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Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network.

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  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2015- : Philadelphia, PA : Taylor & Francis
      Original Publication: Austin, Tex. : Landes Bioscience
    • الموضوع:
      Host Microbial Interactions/*drug effects ; Plasma Gases/*pharmacology ; Virus Replication/*drug effects; Animals ; Autophagy/drug effects ; Cattle ; Cell Cycle/drug effects ; Cell Line ; Host Microbial Interactions/immunology ; Kidney/cytology ; Virus Replication/immunology
    • نبذة مختصرة :
      Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bovine rhinotrachieitis virus and Madin-Darby Bovine Kidney cells were used as the modeling virus and cell line, respectively. CAP was shown to create synergies with virus infection in arresting host cells at the G2/M stage, decreasing cell membrane potential, increasing intracellular calcium level, and inducing selective autophagy. In addition, CAP was demonstrated to suppress virus-triggered immunogenic signaling as evaluated by IRF7 expression. We presented evidences on CAP-triggered maximization of host resources toward virus multiplication that is advantageous for viral vaccine production, and opened a novel regime for applying CAP in the sector of medical care and health.
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    • Contributed Indexing:
      Keywords: Cold atmospheric plasma; IBRV; MDBK; host-virus interaction
    • الرقم المعرف:
      0 (Plasma Gases)
    • الموضوع:
      Date Created: 20210208 Date Completed: 20210930 Latest Revision: 20210930
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC7889027
    • الرقم المعرف:
      10.1080/21505594.2021.1883933
    • الرقم المعرف:
      33554733