Gray matter declines with age and hearing loss, but is partially maintained in tinnitus.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Aging* ; Cognitive Dysfunction*/diagnostic imaging ; Cognitive Dysfunction*/physiopathology ; Deafness*/diagnostic imaging ; Deafness*/physiopathology ; Gray Matter*/diagnostic imaging ; Gray Matter*/physiopathology ; Magnetic Resonance Imaging* ; Tinnitus*/diagnostic imaging ; Tinnitus*/physiopathology; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged

The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline.

Erratum in: Sci Rep. 2021 Apr 13;11(1):8466. doi: 10.1038/s41598-021-88182-y. (PMID: 33850261)

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Date Created: 20201214 Date Completed: 20210427 Latest Revision: 20210803

20250114

PMC7732822

10.1038/s41598-020-78571-0

33311548