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Subjective sleep parameters in prodromal Alzheimer's disease: a case-control study.

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  • معلومة اضافية
    • المصدر:
      Publisher: Associação Brasileira de Psiquiatria Country of Publication: Brazil NLM ID: 100895975 Publication Model: Print Cited Medium: Internet ISSN: 1809-452X (Electronic) Linking ISSN: 15164446 NLM ISO Abbreviation: Braz J Psychiatry Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: São Paulo, SP, Brasil : Associação Brasileira de Psiquiatria, [1999]-
    • الموضوع:
      Alzheimer Disease*/diagnostic imaging ; Cognitive Dysfunction*/diagnostic imaging; Aged ; Aniline Compounds ; Case-Control Studies ; Humans ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Sleep ; Thiazoles
    • نبذة مختصرة :
      Objective: People with Alzheimer's disease (AD) dementia have impaired sleep. However, the characteristics of sleep in the early stages of AD are not well known, and studies with the aid of biomarkers are lacking. We assessed the subjective sleep characteristics of non-demented older adults and compared their amyloid profiles.
      Methods: We enrolled 30 participants aged ≥ 60 years, with no dementia or major clinical and psychiatric diseases. They underwent [11C]PiB-PET-CT, neuropsychological evaluations, and completed two standardized sleep assessments (Pittsburgh Sleep Quality Inventory and Epworth Sleep Scale).
      Results: Comparative analysis of subjective sleep parameters across the two groups showed longer times in bed (p = 0.024) and reduced sleep efficiency (p = 0.05) in individuals with positive amyloid. No differences in other subjective sleep parameters were observed. We also found that people with multiple-domain mild cognitive impairment (MCI) had shorter self-reported total sleep times (p = 0.034) and worse overall sleep quality (p = 0.027) compared to those with single-domain MCI.
      Conclusions: Older adults testing positive for amyloid had a longer time in bed and lower sleep efficiency, regardless of cognitive status. In parallel, individuals with multiple-domain MCI reported shorter sleep duration and lower overall sleep quality.
    • الرقم المعرف:
      0 (Aniline Compounds)
      0 (Thiazoles)
    • الموضوع:
      Date Created: 20201217 Date Completed: 20211118 Latest Revision: 20211118
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC8555634
    • الرقم المعرف:
      10.1590/1516-4446-2020-1503
    • الرقم المعرف:
      33331534