Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Antineoplastic Agents/*therapeutic use ; Chronic Disease/*drug therapy ; Neoplasms/*drug therapy; Animals ; Antineoplastic Agents/pharmacology ; Cellular Senescence ; Chronic Disease/mortality ; Clinical Trials as Topic ; Global Health ; Humans ; Neoplasms/mortality ; Signal Transduction/drug effects

The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently needed problem of social relevance. During aging, many biological processes are altered, which globally induce the dysfunction of the whole organism. Cell senescence is one of the causes of this modification. Nowadays, several drugs approved for anticancer therapy have been repurposed to treat senescence, and others are under scrutiny in vitro and in vivo to establish their senomorphic or senolytic properties. In some cases, this research led to a significant increase in cell survival or to a prolonged lifespan in animal models, at least. Senomorphics can act to interfere with a specific pathway in order to restore the appropriate cellular function, preserve viability, and to prolong the lifespan. On the other hand, senolytics induce apoptosis in senescent cells allowing the remaining non-senescent population to preserve or restore tissue function. A large number of research articles and reviews recently addressed this topic. Herein, we would like to focus attention on those chemical agents with senomorphic or senolytic properties that perspectively, according to literature, suggest a potential application as senotherapeutics for chronic diseases.

Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R501-9. (PMID: 18077512)
J Drug Target. 2018 Sep;26(8):670-675. (PMID: 29378454)
Nat Commun. 2019 Oct 21;10(1):4731. (PMID: 31636264)
Nature. 2006 Jun 22;441(7096):1011-4. (PMID: 16791200)
J Heart Lung Transplant. 2007 Feb;26(2):174-80. (PMID: 17258152)
Blood Adv. 2020 Jun 23;4(12):2762-2767. (PMID: 32569380)
Nature. 2012 Jan 18;481(7381):287-94. (PMID: 22258607)
Int J Mol Sci. 2019 Apr 14;20(8):. (PMID: 31013989)
Cell Stem Cell. 2019 Oct 3;25(4):514-530.e8. (PMID: 31543366)
Cell Rep. 2015 Sep 1;12(9):1391-9. (PMID: 26299964)
J Cell Biol. 2011 Feb 21;192(4):547-56. (PMID: 21321098)
Oxid Med Cell Longev. 2017;2017:1092015. (PMID: 29138670)
Cell Death Dis. 2010;1:e10. (PMID: 21364612)
Front Cell Dev Biol. 2020 Jan 22;7:367. (PMID: 32039197)
Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838)
J Vet Cardiol. 2018 Oct;20(5):307-318. (PMID: 30119945)
EBioMedicine. 2017 Jul;21:21-28. (PMID: 28416161)
Br J Cancer. 2020 May;122(10):1544-1551. (PMID: 32203216)
Cell Metab. 2019 Jul 2;30(1):129-142.e4. (PMID: 31155496)
Hum Gene Ther. 2007 Feb;18(2):106-17. (PMID: 17328681)
Cell. 1997 Mar 7;88(5):593-602. (PMID: 9054499)
Aging Cell. 2014 Apr;13(2):273-82. (PMID: 24245565)
Cell. 2008 Feb 22;132(4):681-96. (PMID: 18295583)
Epigenetics. 2015;10(2):142-52. (PMID: 25565250)
Biomed Pharmacother. 2019 Jan;109:1462-1477. (PMID: 30551398)
BMC Pulm Med. 2017 Dec 02;17(1):163. (PMID: 29197377)
Biochemistry (Mosc). 2008 Dec;73(12):1300-16. (PMID: 19120016)
Pharmacology. 2003 Jun;68(2):81-8. (PMID: 12711835)
Ageing Res Rev. 2011 Apr;10(2):205-15. (PMID: 20152936)
Circ Heart Fail. 2016 Jan;9(1):e002081. (PMID: 26721911)
Aging Cell. 2019 Jun;18(3):e12950. (PMID: 30907060)
Nat Commun. 2017 Sep 4;8(1):422. (PMID: 28871086)
Brain Res. 2005 Mar 21;1038(2):216-22. (PMID: 15757637)
J Neurosurg. 2017 Dec;127(6):1219-1230. (PMID: 28059653)
Life Sci. 2020 May 15;249:117532. (PMID: 32151689)
PLoS One. 2015 Dec 09;10(12):e0144506. (PMID: 26649750)
J Physiol Sci. 2018 Sep;68(5):681-688. (PMID: 29230719)
Nature. 2001 Sep 27;413(6854):432-5. (PMID: 11574891)
Sci Rep. 2015 Dec 14;5:17895. (PMID: 26658759)
FASEB J. 2009 Sep;23(9):2810-9. (PMID: 19376817)
Aging Cell. 2014 Jun;13(3):468-77. (PMID: 24341993)
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9562-6. (PMID: 9689120)
Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L33-9. (PMID: 16905640)
EBioMedicine. 2019 Sep;47:446-456. (PMID: 31542391)
Nat Genet. 1997 Sep;17(1):100-3. (PMID: 9288107)
Cell Metab. 2006 Mar;3(3):153-65. (PMID: 16517403)
Curr Biol. 2006 Feb 7;16(3):296-300. (PMID: 16461283)
Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H124-34. (PMID: 22037186)
Aging (Albany NY). 2019 May 19;11(10):3117-3137. (PMID: 31105084)
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. (PMID: 16461887)
Aging (Albany NY). 2018 Nov 14;10(11):3294-3307. (PMID: 30428454)
Nat Commun. 2020 Aug 27;11(1):4289. (PMID: 32855397)
J Radiat Res. 2010;51(4):473-9. (PMID: 20679743)
Redox Biol. 2020 Jan;28:101337. (PMID: 31622846)
Aging Cell. 2016 Oct;15(5):973-7. (PMID: 26864908)
EBioMedicine. 2019 Feb;40:554-563. (PMID: 30616998)
Clin Orthop Relat Res. 2004 Oct;(427 Suppl):S27-36. (PMID: 15480070)
Front Oncol. 2018 Dec 11;8:614. (PMID: 30619754)
Int J Mol Sci. 2020 Sep 09;21(18):. (PMID: 32916794)
Aging Cell. 2015 Aug;14(4):644-58. (PMID: 25754370)
PLoS Biol. 2008 Dec 2;6(12):2853-68. (PMID: 19053174)
Science. 1995 Jun 23;268(5218):1749-53. (PMID: 7792600)
Nat Med. 2018 Aug;24(8):1246-1256. (PMID: 29988130)
Aging Cell. 2018 Dec;17(6):e12840. (PMID: 30126037)
Am J Pathol. 1989 May;134(5):1019-25. (PMID: 2719072)
Trends Cell Biol. 2012 Jan;22(1):42-9. (PMID: 22177962)
Am J Physiol Regul Integr Comp Physiol. 2002 Apr;282(4):R985-92. (PMID: 11893601)
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1876-81. (PMID: 11854488)
Ageing Res Rev. 2020 Sep;62:101097. (PMID: 32540391)
Aging (Albany NY). 2017 Mar 8;9(3):955-963. (PMID: 28273655)
PLoS One. 2008 Jun 04;3(6):e2264. (PMID: 18523577)
Nat Med. 2016 Jan;22(1):78-83. (PMID: 26657143)
Curr Med Chem. 2016;23(41):4639-4680. (PMID: 27781945)
Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86. (PMID: 23104557)
Aging (Albany NY). 2019 Jan 28;11(2):771-782. (PMID: 30694217)
Cell Metab. 2017 Dec 5;26(6):884-896.e5. (PMID: 29107506)
EMBO J. 2016 Apr 1;35(7):724-42. (PMID: 26848154)
Haematologica. 2012 Mar;97(3):353-9. (PMID: 22058220)
Ann Transl Med. 2020 Mar;8(6):364. (PMID: 32355808)
Lab Invest. 2017 Dec;97(12):1453-1470. (PMID: 28892098)
Sci Rep. 2019 Mar 14;9(1):4445. (PMID: 30872769)
Mitochondrion. 2020 Sep;54:72-84. (PMID: 32738358)
Cell. 2015 Jan 29;160(3):477-88. (PMID: 25619689)
Nat Commun. 2017 Feb 23;8:14532. (PMID: 28230051)
Bioinformatics. 2009 Apr 1;25(7):875-81. (PMID: 19189975)
Matrix Biol. 2018 Jan;65:30-44. (PMID: 28634008)
Proc Natl Acad Sci U S A. 1986 Jun;83(11):4044-8. (PMID: 2424016)
Aging (Albany NY). 2009 Dec 23;1(12):961-70. (PMID: 20157579)
J Clin Invest. 1991 May;87(5):1828-34. (PMID: 2022748)
Vitam Horm. 2016;101:119-50. (PMID: 27125740)
Geroscience. 2020 Apr;42(2):409-428. (PMID: 31960269)
Cell Metab. 2011 Nov 2;14(5):612-22. (PMID: 22055504)
Metab Brain Dis. 2017 Feb;32(1):57-68. (PMID: 27488110)
Biofactors. 2013 Jan-Feb;39(1):133-40. (PMID: 23325575)
Nat Neurosci. 2019 May;22(5):719-728. (PMID: 30936558)
Free Radic Biol Med. 1998 Jan 15;24(2):298-304. (PMID: 9433905)
Redox Biol. 2015;4:355-62. (PMID: 25677087)
Clin Cancer Res. 2011 Mar 15;17(6):1561-70. (PMID: 21278242)
Nucleic Acids Res. 2015 Mar 11;43(5):2560-74. (PMID: 25712104)
Drug Des Devel Ther. 2019 May 27;13:1843-1853. (PMID: 31213772)
Cell Metab. 2019 May 7;29(5):1045-1060.e10. (PMID: 30799288)
J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. (PMID: 28869295)
Nat Cell Biol. 2009 Nov;11(11):1305-14. (PMID: 19801973)
Carcinogenesis. 2019 Apr 29;40(2):324-334. (PMID: 30698677)
Toxicol Appl Pharmacol. 2019 Feb 1;364:29-44. (PMID: 30529165)
PLoS One. 2015 Mar 19;10(3):e0118393. (PMID: 25790328)
Antioxidants (Basel). 2019 May 08;8(5):. (PMID: 31071926)
Br J Dermatol. 2003 Nov;149(5):951-9. (PMID: 14632798)
Biomedicines. 2020 Jun 18;8(6):. (PMID: 32570831)
Biomed Res Int. 2016;2016:8569684. (PMID: 27999817)
Aging Cell. 2012 Aug;11(4):569-78. (PMID: 22404905)
Nat Rev Mol Cell Biol. 2010 Jul;11(7):515-28. (PMID: 20531426)
Science. 2017 Oct 6;358(6359):45-46. (PMID: 28983039)
Osteoarthritis Cartilage. 2010 Mar;18(3):424-32. (PMID: 19822235)
FASEB J. 2014 Jul;28(7):3225-37. (PMID: 24687991)
Biochem Pharmacol. 2005 Dec 5;70(12):1796-806. (PMID: 16216225)
Nanomedicine. 2019 Feb;16:236-249. (PMID: 30639669)
J Clin Invest. 2011 Jul;121(7):2833-44. (PMID: 21670498)
Mol Cells. 2019 Mar 31;42(3):210-217. (PMID: 30726661)
Respir Res. 2016 Mar 14;17:28. (PMID: 26975422)
Nature. 2016 Feb 11;530(7589):184-9. (PMID: 26840489)
Aging (Albany NY). 2020 Jan 18;12(3):2711-2722. (PMID: 31955151)
Aging Cell. 2018 Oct;17(5):e12827. (PMID: 30058137)
Aging Cell. 2019 Jun;18(3):e12945. (PMID: 30920115)
J Invest Dermatol. 1979 Jul;73(1):8-14. (PMID: 448179)
Int J Mol Sci. 2018 Oct 09;19(10):. (PMID: 30304806)

Ricerca Corrente and 5 × 1000 Italian Ministry of Health

Keywords: aging; apoptosis; chronic diseases; clinical trials; senescence; senolytics; senomorphics; senotherapeutics

0 (Antineoplastic Agents)

Date Created: 20201030 Date Completed: 20210303 Latest Revision: 20210303

20240628

PMC7663758

10.3390/ijms21217984

33121118