Rapid Spread and Control of Multidrug-Resistant Gram-Negative Bacteria in COVID-19 Patient Care Units.

Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-

Anti-Bacterial Agents*/classification ; Anti-Bacterial Agents*/therapeutic use ; COVID-19*/epidemiology ; COVID-19*/physiopathology ; COVID-19*/therapy ; Critical Illness*/epidemiology ; Critical Illness*/therapy ; Gram-Negative Bacteria*/classification ; Gram-Negative Bacteria*/drug effects ; Gram-Negative Bacteria*/isolation & purification ; Infection Control*/methods ; Infection Control*/organization & administration ; Practice Patterns, Nurses'*/organization & administration ; Practice Patterns, Nurses'*/standards ; Superinfection*/diagnosis ; Superinfection*/microbiology; Drug Resistance, Multiple, Bacterial ; Humans ; Intensive Care Units/organization & administration ; Maryland/epidemiology ; Microbiological Techniques/methods ; Microbiological Techniques/statistics & numerical data ; Precipitating Factors ; Risk Factors ; SARS-CoV-2

We describe rapid spread of multidrug-resistant gram-negative bacteria among patients in dedicated coronavirus disease care units in a hospital in Maryland, USA, during May-June 2020. Critical illness, high antibiotic use, double occupancy of single rooms, and modified infection prevention practices were key contributing factors. Surveillance culturing aided in outbreak recognition and control.

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Keywords: COVID-19; MDR; Maryland; SARS-CoV-2; United States; antimicrobial resistance; bacteria; bacterial infections; coronavirus disease; gram-negative; multidrug resistant; outbreak; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses

0 (Anti-Bacterial Agents)

Date Created: 20210210 Date Completed: 20210401 Latest Revision: 20210406

20231215

PMC8007317

10.3201/eid2704.204036

33565961