodivers. 2018 Nov;15(11):e1800386. (PMID: 30156375)
J Nat Prod. 2016 Jan 22;79(1):126-31. (PMID: 26702644)
J Nat Prod. 2014 Apr 25;77(4):792-9. (PMID: 24660966)
Oncol Rep. 2011 Jan;25(1):223-30. (PMID: 21109980)
Tumour Biol. 2016 Apr;37(4):4665-78. (PMID: 26508031)
J Ethnopharmacol. 2015 Dec 24;176:90-101. (PMID: 26485050)
CA Cancer J Clin. 2018 Jan;68(1):7-30. (PMID: 29313949)
Oncotarget. 2017 Dec 22;9(70):33403-33415. (PMID: 30279970)
J Ethnopharmacol. 2016 Dec 24;194:1-5. (PMID: 27566201)
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 Apr 1;35(2):244-251. (PMID: 29745530)
Phytomedicine. 2018 Aug 1;47:105-112. (PMID: 30166094)
Curr Top Med Chem. 2017;17(2):96-106. (PMID: 27237328)
Environ Toxicol. 2019 Oct;34(10):1129-1136. (PMID: 31313495)
Phytochemistry. 2020 Nov;179:112504. (PMID: 32980713)
J Ethnopharmacol. 2020 Jun 12;255:112722. (PMID: 32114165)
Org Lett. 2005 Mar 31;7(7):1379-82. (PMID: 15787511)
Environ Toxicol Pharmacol. 2015 Mar;39(2):982-9. (PMID: 25818986)
Sci Rep. 2016 Jul 28;6:30531. (PMID: 27464466)
Chem Rev. 2008 Oct;108(10):4295-327. (PMID: 18817355)
Lancet. 2018 Sep 22;392(10152):985. (PMID: 30264708)
Phytomedicine. 2019 Sep;62:152931. (PMID: 31085375)
Chem Rev. 2014 Sep 10;114(17):8579-612. (PMID: 25036812)
Am J Chin Med. 2016;44(1):61-76. (PMID: 26916914)
EPMA J. 2020 May 29;11(2):261-287. (PMID: 32547652)
Molecules. 2017 Aug 18;22(8):. (PMID: 28820480)
J Mol Med (Berl). 2009 Sep;87(9):899-911. (PMID: 19579018)
J Nat Prod. 2016 Aug 26;79(8):1952-61. (PMID: 27447736)
Biomed Res Int. 2020 Jan 14;2020:3618941. (PMID: 32420336)
Phytomedicine. 2018 Mar 1;41:62-66. (PMID: 29519320)
J Ethnopharmacol. 2021 Jan 30;265:113348. (PMID: 32896626)
Life Sci. 2020 Oct 15;259:118255. (PMID: 32818543)
Afr J Tradit Complement Altern Med. 2017 Mar 01;14(3):105-112. (PMID: 28480421)
J Cancer Prev. 2018 Mar;23(1):10-17. (PMID: 29629344)
J Asian Nat Prod Res. 2020 May 22;:1-7. (PMID: 32441128)
J Ethnopharmacol. 2018 Dec 5;227:41-55. (PMID: 30144497)
- Grant Information:
PSE/17/002 Universidad de Granada; RTC-2017-6540-1 Ministerio de Ciencia e Innovación
- Contributed Indexing:
Keywords: Euphorbia lathyris; antiangiogenic effect; apoptosis; cancer stem cells; colon cancer; ethanolic extract
- الرقم المعرف:
0 (Antineoplastic Agents, Phytogenic)
0 (Antioxidants)
0 (Plant Extracts)
0 (Polyphenols)
3K9958V90M (Ethanol)
- الموضوع:
Date Created: 20210212 Date Completed: 20210902 Latest Revision: 20210902
- الموضوع:
20240628
- الرقم المعرف:
PMC7915714
- الرقم المعرف:
10.3390/nu13020566
- الرقم المعرف:
33572111
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