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Dissecting the complexity of biomolecular condensates.

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  • المؤلفون: Swain P;Swain P; Weber SC; Weber SC; Weber SC
  • المصدر:
    Biochemical Society transactions [Biochem Soc Trans] 2020 Dec 18; Vol. 48 (6), pp. 2591-2602.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Portland Press On The Behalf Of The Biochemical Society
    • الموضوع:
      Biophysics*; Biopolymers/*chemistry ; Cell Nucleus/*metabolism ; Endoplasmic Reticulum/*metabolism ; Golgi Apparatus/*metabolism; Animals ; Computer Simulation ; Cytoplasm/metabolism ; Gene Expression Profiling ; Humans ; Kinetics ; Neurodegenerative Diseases/metabolism ; Polymers/chemistry ; RNA, Ribosomal/metabolism ; Ribosomes/metabolism ; Signal Transduction
    • نبذة مختصرة :
      Biomolecular condensates comprise a diverse and ubiquitous class of membraneless organelles. Condensate assembly is often described by liquid-liquid phase separation. While this process explains many key features, it cannot account for the compositional or architectural complexity that condensates display in cells. Recent work has begun to dissect the rich network of intermolecular interactions that give rise to biomolecular condensates. Here, we review the latest results from theory, simulations and experiments, and discuss what they reveal about the structure-function relationship of condensates.
      (© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
    • Contributed Indexing:
      Keywords: associative polymers; biomolecular condensates; liquid–liquid phase separation; multiphase organization; network connectivity; non-equilibrium activity
    • الرقم المعرف:
      0 (Biopolymers)
      0 (Polymers)
      0 (RNA, Ribosomal)
    • الموضوع:
      Date Created: 20201210 Date Completed: 20210809 Latest Revision: 20210809
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1042/BST20200351
    • الرقم المعرف:
      33300985