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CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: S. Karger Country of Publication: Switzerland NLM ID: 9007504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0291 (Electronic) Linking ISSN: 10152008 NLM ISO Abbreviation: Pathobiology Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel ; New York : S. Karger, c1990-
    • الموضوع:
      Genetic Predisposition to Disease* ; Polymorphism, Genetic*; Lymphoma, Large B-Cell, Diffuse/*genetics ; Lymphoma, Large B-Cell, Diffuse/*immunology ; Receptors, CXCR5/*genetics; Adult ; Cohort Studies ; Egypt ; Female ; Genotype ; Genotyping Techniques ; Humans ; Male ; Middle Aged ; Receptors, CXCR5/classification ; Risk Factors
    • نبذة مختصرة :
      Background: The chemokine receptor CXCR5 is selectively expressed on B cells; it is involved in lymphocyte homing and the development of normal lymphoid tissue. Its principle ligand is CXCL13 or B lymphocyte chemoattractant. Three polymorphisms in the CXCR5 gene, rs148351692 C/G, rs6421571 C/T, and rs78440425 G/A, have been identified.
      Objective: To assess the genetic polymorphisms of CXCR5 and evaluate their possible contribution to the susceptibility and response to therapy of diffuse large B-cell lymphoma (DLBCL).
      Patients and Methods: Fifty DLBCL (not otherwise specified) patients and 50 control subjects were included in this study. CXCR5 genotypes were determined by PCR-RFLP.
      Results: Our study revealed that the CXCR5 rs148351692 C/G and rs6421571 C/T gene polymorphisms are associated with an increased risk of developing DLBCL (OR 28.57 [95% CI 8.96-96.56] and 3.45 [1.67-11.83] respectively), while CXCR5 rs78440425 G/A showed no association with the risk of lymphoma. Moreover, the double and triple combined gene polymorphisms are associated with an increased risk of developing DLBCL of approximately 120-fold and 105-fold, respectively. CXCR5 gene polymorphisms had no significant impact on disease outcome or response to therapy.
      Conclusions: CXCR5 gene polymorphisms could be considered a potential risk factor for the development of DLBCL.
      (© 2020 S. Karger AG, Basel.)
    • Contributed Indexing:
      Keywords: CXCR5 rs148351692 C/G; DLBCL; PCR-RFLP; rs6421571 C/T; rs78440425 G/A
    • الرقم المعرف:
      0 (Receptors, CXCR5)
    • الموضوع:
      Date Created: 20201230 Date Completed: 20211013 Latest Revision: 20211013
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1159/000510456
    • الرقم المعرف:
      33378752