Effect of Cavity Disinfectants on Dentin Bond Strength and Clinical Success of Composite Restorations-A Systematic Review of In Vitro, In Situ and Clinical Studies.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Anti-Infective Agents, Local/*pharmacology ; Composite Resins/*chemistry ; Dental Bonding/*methods ; Dentin/*drug effects ; Dentin-Bonding Agents/*chemistry ; Disinfectants/*pharmacology ; Disinfection/*methods; Humans ; Materials Testing

Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity disinfectants on restorations' adhesion and clinical success. A search was carried out through the Cochrane Library, PubMed, and Web of Science. In vitro and in situ studies reporting results on dentin bond strength tests, and clinical studies published until August 2020, in English, Spanish and Portuguese were included. The methodological quality assessment of the clinical studies was carried out using the Revised Cochrane risk-of-bias tool. Chlorhexidine could preserve adhesion to dentin. EDTA and ethanol had positive results that should be further confirmed. Given the significant lack of scientific evidence, the use of lasers, fluoridated agents, sodium hypochlorite, or other products as cavity disinfectants should be avoided. Chlorhexidine is a safe option for cavity disinfection with adequate preservation of adhesion to dentin. Moreover, future researches should be focused on the efficacy of these disinfectants against cariogenic bacteria and their best application methods.

Eur J Oral Sci. 2011 Feb;119(1):79-85. (PMID: 21244516)
J Mater Sci Mater Med. 2019 Nov 30;30(12):132. (PMID: 31786679)
Photomed Laser Surg. 2009 Jun;27(3):481-6. (PMID: 19405817)
Lasers Med Sci. 2019 Sep;34(7):1493-1501. (PMID: 30830558)
Braz Dent J. 2012;23(4):438-42. (PMID: 23207863)
Med Oral Patol Oral Cir Bucal. 2012 Jul 01;17(4):e649-54. (PMID: 22322501)
Oper Dent. 2014 Jan-Feb;39(1):64-71. (PMID: 23675741)
Oper Dent. 2002 Sep-Oct;27(5):528-34. (PMID: 12216574)
J Dent (Shiraz). 2019 Dec;20(4):264-270. (PMID: 31875173)
Braz Oral Res. 2008 Oct-Dec;22(4):352-7. (PMID: 19148392)
Niger J Clin Pract. 2020 Feb;23(2):165-171. (PMID: 32031090)
Arch Oral Biol. 2009 Aug;54(8):790-5. (PMID: 19482262)
J Adhes Dent. 2016;18(1):35-42. (PMID: 26814314)
J Dent (Shiraz). 2019 Mar;20(1):30-36. (PMID: 30937334)
J Dent. 2015 Aug;43(8):973-80. (PMID: 26054235)
Anaesth Intensive Care. 2008 Jul;36(4):502-12. (PMID: 18714617)
Lasers Med Sci. 2019 Sep;34(7):1391-1399. (PMID: 30762196)
Am J Dent. 2013 Jun;26(3):121-6. (PMID: 23986957)
Am J Dent. 2005 Jun;18(3):165-7. (PMID: 16158806)
Saudi Med J. 2011 May;32(5):479-83. (PMID: 21556468)
J Dent Res. 2014 Aug;93(8):733-43. (PMID: 24935066)
Scanning. 2016 Nov;38(6):535-544. (PMID: 26763084)
Oper Dent. 2006 Sep-Oct;31(5):530-5. (PMID: 17024939)
Oper Dent. 2010 Nov-Dec;35(6):618-23. (PMID: 21180000)
Dent Mater. 2005 Jul;21(7):616-24. (PMID: 15978270)
J Dent. 2014 Jul;42(7):816-23. (PMID: 24739486)
Photomed Laser Surg. 2006 Dec;24(6):730-4. (PMID: 17199473)
J Biomed Mater Res. 2002 May;60(2):316-24. (PMID: 11857439)
Quintessence Int. 2004 Jun;35(6):469-76. (PMID: 15202592)
J Adhes Dent. 2017 Dec 21;:517-523. (PMID: 29292408)
J Adhes Dent. 2013 Dec;15(6):535-40. (PMID: 23560257)
Oper Dent. 1996 Jul-Aug;21(4):153-9. (PMID: 8957905)
J Contemp Dent Pract. 2009 Jan 01;10(1):41-8. (PMID: 19142255)
J Dent (Shiraz). 2020 Jun;21(2):111-118. (PMID: 32582826)
J Dent. 2013 Dec;41(12):1188-95. (PMID: 24076103)
Aust Dent J. 2015 Sep;60(3):276-93. (PMID: 25790344)
Photomed Laser Surg. 2010 Feb;28(1):97-102. (PMID: 19743929)
J Contemp Dent Pract. 2013 Mar 01;14(2):275-80. (PMID: 23811659)
Acta Odontol Scand. 2006 Aug;64(4):237-43. (PMID: 16829500)
Mol Biol Rep. 2013 Dec;40(12):7053-9. (PMID: 24190486)
Braz Oral Res. 2016 Nov 28;30(1):e115. (PMID: 27901199)
Int J Paediatr Dent. 2018 Mar;28(2):123-139. (PMID: 29322626)
J Biomed Mater Res B Appl Biomater. 2005 Oct;75(1):158-67. (PMID: 16015618)
Oper Dent. 2011 Nov-Dec;36(6):649-60. (PMID: 21864128)
Restor Dent Endod. 2019 Mar 29;44(2):e13. (PMID: 31149611)
Oral Microbiol Immunol. 1995 Dec;10(6):360-4. (PMID: 8602344)
Int J Periodontics Restorative Dent. 2013 May-Jun;33(3):373-7. (PMID: 23593631)
Dent Mater J. 2016;35(1):147-52. (PMID: 26830836)
Quintessence Int. 2017;48(7):585-591. (PMID: 28555200)
Gen Dent. 2016 Mar-Apr;64(2):14-7. (PMID: 26943082)
J Oral Rehabil. 2004 May;31(5):492-9. (PMID: 15140176)
J Dent. 2009 Feb;37(2):108-14. (PMID: 19022552)
Arch Oral Biol. 1983;28(3):233-40. (PMID: 6574734)
Photomed Laser Surg. 2010 Apr;28(2):267-72. (PMID: 19530908)
J Adhes Dent. 2012 Dec;14(6):575-83. (PMID: 23240110)
Lasers Med Sci. 2017 Dec;32(9):1981-1993. (PMID: 28812169)
J Dent Res. 1996 Jan;75(1):599-605. (PMID: 8655766)
Microsc Res Tech. 2014 Jan;77(1):37-43. (PMID: 24185754)
J Oral Rehabil. 1999 Oct;26(10):836-40. (PMID: 10564442)
J Adhes Dent. 2012 Aug;14(4):363-70. (PMID: 22282748)
Braz Oral Res. 2011 Sep-Oct;25(5):459-65. (PMID: 22031061)
J Conserv Dent. 2018 Jul-Aug;21(4):424-427. (PMID: 30122825)
J Clin Pediatr Dent. 2000 Fall;25(1):57-63. (PMID: 11314354)
Eur J Dent. 2018 Jan-Mar;12(1):105-110. (PMID: 29657533)
Lasers Surg Med. 2016 Jan;48(1):62-9. (PMID: 26729655)
J Biomed Mater Res A. 2008 Aug;86(2):477-82. (PMID: 17975814)
Caries Res. 2004 May-Jun;38(3):305-13. (PMID: 15153704)
Lasers Med Sci. 2010 Nov;25(6):849-54. (PMID: 19655225)
Oper Dent. 2011 Sep-Oct;36(5):537-44. (PMID: 21859314)
J Biomed Opt. 2011 Jul;16(7):071410. (PMID: 21806256)
Photomed Laser Surg. 2012 Feb;30(2):71-6. (PMID: 22070178)
J Contemp Dent Pract. 2018 Nov 1;19(11):1404-1411. (PMID: 30602649)
Eur J Dent. 2014 Apr;8(2):184-190. (PMID: 24966768)
J Dent. 2008 Dec;36(12):1068-73. (PMID: 18922612)
J Appl Oral Sci. 2003 Sep;11(3):223-8. (PMID: 21394397)
Dent Mater. 2013 Jun;29(6):682-92. (PMID: 23582694)
Oper Dent. 2016 Sep-Oct;41(5):511-519. (PMID: 26918930)
Int Endod J. 2007 Feb;40(2):85-93. (PMID: 17229112)
J Dent. 2003 Feb;31(2):127-35. (PMID: 12654552)
J Appl Oral Sci. 2018 Dec 10;27:e20180126. (PMID: 30540073)
Braz Oral Res. 2015;29:1-5. (PMID: 25466328)
Int J Clin Pediatr Dent. 2017 Jul-Sep;10(3):223-228. (PMID: 29104379)
J Dent. 2010 Mar;38(3):261-8. (PMID: 19945497)
J Prosthet Dent. 2000 Sep;84(3):280-8. (PMID: 11005900)
Lasers Med Sci. 2008 Apr;23(2):117-24. (PMID: 17479311)
J Clin Laser Med Surg. 2002 Apr;20(2):89-93. (PMID: 12017433)
Dent Mater. 2014 Jul;30(7):735-41. (PMID: 24815823)
Microsc Res Tech. 2020 Feb;83(2):186-195. (PMID: 31701615)
Dent Res J (Isfahan). 2014 Nov;11(6):689-94. (PMID: 25540665)
J Adhes Dent. 2009 Jun;11(3):191-8. (PMID: 19603582)
J Oral Sci. 2020 Mar 28;62(2):206-211. (PMID: 32161231)
Oper Dent. 2009 Jul-Aug;34(4):481-90. (PMID: 19678455)
Oper Dent. 2005 Mar-Apr;30(2):170-9. (PMID: 15853101)
J Dent (Shiraz). 2017 Jun;18(2):82-87. (PMID: 28620631)
J Dent Res Dent Clin Dent Prospects. 2013;7(2):67-73. (PMID: 23875083)
J Adhes Dent. 2009 Oct;11(5):343-6. (PMID: 19841759)
J Appl Oral Sci. 2009 Sep-Oct;17(5):462-6. (PMID: 19936527)
Eur J Oral Sci. 2011 Feb;119(1):86-92. (PMID: 21244517)
BMC Oral Health. 2019 Oct 7;19(1):216. (PMID: 31590650)
J Contemp Dent Pract. 2016 Oct 1;17(10):867-879. (PMID: 27794161)
J Conserv Dent. 2013 Jul;16(4):367-70. (PMID: 23956543)
Oral Health Prev Dent. 2020;18(1):71-76. (PMID: 32051973)
J Adhes Dent. 2012 Apr;14(2):137-45. (PMID: 21734971)
J Lasers Med Sci. 2016 Summer;7(3):167-171. (PMID: 28144437)
Eur J Oral Sci. 2009 Oct;117(5):587-96. (PMID: 19758257)
Lasers Surg Med. 2002;31(3):164-70. (PMID: 12224089)
Photomed Laser Surg. 2013 Mar;31(3):116-24. (PMID: 23421630)
Lasers Med Sci. 2017 Jul;32(5):967-974. (PMID: 28357598)
BMJ. 2019 Aug 28;366:l4898. (PMID: 31462531)
Microsc Res Tech. 2013 Jan;76(1):72-8. (PMID: 23077029)
Photomed Laser Surg. 2008 Oct;26(5):495-500. (PMID: 18800947)
Lasers Med Sci. 2013 Jul;28(4):1069-76. (PMID: 22886136)
Photodiagnosis Photodyn Ther. 2020 Sep;31:101875. (PMID: 32534249)
Int Dent J. 2000 Dec;50(6):361-6. (PMID: 11197194)
Am J Dent. 2002 Aug;15(4):252-5. (PMID: 12572644)
Contemp Clin Dent. 2011 Jul;2(3):155-9. (PMID: 22090756)
Braz Dent J. 2004;15 Spec No:SI9-20. (PMID: 15690766)
Int J Mol Sci. 2015 Mar 02;16(3):4615-27. (PMID: 25739078)
Heliyon. 2020 Apr 28;6(4):e03871. (PMID: 32373750)
Eur J Oral Sci. 1997 Oct;105(5 Pt 2):473-7. (PMID: 9395112)
J Appl Oral Sci. 2006 Dec;14(6):399-404. (PMID: 19089238)
J Conserv Dent. 2013 May;16(3):243-6. (PMID: 23833459)
Am J Dent. 1994 Apr;7(2):81-4. (PMID: 8054190)
Photomed Laser Surg. 2011 Nov;29(11):747-52. (PMID: 21923283)
J Adhes Dent. 2003 Summer;5(2):129-38. (PMID: 14964680)
Eur J Dent. 2015 Apr-Jun;9(2):262-266. (PMID: 26038661)
J Dent. 2017 May;60:44-49. (PMID: 28237629)
J Adhes Dent. 2013 Jun;15(3):287-92. (PMID: 23560258)
J Esthet Dent. 1992;4 Suppl:11-3. (PMID: 1298316)
Dent Mater. 1999 Sep;15(5):323-31. (PMID: 10863428)
J Contemp Dent Pract. 2016 Dec 1;17(12):985-989. (PMID: 27965484)
Dent Mater J. 2017 May 31;36(3):368-373. (PMID: 28450671)
Lasers Med Sci. 2015 Feb;30(2):483-92. (PMID: 23677437)
Braz Dent J. 2015 May-Jun;26(3):234-41. (PMID: 26200146)
Oper Dent. 2017 Jan/Feb;42(1):62-72. (PMID: 27689772)
Indian J Dent Res. 2015 Jul-Aug;26(4):416-20. (PMID: 26481891)
Niger J Clin Pract. 2019 Dec;22(12):1758-1764. (PMID: 31793485)
Indian J Dent Res. 2018 Mar-Apr;29(2):133-136. (PMID: 29652002)
Lasers Med Sci. 2015 Feb;30(2):695-700. (PMID: 23912781)
J Conserv Dent. 2015 Sep-Oct;18(5):360-3. (PMID: 26430297)
J Conserv Dent. 2016 Sep-Oct;19(5):406-9. (PMID: 27656056)
J Adhes Dent. 2008 Dec;10(6):419-22. (PMID: 19189671)
Caries Res. 1981;15(6):468-76. (PMID: 7030490)
Oper Dent. 2016 May-Jun;41(3):258-67. (PMID: 26919083)
J Biomed Opt. 2016 Apr 30;21(4):48001. (PMID: 27086692)
J Dent Res. 1981 Nov;60(11):1842-8. (PMID: 6945323)
Proc SPIE Int Soc Opt Eng. 2009 Feb 18;7162:71620F. (PMID: 21892256)
Lasers Med Sci. 2012 Jul;27(4):819-25. (PMID: 21915687)
Dent Mater J. 2007 Jan;26(1):116-21. (PMID: 17410901)
J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S325-S330. (PMID: 31198363)
J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):177-84. (PMID: 22102416)
Eur J Oral Sci. 2002 Aug;110(4):322-9. (PMID: 12206595)
Dent Mater. 2012 Jan;28(1):87-101. (PMID: 22192253)
Lasers Med Sci. 2010 Jul;25(4):511-6. (PMID: 19475475)
J Dent. 2009 Apr;37(4):279-88. (PMID: 19155116)
Photomed Laser Surg. 2005 Apr;23(2):229-32. (PMID: 15910193)
J Clin Exp Dent. 2015 Dec 01;7(5):e595-9. (PMID: 26644835)
Lasers Med Sci. 2012 Jan;27(1):15-21. (PMID: 20809080)
J Dent Res. 2002 Feb;81(2):119-22. (PMID: 11827256)
J Dent. 2011 Jan;39(1):40-7. (PMID: 20937350)
Braz Oral Res. 2017 Jan 05;31:e2. (PMID: 28076495)
Lasers Med Sci. 2010 Mar;25(2):181-9. (PMID: 18716826)
J Adhes Dent. 2008 Feb;10(2):135-44. (PMID: 18512511)
Niger J Clin Pract. 2017 Oct;20(10):1277-1282. (PMID: 29192632)
J Adhes Dent. 2011 Apr;13(2):111-5. (PMID: 21594223)
Quintessence Int. 2004 Jan;35(1):56-60. (PMID: 14765642)
Braz Dent J. 2015 Nov-Dec;26(6):642-7. (PMID: 26963210)
Oper Dent. 2015 Jan-Feb;40(1):80-6. (PMID: 24815915)
Oper Dent. 2006 Sep-Oct;31(5):604-9. (PMID: 17024950)
J Dent Res. 2005 Aug;84(8):736-40. (PMID: 16040732)

Keywords: adhesion; antimicrobial substances; bonding; cavity disinfection; chlorhexidine; dental caries

0 (Anti-Infective Agents, Local)
0 (Composite Resins)
0 (Dentin-Bonding Agents)
0 (Disinfectants)

Date Created: 20210105 Date Completed: 20210325 Latest Revision: 20210325

20221213

PMC7794949

10.3390/ijms22010353

33396354