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Exploring determinants of psoriasis patients' treatment choices: a discrete-choice experiment study in the United States and Germany.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Houndmills, Basingstoke, Hampshire, UK : M. Dunitz and Macmillan Press, [c1989]-
    • الموضوع:
      Biological Products*/therapeutic use ; Psoriasis*/drug therapy; Germany ; Humans ; Patient Preference ; Surveys and Questionnaires ; United States
    • نبذة مختصرة :
      Background: Biologic psoriasis treatments are differentiated by efficacy, side effects, and other attributes.
      Objective: Determine attributes of biologic psoriasis treatments that drive patients' treatment choices.
      Methods: Respondents (USA: n  = 300; Germany: n  = 300) with moderate-to-severe psoriasis completed a discrete-choice-experiment survey, choosing between hypothetical treatments characterized by attributes with varying levels: chance of clear skin after 1 year, number of first-year treatments, first-year risks of mild-to-moderate injection site reaction (ISR) and serious infection, and years of proven efficacy/safety.
      Results: U.S. respondents most valued clear skin (conditional relative importance, 1.88; p  < .05). While other attributes were of generally equivalent importance, ISR risk outweighed serious-infection risk (1.06 vs. 0.70; p  < .05). German respondents placed greatest importance on ISR risk (1.61; p  < .05) and clear skin (1.49; p  < .05).
      Limitations: Respondents evaluated hypothetical treatments and were recruited from web panels.
      Conclusions: Clear skin and ISR risk are stronger drivers of treatment choice than injection frequency and infection risk.
    • Contributed Indexing:
      Keywords: Psoriasis; discrete-choice experiment; patient; preference
    • الرقم المعرف:
      0 (Biological Products)
    • الموضوع:
      Date Created: 20210204 Date Completed: 20220609 Latest Revision: 20220609
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1080/09546634.2020.1839007
    • الرقم المعرف:
      33535847