Promising Roles of Alternative Medicine and Plant-Based Nanotechnology as Remedies for Urinary Tract Infections.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Anti-Bacterial Agents/*therapeutic use ; Bacteria/*drug effects ; Complementary Therapies/*methods ; Nanotechnology/*methods ; Plant Extracts/*pharmacology ; Urinary Tract Infections/*drug therapy; Humans ; Urinary Tract Infections/microbiology

Urinary tract infections (UTIs) are considered to be the most common infections worldwide, having an incidence rate of 40-60% in women. Moreover, the prevalence of this disorder in adult women is 30 times more than in men. UTIs are usually found in many hospitals and clinical practice; as disorders, they are complicated and uncomplicated; in uncomplicated cases, there is no structural or functional abnormality in the urogenital tract. However, obstruction, retention of urine flow and use of catheters increase the complexity. There are several bacteria (e.g., E. coli , Klebsiella pneumoniae , Proteus vulgaris , etc.) successfully residing in the tract. The diagnosis must not only be accurate but rapid, so early detection is an important step in the control of UTIs caused by uropathogens. The treatment of UTIs includes appropriate antimicrobial therapy to control the infection and kill the causal microbes inside the body. A long-time usage of antibiotics has resulted in multidrug resistance causing an impediment in treatment. Thus, alternative, combinatorial medication approaches have given some hope. Available treatments considered Homeopathic, Ayurvedic, Unani, and other herbal-based drugs. There are new upcoming roles of nanoparticles in combating UTIs which needs further validation. The role of medicinal plant-based nanotechnology approaches has shown promising results. Therefore, there must be active research in phyto-based therapies of UTIs, such as Ayurvedic Biology.

Clin Infect Dis. 2003 Mar 15;36(6):775-80. (PMID: 12627362)
Clin Infect Dis. 1994 Jan;18(1):1-10; quiz 11-2. (PMID: 8054415)
Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):424-37. (PMID: 19931579)
Viruses. 2018 Dec 28;11(1):. (PMID: 30597868)
Microb Pathog. 2020 Jul;144:104172. (PMID: 32224208)
Antibiotics (Basel). 2020 Feb 13;9(2):. (PMID: 32069828)
Expert Rev Anti Infect Ther. 2019 Sep;17(9):733-740. (PMID: 31516055)
Heliyon. 2019 Dec 13;5(12):e02986. (PMID: 31886428)
Scand J Infect Dis. 1990;22(1):43-7. (PMID: 2181630)
Am J Obstet Gynecol. 1981 Jun 15;140(4):427-9. (PMID: 7018247)
Nat Rev Urol. 2012 Apr 17;9(6):305-14. (PMID: 22508462)
Indian J Pharm Sci. 2009 Mar;71(2):136-9. (PMID: 20336211)
Crit Rev Environ Sci Technol. 2015 Sep 2;45(17):1827-1879. (PMID: 26246784)
New Microbiol. 2010 Oct;33(4):329-35. (PMID: 21213591)
Can Fam Physician. 2005 Nov;51:1455-7, 1462-4. (PMID: 16353824)
Plants (Basel). 2017 Apr 10;6(2):. (PMID: 28394295)
Jpn J Infect Dis. 2006 Aug;59(4):261-3. (PMID: 16936347)
Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:212-220. (PMID: 31146992)
J Infect Dis. 2001 Mar 1;183 Suppl 1:S1-4. (PMID: 11171002)
Inflamm Bowel Dis. 2009 Feb;15(2):300-10. (PMID: 18626975)
Sci Total Environ. 2019 Oct 15;687:118-127. (PMID: 31207502)
Nutr Res. 2014 Jun;34(6):518-25. (PMID: 25026919)
Ann Emerg Med. 1984 Mar;13(3):150-4. (PMID: 6696301)
JAMA. 1986 Jun 27;255(24):3397-403. (PMID: 2423720)
FEMS Immunol Med Microbiol. 2001 Dec;32(1):37-41. (PMID: 11750220)
Cytokine. 2017 Apr;92:103-109. (PMID: 28142108)
Chem Soc Rev. 2010 May;39(5):1747-63. (PMID: 20419217)
Evid Based Complement Alternat Med. 2014;2014:760683. (PMID: 24723963)
Expert Rev Mol Diagn. 2014 Mar;14(2):225-44. (PMID: 24524681)
World J Urol. 2006 Feb;24(1):28-32. (PMID: 16389539)
J Ethnopharmacol. 2013 Jan 30;145(2):591-7. (PMID: 23211661)
Front Microbiol. 2018 Aug 07;9:1832. (PMID: 30131795)
Drugs. 2008;68(4):535-65. (PMID: 18318569)
Interdiscip Perspect Infect Dis. 2020 Feb 01;2020:8042540. (PMID: 32076437)
Fitoterapia. 2018 Sep;129:237-240. (PMID: 30031115)
Iran J Public Health. 2017 Nov;46(11):1528-1534. (PMID: 29167771)
Int J Microbiol. 2019 Feb 17;2019:4246780. (PMID: 30906323)
Antimicrob Agents Chemother. 1994 May;38(5):1176-7. (PMID: 8067759)
Clin Infect Dis. 2011 May;52(10):1212-7. (PMID: 21498386)
Anal Sci. 2010;26(3):291-6. (PMID: 20215676)
Anal Chem. 2005 Mar 15;77(6):1753-60. (PMID: 15762582)
Asian Pac J Trop Biomed. 2014 Feb;4(2):104-8. (PMID: 25182280)
Rev Saude Publica. 2004 Apr;38(2):326-8. (PMID: 15122392)
Biosensors (Basel). 2018 Apr 01;8(2):. (PMID: 29614784)
Trends Pharmacol Sci. 2011 Jun;32(6):330-6. (PMID: 21458868)
West J Med. 1998 Nov;169(5):265-8. (PMID: 9830353)
Int J Biol Macromol. 2018 Apr 1;109:803-809. (PMID: 29133089)
Antimicrob Agents Chemother. 2001 Jun;45(6):1751-60. (PMID: 11353622)
J Oral Biol Craniofac Res. 2016 May-Aug;6(2):153-9. (PMID: 27195214)
Curr Microbiol. 2011 Nov;63(5):484-90. (PMID: 21901556)
J Biomed Nanotechnol. 2009 Apr;5(2):209-14. (PMID: 20055099)
Homeopathy. 2020 May;109(2):97-106. (PMID: 31958866)
J Antimicrob Chemother. 2009 Feb;63(2):389-95. (PMID: 19042940)
Singapore Med J. 2016 Sep;57(9):485-90. (PMID: 27662890)
Indian J Urol. 2008 Apr;24(2):139-44. (PMID: 19468386)
Indian J Public Health. 2017 Apr-Jun;61(2):118-123. (PMID: 28721962)
PLoS One. 2019 Mar 15;14(3):e0213797. (PMID: 30875400)
Gac Med Mex. 2015 Mar-Apr;151(2):225-44. (PMID: 25946534)
Front Microbiol. 2016 Apr 11;7:465. (PMID: 27148173)
Homeopathy. 2018 May;107(2):150-154. (PMID: 29566404)
Bioact Mater. 2016 Nov 25;1(2):140-150. (PMID: 29744403)
Molecules. 2019 Mar 23;24(6):. (PMID: 30909573)
J Hyg (Lond). 1936 Jun;36(2):204-35. (PMID: 20475326)
Antimicrob Agents Chemother. 2001 Mar;45(3):649-59. (PMID: 11181338)
Antibiotics (Basel). 2020 Aug 13;9(8):. (PMID: 32823633)

Keywords: Ayurvedic; E. coli; UTI; Unani; alternative therapy; homeopathic; nanoparticles; nanotechnology; traditional medicine

0 (Anti-Bacterial Agents)
0 (Plant Extracts)

Date Created: 20201202 Date Completed: 20210405 Latest Revision: 20240330

20240330

PMC7731396

10.3390/molecules25235593

33260701