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Bisphenol A at a human exposed level can promote epithelial-mesenchymal transition in papillary thyroid carcinoma harbouring BRAF V600E mutation.

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  • معلومة اضافية
    • المصدر:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
    • بيانات النشر:
      Publication: Oxford, England : Wiley-Blackwell
      Original Publication: Bucharest : "Carol Davila" University Press, 2000-
    • الموضوع:
      Mutation*; Air Pollutants, Occupational/*adverse effects ; Benzhydryl Compounds/*adverse effects ; Epithelial-Mesenchymal Transition/*drug effects ; Epithelial-Mesenchymal Transition/*genetics ; Estrogens, Non-Steroidal/*adverse effects ; Phenols/*adverse effects ; Proto-Oncogene Proteins B-raf/*genetics; Adult ; Aged ; Alleles ; Biomarkers, Tumor ; Cell Movement/genetics ; Female ; Humans ; Immunohistochemistry ; MAP Kinase Signaling System ; Male ; Middle Aged ; Thyroid Cancer, Papillary/genetics ; Thyroid Cancer, Papillary/metabolism ; Thyroid Cancer, Papillary/pathology
    • نبذة مختصرة :
      Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, alters the function of endocrine system and enhances the susceptibility to tumorigenesis in several hormone-dependent tumours as thyroid carcinoma. About 50% of papillary thyroid cancers (PTC), the most common type of thyroid malignancy, harbours the BRAF V600E mutation. This study aimed to investigate a potential combined effect of BPA exposure and BRAF V600E mutation on epithelial-mesenchymal transition (EMT) in PTC. Firstly, the level of BPA in plasma, the evaluation of BRAF V600E mutation and the level of EMT-related proteins in PTC samples were individually determined. Additionally, the migration, invasion, colony formation capacity and the expression of EMT-related proteins after exposure to BPA were precisely analysed in vitro thyroid cells genetically modified by the introduction of BRAF V600E mutation. Moreover, ERK-Cox2 signalling pathway was also introduced to explore the possible mechanism in PTC development. As expected, whether the clinical investigation or cultured thyroid cells demonstrated that BPA at a concentration compatible with human exposed levels (10 -7  M) synergized with the BRAF V600E mutation promoted EMT via the activation of ERK-Cox2 signalling pathway. Our findings offer some evidence that BPA as an environmental risk factor can facilitate the progression of PTC harbouring BRAF V600E mutation.
      (© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
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    • Grant Information:
      NCC201806B009 National Cancer Center's "Climbing" Program; 2017225056 Liaoning Provincial Key Research and Development Program; ZF2019034 Liaoning Provincial Key Research and Development Program; 2019-ZD-0595 Provincial Natural Science Foundation of Liaoning; 81773470 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: BRAFV600E mutation; Bisphenol A; ERK-Cox2; Papillary thyroid carcinoma; epithelial-mesenchymal transition
    • الرقم المعرف:
      0 (Air Pollutants, Occupational)
      0 (Benzhydryl Compounds)
      0 (Biomarkers, Tumor)
      0 (Estrogens, Non-Steroidal)
      0 (Phenols)
      EC 2.7.11.1 (BRAF protein, human)
      EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
      MLT3645I99 (bisphenol A)
    • الموضوع:
      Date Created: 20210120 Date Completed: 20210922 Latest Revision: 20210922
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC7875916
    • الرقم المعرف:
      10.1111/jcmm.16279
    • الرقم المعرف:
      33469997