Detection of antibodies to duck tembusu virus in human population with or without the history of contact with ducks.

Publisher: Blackwell Verlag Country of Publication: Germany NLM ID: 101319538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-1682 (Electronic) Linking ISSN: 18651674 NLM ISO Abbreviation: Transbound Emerg Dis Subsets: MEDLINE

Original Publication: Berlin : Blackwell Verlag

Flavivirus* ; Flavivirus Infections*/epidemiology ; Flavivirus Infections*/veterinary ; Poultry Diseases*; Animals ; Ducks ; Humans ; Thailand/epidemiology

Duck tembusu virus (DTMUV) is an emerging duck pathogen in China and other Asian countries. It is unclear whether this emerging zoonotic infection poses a threat to humans. A previous study in 2012 showed surprisingly high rates of seropositivity and positive viral detection by RT-PCR in duck farm workers in China. To understand the nature of the threat of this emerging virus, we studied the neutralizing antibody response to a local isolate of DTMUV in an at-risk population, who were workers in duck farms and residents around farming areas in Central Thailand where DTMUV had been previously detected, and in a not-at-risk population, who were people living in the same or neighbouring province, but at a distance from the farms and who had no contact with ducks. The sera from the at-risk population showed higher anti-DTMUV neutralizing antibody titres as compared with those of the not-at-risk population. However, within the at-risk population, workers with direct contact with ducks did not show higher neutralizing titres than those without direct contact. Interestingly, some people in the not-at-risk group also displayed high neutralizing antibody titres to DTMUV. These sera were tested against other endemic Flaviviruses and showed no or low cross-reactivity suggesting the specificity of the neutralizing activity against DTMUV. These data raise a possibility of DTMUV as a potential zoonotic pathogen but the mode of transmission of the virus from ducks or other possible hosts to humans should be explored further.
(© 2021 Wiley-VCH GmbH.)

Cao, Z., Zhang, C., Liu, Y., Ye, W., Han, J., Ma, G., … Zhang, D. (2011). Tembusu virus in ducks, China. Emerging Infectious Diseases, 17(10), 1873-1875. https://doi.org/10.3201/eid1710.101890.
Chakritbudsabong, W., Taowan, J., Lertwatcharasarakul, P., Phattanakunanan, S., Munkhong, A., Songserm, T., & Chaichoun, K. (2015). Genomic characterization of a new tembusu flavivirus from domestic ducks in Thailand. Thai Journal of Veterinary Medicine, 45(3), 419-425.
Henchal, E., Gentry, M., McCown, J., & Brandt, W. (1982). Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence. American Journal of Tropical Medicine and Hygiene, 31(4), 830-836. https://doi.org/10.4269/ajtmh.1982.31.830.
Li, S., Li, X., Zhang, L., Wang, Y., Yu, X., Tian, K., Su, W., Han, B. O., … Su, J. (2013). Duck tembusu virus exhibits neurovirulence in BALB/c mice. Virology Journal, 10, 260. https://doi.org/10.1186/1743-422X-10-260.
Li, X., Shi, Y., Liu, Q., Wang, Y., Li, G., Teng, Q., … Li, Z. (2015). Airborne transmission of a novel tembusu virus in ducks. Journal of Clinical Microbiology, 53(8), 2734-2736. https://doi.org/10.1128/JCM.00770-15.
Ninvilai, P., Nonthabenjawan, N., Limcharoen, B., Tunterak, W., Oraveerakul, K., Banlunara, W., … Thontiravong, A. (2018). The presence of duck tembusu virus in Thailand since 2007: A retrospective study. Transboundary and Emerging Diseases, 65(5), 1208-1216. https://doi.org/10.1111/tbed.12859.
Ninvilai, P., Tunterak, W., Oraveerakul, K., Amonsin, A., & Thontiravong, A. (2019). Genetic characterization of duck tembusu virus in Thailand, 2015-2017: Identification of a novel cluster. Transboundary and Emerging Diseases, 66(5), 1982-1992. https://doi.org/10.1111/tbed.13230.
Pandey, B. D., Karabatsos, N., Cropp, B., Tagaki, M., Tsuda, Y., Ichinose, A., & Igarashi, A. (1999). Identification of a flavivirus isolated from mosquitoes in Chiang Mai Thailand. Southeast Asian Journal of Tropical Medicine and Public Health, 30(1), 161-165.
Platt, G. S., Way, H. J., Bowen, E. T. W., Simpson, D. I. H., Hill, M. N., Kamath, S., … Heathcote, O. H. U. (1975). Arbovirus infections in Sarawak, October 1968-February 1970 Tembusu and Sindbis virus isolations from mosquitoes. Annals of Tropical Medicine and Parasitology, 69(1), 65-71. https://doi.org/10.1080/00034983.1975.11686984.
Su, J., Li, S., Hu, X., Yu, X., Wang, Y., Liu, P., … Gao, G. F. (2011). Duck egg-drop syndrome caused by BYD virus, a new Tembusu-related flavivirus. PLoS One, 6(3), e18106. https://doi.org/10.1371/journal.pone.0018106.
Tang, Y., Diao, Y., Chen, H., Ou, Q., Lui, X., Gao, X., … Wang, L. (2013). Isolation and genetic characterization of Tembusu virus isolated from mosquitoes in Shandong. China. Transboundary and Emerging Diseases, 60(2), 209-216.
Tang, Y., Diao, Y., Yu, C., Gao, X., Ju, X., Xue, C., Lui, X., … Zhang, D. (2013). Characterization of Tembusu virus isolated from naturally infected house sparrows (Passer domesticus) in Northern China. Transboundary and Emerging Diseases, 60(2), 152-158.
Tang, Y., Gao, X., Diao, Y., Feng, Q., Chen, H., Liu, X., Ge, P., … Yu, C. (2013). Tembusu virus in human, China. Transboundary and Emerging Diseases, 60(3), 193-196. https://doi.org/10.1111/tbed.12085.
Thontiravong, A., Ninvilai, P., Tunterak, W., Nonthabenjawan, N., Chaiyavong, S., Angkabkingkaew, K., … Amonsin, A. (2015). Tembusu-related flavivirus in ducks, Thailand. Emerging Infectious Diseases, 21(12), 2164-2167. https://doi.org/10.3201/eid2112.150600.
Ti, J., Zhang, M., Li, Z., Li, X., & Diao, Y. (2016). Duck tembusu virus exhibits pathogenicity to kunming mice by intracerebral inoculation. Frontiers in Microbiology, 7, 190. https://doi.org/10.3389/fmicb.2016.00190.
Wang, H.-J., Li, X.-F., Liu, L., Xu, Y.-P., Ye, Q., Deng, Y.-Q., … Qin, C.-F. (2016). The emerging duck flavivirus is not pathogenic for primates and is highly sensitive to mammalian interferon antiviral signaling. Journal of Virology, 90(14), 6538-6548. https://doi.org/10.1128/JVI.00197-16.
Yu, G., Lin, Y., Tang, Y., & Diao, Y. (2018). Evolution of tembusu virus in ducks, chickens, geese, sparrows, and mosquitoes in Northern China. Viruses, 10(9), 485. https://doi.org/10.3390/v10090485.
Zhang, Y., Li, X., Chen, H., Ti, J., Yang, G., Zhang, L. U., … Diao, Y. (2015). Evidence of possible vertical transmission of Tembusu virus in ducks. Veterinary Microbiology, 179(3-4), 149-154. https://doi.org/10.1016/j.vetmic.2015.06.004.

IRN60W0002 Thailand Research Fund

Keywords: Serological surveillance; Thai duck farm workers; Thai population; duck tembusu virus

Tembusu virus

Date Created: 20210120 Date Completed: 20220331 Latest Revision: 20220401

20231215

10.1111/tbed.13998

33470024