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Comparative analysis of visit and home blood pressure in a pilot trial on the effect of 18% sodium substitute salt on blood pressure.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Blood Pressure/*drug effects ; Blood Pressure Determination/*methods ; Blood Pressure Monitoring, Ambulatory/*methods ; Hypertension/*drug therapy ; Sodium/*administration & dosage; Aged ; Blood Pressure/physiology ; Diet, Sodium-Restricted/methods ; Female ; Humans ; Hypertension/physiopathology ; Male ; Middle Aged ; Pilot Projects
    • نبذة مختصرة :
      Aim to compare the home blood pressure monitoring (HBPM) and visit blood pressure monitoring in a clinical phase I single-arm pilot trial. The 18% sodium substitute salt was used in 43 hypertensives for 8 weeks, and visited once a week, while weekly visit blood (VBP) pressure, daily home blood pressure (HBP) and urine test results before and after intervention were collected. 43 hypertensive patients were recruited, 4 were lost. And enrolled 39 patients for analysis. The VBP were lower than morning HBP and night HBP (P < 0.05). And VBP was good correlated with morning BP (SBP: r = 0.692, P < 0.001, DBP: r = 0.789, P < 0.001) and night BP (SBP: r = 0.571, P < 0.001, DBP: r = 0.738, P < 0.001). The results of mixed linear model analysis showed that patients' visit SBP (- 11.4 mmHg, 95% CI: - 17.0 to - 5.7, P < 0.001), morning home SBP (- 10.0 mmHg, 95% CI: - 16.4 to - 3.6, P = 0.003) and night home SBP (- 10.2 mmHg, 95% CI: - 15.8 to - 4.6, P = 0.001) decreased significantly, after intervention. Both HBP and VBP showed that 18% substitute salt intervention could decrease the blood pressure of hypertensives. Medication led to VBP lower than HBP, but the two still had a good correlation.Trial registration: NCT03226327. Registered 21 July 2017-Retrospectively registered, http://www.clinicaltrials.gov .
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    • Molecular Sequence:
      ClinicalTrials.gov NCT03226327
    • الرقم المعرف:
      9NEZ333N27 (Sodium)
    • الموضوع:
      Date Created: 20210114 Date Completed: 20210817 Latest Revision: 20231110
    • الموضوع:
      20231110
    • الرقم المعرف:
      PMC7806920
    • الرقم المعرف:
      10.1038/s41598-020-79282-2
    • الرقم المعرف:
      33441669