Using Laser-Doppler Flowmetry to Evaluate the Therapeutic Response in Dentin Hypersensitivity.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE

Original Publication: Basel : MDPI, c2004-

Dentin Desensitizing Agents*/therapeutic use ; Dentin Sensitivity*/diagnostic imaging ; Dentin Sensitivity*/drug therapy ; Laser-Doppler Flowmetry*; Humans ; Reproducibility of Results ; Single-Blind Method

Dentin hypersensitivity (DH) is a common medical condition with underreported prevalence and it is difficult to quantify. This study aimed to investigate whether assessing dental pulp vascular micro-dynamics by laser-Doppler flowmetry (LDF) would be functional for therapeutic evaluation, in contrast to a verbal rating scale (VRS). A split-mouth single-blind randomized study was conducted on seven patients and a total of 36 teeth. Two DH therapeutic methods were employed: (i) fluoride gel; (ii) Nd:YAG radiation combined with fluoride gel. For each tooth, five consecutive LDF determinations of pulp blood flow were made (before and immediately after desensitizing treatment, then after 24 h, 7 days, and 1 month), and the VRS was applied each time. Spearman's correlation was applied for concurrent validation. Two-way (treatment and patient) repeated measures ANOVA full factorial was applied, followed by Tukey's post-hoc comparisons and Pillai's trace multivariate statistic. While VRS scores had moderate reliability, LDF could objectively estimate treatment effects. Based on partial eta-squared values, treatment and patient characteristics were estimated to explain about 84% and 50% of the variability, respectively. In conclusion, LDF is an objective technique that can quantitatively assess DH evolution, and it is effective in reliably monitoring oral health therapeutic interventions.

J Clin Dent. 2009;20(1):1-9. (PMID: 19489186)
J Pain Res. 2018 Apr 26;11:851-856. (PMID: 29731662)
Acta Odontol Scand. 2013 May-Jul;71(3-4):994-9. (PMID: 23140517)
Quintessence Int. 2013 Oct;44(9):709-23. (PMID: 23878846)
Gen Dent. 2016 Nov-Dec;64(6):66-70. (PMID: 27814258)
Int Endod J. 2017 Feb;50(2):135-142. (PMID: 26789282)
Lasers Med Sci. 2015 Feb;30(2):823-9. (PMID: 24197517)
Int J Dent. 2012;2012:858950. (PMID: 22792109)
J Oral Biol Craniofac Res. 2018 Jan-Apr;8(1):58-67. (PMID: 29556466)
J Contemp Dent Pract. 2005 May 15;6(2):107-17. (PMID: 15915210)
J Can Dent Assoc. 2003 Apr;69(4):221-6. (PMID: 12662460)
J Nurs Scholarsh. 2009;41(3):241-9. (PMID: 19723272)
J Pain Symptom Manage. 2011 Jun;41(6):1073-93. (PMID: 21621130)
J Endod. 2019 May;45(5):490-499. (PMID: 30878165)
Oper Dent. 2015 Nov-Dec;40(6):614-21. (PMID: 26151563)
Caries Res. 1967;1(4):310-7. (PMID: 5241870)
Dent Traumatol. 2018 Oct;34(5):311-319. (PMID: 29953720)
Int J Nanomedicine. 2015 Oct 08;10:6371-94. (PMID: 26504385)
J Am Dent Assoc. 2010 Sep;141(9):1097-105. (PMID: 20807910)
Pak J Med Sci. 2018 Jul-Aug;34(4):787-793. (PMID: 30190729)
J Periodontol. 2005 Jul;76(7):1140-7. (PMID: 16018757)
J Oral Rehabil. 2009 Jan;36(1):45-51. (PMID: 19207369)
Aust Dent J. 2006 Sep;51(3):212-8; quiz 276. (PMID: 17037886)
Rehabil Nurs. 2005 Mar-Apr;30(2):55-61. (PMID: 15789697)
Braz Oral Res. 2015;29:45. (PMID: 25760065)
J Am Dent Assoc. 1963 Mar;66:366-70. (PMID: 14014982)
Am J Emerg Med. 2018 Apr;36(4):707-714. (PMID: 29321111)
J Am Dent Assoc. 2006 Jul;137(7):990-8; quiz 1028-9. (PMID: 16803826)
J Dent. 2007 May;35(5):398-402. (PMID: 17222958)
Pain Med. 2007 Apr;8(3):223-34. (PMID: 17371409)
Photomed Laser Surg. 2009 Dec;27(6):843-8. (PMID: 19281413)
Dent Traumatol. 2014 Jun;30(3):188-92. (PMID: 24112609)
Stat Med. 2009 Dec 10;28(28):3470-82. (PMID: 19536744)
Photomed Laser Surg. 2014 Oct;32(10):540-5. (PMID: 25238037)
J Evid Based Dent Pract. 2019 Jun;19(2):115-130. (PMID: 31326044)
J Oral Rehabil. 2011 May;38(5):340-7. (PMID: 20868433)
J Clin Periodontol. 2015 Apr;42 Suppl 16:S256-302. (PMID: 25495777)
Photomed Laser Surg. 2013 Mar;31(3):132-8. (PMID: 23421629)
Photomed Laser Surg. 2009 Oct;27(5):807-12. (PMID: 19715434)

Keywords: dentin hypersensitivity; laser Doppler flowmetry; microcirculation; outcome assessment; therapeutic research

0 (Dentin Desensitizing Agents)

Date Created: 20201201 Date Completed: 20210211 Latest Revision: 20210211

20221213

PMC7731012

10.3390/ijerph17238787

33256192