The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c2000-

Nanoparticles*; Neoplasms/*diagnostic imaging; Drug Delivery Systems ; Ferrocyanides ; Humans ; Neoplasms/drug therapy

Prussian blue nanoparticles (PBNPs) have attracted increasing research interest in immunosensors, bioimaging, drug delivery, and application as therapeutic agents due to their large internal pore volume, tunable size, easy synthesis and surface modification, good thermal stability, and favorable biocompatibility. This review first outlines the effect of tumor markers using PBNPs-based immunosensors which have a sandwich-type architecture and competitive-type structure. Metal ion doped PBNPs which were used as T 1 -weight magnetic resonance and photoacoustic imaging agents to improve image quality and surface modified PBNPs which were used as drug carriers to decrease side effects via passive or active targeting to tumor sites are also summarized. Moreover, the PBNPs with high photothermal efficiency and excellent catalase-like activity were promising for photothermal therapy and O 2 self-supplied photodynamic therapy of tumors. Hence, PBNPs-based multimodal imaging-guided combinational tumor therapies (such as chemo, photothermal, and photodynamic therapies) were finally reviewed. This review aims to inspire broad interest in the rational design and application of PBNPs for detecting and treating tumors in clinical research.

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81901896 National Natural Science Foundation of China; TF2020-8 Tianjin University-Fuzhou University Independent Innovation Fund

Keywords: Prussian blue nanoparticles; drug delivery; imaging; imaging-guided therapy; immunosensors

0 (Ferrocyanides)
TLE294X33A (ferric ferrocyanide)

Date Created: 20201208 Date Completed: 20210322 Latest Revision: 20240330

20250114

PMC7730465

10.3390/s20236905

33287186