Shape analysis of rectus extraocular muscles with age and axial length using anterior segment optical coherence tomography.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Tomography, Optical Coherence*; Aging/*physiology ; Anterior Eye Segment/*diagnostic imaging ; Oculomotor Muscles/*diagnostic imaging; Adolescent ; Adult ; Aged ; Anterior Eye Segment/physiology ; Child ; Female ; Humans ; Japan/epidemiology ; Limbus Corneae/diagnostic imaging ; Limbus Corneae/physiology ; Male ; Middle Aged ; Oculomotor Muscles/physiology ; Young Adult

Purpose: This study aimed to evaluate the shape of the extraocular muscles (EOMs) in normal subjects using the en-face images of anterior segment optical coherence tomography (AS-OCT). The EOM insertion and the direction of the muscle fibers were investigated.
Subjects and Methods: A total of 97 healthy normal subjects (194 eyes) at Okayama University Hospital (age, 47.1±21.5 years; range, 8-79 years) participated in the study. A series of 256 tomographic images of the rectus EOMs were captured using the C-scan function of the AS-OCT (CASIA2, TOMEY Co., Japan), and the images were converted to en-face images in multi-TIFF format. The anterior chamber angle to EOM insertion distance (AID) and the angle of the muscle fibers from the insertion site (angle of muscles) were measured from the images. The correlations of AID and angle of muscles with age and axial length were investigated and evaluated.
Results: AID and angle of muscles were significantly correlated with age or axial length in some EOMs. The AIDs of medial rectus (MR) (P = 0.000) and superior rectus (SR) (P = 0.005) shortened with age. The AIDs of MR (P = 0.001) and inferior rectus (IR) (P = 0.035) elongated with axial length, whereas lateral rectus (LR) (P = 0.013) shortened. The angles of MR (P = 0.001) and LR (P = 0.000) were found to have a more downward direction toward the posterior in older subjects.
Conclusion: En-face images can be created by AS-OCT, and the shape of the EOMs in normal subjects using these image measurements was available. With the ability to assess the EOMs, AID and angle of muscles are expected give useful information for treating and diagnosing strabismus-related diseases.
Competing Interests: The authors have declared that no competing interests exist.

J AAPOS. 2014 Feb;18(1):15-20. (PMID: 24568976)
Jpn J Ophthalmol. 2018 Sep;62(5):554-559. (PMID: 29980870)
Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):6. (PMID: 32271887)
Folia Morphol (Warsz). 2017 Mar 10;:. (PMID: 28281723)
Int Ophthalmol. 2019 May;39(5):1037-1042. (PMID: 29582257)
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):618-22. (PMID: 12556391)
J Med Dent Sci. 2010 Mar;57(1):75-82. (PMID: 20437768)
Am J Ophthalmol. 2002 Dec;134(6):872-8. (PMID: 12470756)
JAMA Ophthalmol. 2013 May;131(5):619-25. (PMID: 23471194)
Eye (Lond). 2017 Nov;31(11):1556-1561. (PMID: 28622324)
J Pediatr Ophthalmol Strabismus. 2016 May 1;53(3):141-5. (PMID: 27224947)
Invest Ophthalmol Vis Sci. 2011 Oct 28;52(11):8370-3. (PMID: 21948556)
Br J Ophthalmol. 2012 May;96(5):679-82. (PMID: 22241925)
J Clin Med. 2019 Oct 19;8(10):. (PMID: 31635030)
Korean J Ophthalmol. 2018 Apr;32(2):83-88. (PMID: 29560615)
J AAPOS. 2015 Jun;19(3):233-6. (PMID: 26059668)
J AAPOS. 2015 Dec;19(6):500-6. (PMID: 26691027)
Graefes Arch Clin Exp Ophthalmol. 2019 Mar;257(3):657-662. (PMID: 30671656)
Am J Ophthalmol. 2020 Jan;209:55-61. (PMID: 31526795)
Anat Cell Biol. 2015 Sep;48(3):201-4. (PMID: 26417480)

Date Created: 20201228 Date Completed: 20210125 Latest Revision: 20210125

20250114

PMC7757803

10.1371/journal.pone.0243382

33362229