Synthetic Scaffold/Dental Pulp Stem Cell (DPSC) Tissue Engineering Constructs for Bone Defect Treatment: An Animal Studies Literature Review.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Bone Regeneration* ; Cell Differentiation*; Bone Diseases/*therapy ; Dental Pulp/*cytology ; Stem Cells/*cytology ; Tissue Engineering/*methods ; Tissue Scaffolds/*chemistry; Animals ; Humans

Background: Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo articles.
Methods: The electronic database and manual search was conducted on Pubmed, Scopus, and EMBASE. The papers identified were submitted for risk-of-bias assessment and classified according to new bone formation, bone graft characteristics, dental pulp stem cells (DPSCs) culture passages and amount of experimental data. The meta-analysis assessment was conducted to assess new bone formation in test sites with DPSCs/synthetic blocks vs. synthetic block alone.
Results: The database search identified a total of 348 papers. After the initial screening, 30 studies were included, according to the different animal models: 19 papers on rats, 3 articles on rabbits, 2 manuscripts on sheep and 4 papers on swine. The meta-analysis evaluation showed a significantly increase in new bone formation in favor of DPSCs/synthetic scaffold complexes, if compared to the control at 4 weeks (Mean Diff: 17.09%, 95% CI: 15.16-18.91%, p < 0.01) and at 8 weeks (Mean Diff: 14.86%, 95% CI: 1.82-27.91%, p < 0.01) in rats calvaria bone defects.
Conclusion: The synthetic scaffolds in association of DPSCs used for the treatment of bone defects showed encouraging results of early new bone formation in preclinical animal studies and could represent a useful resource for regenerative bone augmentation procedures.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Oct;110(4):418-21; author reply 421-2. (PMID: 20868991)
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Oct;110(4):409-11; author reply 411-3. (PMID: 20868988)
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1577-1584. (PMID: 31027424)
Stem Cells. 2019 May;37(5):701-711. (PMID: 30674073)
Int J Mol Med. 2018 Oct;42(4):1967-1976. (PMID: 30085338)
Implant Dent. 2006 Mar;15(1):8-17. (PMID: 16569956)
Stem Cell Rev. 2008 Spring;4(1):21-6. (PMID: 18300003)
Dent Clin North Am. 2017 Oct;61(4):835-856. (PMID: 28886771)
BMC Med. 2011 May 31;9:66. (PMID: 21627784)
J Dent Res. 2009 Mar;88(3):249-54. (PMID: 19329459)
Int J Mol Sci. 2019 Feb 08;20(3):. (PMID: 30744023)
Int J Mol Sci. 2019 Aug 28;20(17):. (PMID: 31466409)
Biomed Res Int. 2016;2016:2078104. (PMID: 27478828)
J Craniofac Surg. 2015 May;26(3):737-40. (PMID: 25974782)
Oral Maxillofac Surg Clin North Am. 2007 Nov;19(4):455-66, v. (PMID: 18088897)
Oral Dis. 2018 Jul;24(5):696-705. (PMID: 28636235)
Biomed Res Int. 2018 Jun 27;2018:2349698. (PMID: 30050922)
Stem Cell Res Ther. 2016 Sep 09;7(1):130. (PMID: 27613503)
J Craniofac Surg. 2013 May;24(3):866-71. (PMID: 23714898)
Int J Oral Maxillofac Surg. 2002 Feb;31(1):73-7. (PMID: 11936404)
Tissue Eng Part B Rev. 2019 Oct;25(5):445-460. (PMID: 31179893)
Biomolecules. 2019 Nov 19;9(11):. (PMID: 31752393)
Curr Stem Cell Res Ther. 2014;9(4):330-7. (PMID: 24588088)
J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):273-81. (PMID: 26122214)
J Biomed Mater Res B Appl Biomater. 2014 May;102(4):815-25. (PMID: 24142538)
Methods Mol Biol. 2014;1210:91-115. (PMID: 25173163)
Int J Mol Sci. 2019 Oct 10;20(20):. (PMID: 31658685)
J Dent Res. 2016 Feb;95(2):206-14. (PMID: 26494655)
Materials (Basel). 2018 Dec 11;11(12):. (PMID: 30544962)
Front Physiol. 2017 Aug 03;8:565. (PMID: 28824459)
J Craniomaxillofac Surg. 2015 May;43(4):483-90. (PMID: 25753474)
Acta Biomater. 2011 Aug;7(8):3222-9. (PMID: 21549863)
Stem Cells Int. 2016;2016:8035759. (PMID: 27648077)
J Cell Physiol. 2006 Aug;208(2):319-25. (PMID: 16622855)
J Biomed Mater Res A. 2013 Jan;101(1):298-306. (PMID: 23065737)
J Mater Sci Mater Med. 2017 May;28(5):77. (PMID: 28386853)
Biomater Sci. 2016 Oct 18;4(11):1596-1604. (PMID: 27722231)
Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1626-1633. (PMID: 30840286)
Stem Cell Res Ther. 2013 May 21;4(3):53. (PMID: 23688855)
Plast Reconstr Surg. 2010 Jun;125(6):1685-92. (PMID: 20517092)
J Biol Regul Homeost Agents. 2019 Nov-Dec;33(6 Suppl. 2):143-154. (PMID: 32425035)
J Dent Educ. 2003 Aug;67(8):932-49. (PMID: 12959168)
Oral Maxillofac Surg. 2020 Aug 15;:. (PMID: 32803459)
Sci Rep. 2015 Aug 03;5:12721. (PMID: 26234712)
Biomed Res Int. 2019 Sep 29;2019:8483658. (PMID: 31662998)
Int J Mol Sci. 2018 Apr 18;19(4):. (PMID: 29670035)
J Dent. 2014 Jul;42(7):761-8. (PMID: 24589847)
Stem Cell Rev Rep. 2016 Oct;12(5):511-523. (PMID: 27240827)
J Appl Oral Sci. 2019;27:e20180103. (PMID: 30994771)
J Oral Maxillofac Surg. 2016 Apr;74(4):829.e1-9. (PMID: 26763080)
Oral Dis. 2020 Mar;26(2):381-390. (PMID: 31808229)
Regen Biomater. 2019 Feb;6(1):49-59. (PMID: 30740242)
Stem Cells Transl Med. 2019 Aug;8(8):844-857. (PMID: 31016898)
Plast Reconstr Surg. 2012 Jun;129(6):1314-20. (PMID: 22634648)
J Endod. 2019 Apr;45(4):435-441. (PMID: 30851933)
J Endod. 2019 Apr;45(4):420-426. (PMID: 30819529)
Eur Rev Med Pharmacol Sci. 2019 Oct;23(20):8730-8740. (PMID: 31696459)
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30. (PMID: 11087820)
J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6):1589-1592. (PMID: 30574770)
Int J Environ Res Public Health. 2018 Jun 16;15(6):. (PMID: 29914159)
Tissue Eng Part A. 2011 Oct;17(19-20):2417-33. (PMID: 21563858)
Oral Maxillofac Surg. 2020 Jul 29;:. (PMID: 32725574)
Int J Environ Res Public Health. 2020 Mar 21;17(6):. (PMID: 32245226)
Tissue Eng Regen Med. 2019 Mar 11;16(2):191-200. (PMID: 30989045)
J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):603-14. (PMID: 22217992)
J Biomed Mater Res B Appl Biomater. 2017 Jul;105(5):953-965. (PMID: 26856387)
Connect Tissue Res. 2015 Jun;56(3):175-94. (PMID: 25803622)
J Stomatol Oral Maxillofac Surg. 2019 Jun;120(3):216-223. (PMID: 30579853)
Int J Periodontics Restorative Dent. 2016 Sep-Oct;36(5):745-54. (PMID: 27560680)
Eur Rev Med Pharmacol Sci. 2018 Dec;22(23):8497-8501. (PMID: 30556892)
Dent Mater. 2011 Jan;27(1):61-70. (PMID: 21112618)
Biomed Res Int. 2017;2017:7102123. (PMID: 29018818)
Eur J Oral Implantol. 2014 Summer;7 Suppl 2:S203-17. (PMID: 24977256)
J Biomater Appl. 2018 Oct;33(4):477-487. (PMID: 30217134)
Int J Med Sci. 2014 May 01;11(7):674-9. (PMID: 24843315)
Stem Cells Int. 2017;2017:9082869. (PMID: 28553359)
J Oral Implantol. 2013 Aug;39(4):433-43. (PMID: 23964777)
Macromol Biosci. 2018 Aug;18(8):e1800112. (PMID: 29920937)
Mater Sci Eng C Mater Biol Appl. 2015 May;50:19-23. (PMID: 25746240)
Int J Med Sci. 2012;9(6):480-7. (PMID: 22927773)
Rom J Morphol Embryol. 2013;54(3):473-8. (PMID: 24068393)
Materials (Basel). 2018 Aug 17;11(8):. (PMID: 30126102)
Biomed Res Int. 2016;2016:4086870. (PMID: 27413746)
World Neurosurg. 2018 Sep;117:443-452.e8. (PMID: 29879511)
J Oral Implantol. 2020 Aug 11;:. (PMID: 32780812)
Tissue Eng Part A. 2016 Jul;22(13-14):985-93. (PMID: 27369635)
Materials (Basel). 2020 Aug 15;13(16):. (PMID: 32824141)
Biomaterials. 2016 Dec;111:103-115. (PMID: 27728810)
PLoS One. 2012;7(11):e50542. (PMID: 23209773)
J Biomater Appl. 2019 Aug;34(2):261-272. (PMID: 31027447)
Arch Oral Biol. 2015 Dec;60(12):1729-35. (PMID: 26433189)
Odontology. 2011 Jan;99(1):1-7. (PMID: 21271319)
J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):901-910. (PMID: 29254292)
Eur Cell Mater. 2009 Nov 12;18:75-83. (PMID: 19908196)
Spine J. 2018 Jun;18(6):1070-1080. (PMID: 29452287)
Biomed Res Int. 2017;2017:8724951. (PMID: 29445746)

Keywords: bone regeneration; dental pulp stem cells; synthetic scaffold; tissue engineering

Date Created: 20201229 Date Completed: 20210402 Latest Revision: 20210402

20231215

PMC7767470

10.3390/ijms21249765

33371390