Can Methotrexate be a successful treatment for unresponsive generalized annular elastolytic giant cell granuloma? Case report and review of the literature.

Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9700070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-8019 (Electronic) Linking ISSN: 13960296 NLM ISO Abbreviation: Dermatol Ther Subsets: MEDLINE

Publication: July/Aug. 2008- : Hoboken, NJ : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard, c1996-

Granuloma Annulare*/diagnosis ; Granuloma Annulare*/drug therapy ; Granuloma, Giant Cell*/diagnosis ; Granuloma, Giant Cell*/drug therapy ; Skin Diseases*; Aged ; Humans ; Methotrexate/therapeutic use ; Skin

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disorder, characterized by erythematous plaques with elevated borders and hypopigmented center, occurring mainly on sun exposed-skin. Histologically it presents with elastophagocytosis and elastolysis. There is no established first line treatment for AEGCG, especially for the generalized form. In a small number of cases, antimalarial drugs and tranilast, associated to topical or oral steroids, have been proposed to treat generalized AEGCG with partial benefits. We herein present the case of a patient with AEGCG aged 74 years, who was unresponsive to classical therapies, and then successfully treated with methotrexate.
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Keywords: generalized annular elastolytic giant cell granuloma; methotrexate; unresponsiveness to therapy

YL5FZ2Y5U1 (Methotrexate)

Date Created: 20201228 Date Completed: 20210524 Latest Revision: 20210524

20240628

10.1111/dth.14705

33369018