Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Metabolomics* ; Vibration*; Magnetic Resonance Spectroscopy/*methods ; Spectroscopy, Fourier Transform Infrared/*methods; Metabolome/genetics ; Spectrophotometry, Infrared ; Spectrum Analysis, Raman/methods

Vibrational spectroscopy (mid-infrared (IR) and Raman) and its fingerprinting capabilities offer rapid, high-throughput, and non-destructive analysis of a wide range of sample types producing a characteristic chemical "fingerprint" with a unique signature profile. Nuclear magnetic resonance (NMR) spectroscopy and an array of mass spectrometry (MS) techniques provide selectivity and specificity for screening metabolites, but demand costly instrumentation, complex sample pretreatment, are labor-intensive, require well-trained technicians to operate the instrumentation, and are less amenable for implementation in clinics. The potential for vibration spectroscopy techniques to be brought to the bedside gives hope for huge cost savings and potential revolutionary advances in diagnostics in the clinic. We discuss the utilization of current vibrational spectroscopy methodologies on biologic samples as an avenue towards rapid cost saving diagnostics.

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2019 - Kevin V. Hackshaw Columbus Medical Research Foundation

Keywords: Raman spectroscopy; biofluid; biomarker; diagnostics; fingerprinting; infrared spectroscopy; metabolites; spectroscopy; vibrational spectroscopy

Date Created: 20201020 Date Completed: 20210326 Latest Revision: 20240330

20240330

PMC7587585

10.3390/molecules25204725

33076318