Cytosolic Sensors for Pathogenic Viral and Bacterial Nucleic Acids in Fish.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Biosensing Techniques*; Bacteria/*isolation & purification ; Nucleic Acids/*isolation & purification ; Viruses/*isolation & purification; Animals ; Bacteria/pathogenicity ; Cytosol/microbiology ; Cytosol/virology ; DNA Viruses/genetics ; DNA Viruses/isolation & purification ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; DNA-Binding Proteins/chemistry ; Fishes/genetics ; Fishes/microbiology ; Fishes/virology ; Nucleic Acids/genetics ; RNA Recognition Motif Proteins/chemistry ; RNA, Bacterial/genetics ; RNA, Bacterial/isolation & purification ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Viruses/pathogenicity

Recognition of the non-self signature of invading pathogens is a crucial step for the initiation of the innate immune mechanisms of the host. The host response to viral and bacterial infection involves sets of pattern recognition receptors (PRRs), which bind evolutionarily conserved pathogen structures, known as pathogen-associated molecular patterns (PAMPs). Recent advances in the identification of different types of PRRs in teleost fish revealed a number of cytosolic sensors for recognition of viral and bacterial nucleic acids. These are DExD/H-box RNA helicases including a group of well-characterized retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) and non-RLR DExD/H-box RNA helicases (e.g., DDX1, DDX3, DHX9, DDX21, DHX36 and DDX41) both involved in recognition of viral RNAs. Another group of PRRs includes cytosolic DNA sensors (CDSs), such as cGAS and LSm14A involved in recognition of viral and intracellular bacterial dsDNAs. Moreover, dsRNA-sensing protein kinase R (PKR), which has a role in antiviral immune responses in higher vertebrates, has been identified in fish. Additionally, fish possess a novel PKR-like protein kinase containing Z-DNA binding domain, known as PKZ. Here, we review the current knowledge concerning cytosolic sensors for recognition of viral and bacterial nucleic acids in teleosts.

Curr Opin Immunol. 2008 Feb;20(1):17-22. (PMID: 18272355)
Curr Opin Virol. 2011 Dec;1(6):519-25. (PMID: 22328912)
Fish Shellfish Immunol. 2016 Aug;55:173-85. (PMID: 27235368)
Exp Cell Res. 1998 Dec 15;245(2):272-81. (PMID: 9851867)
Hepatology. 2018 Nov;68(5):1695-1709. (PMID: 29679386)
Fish Shellfish Immunol. 2018 Jan;72:14-22. (PMID: 29074131)
Biochem Pharmacol. 2010 Feb 1;79(3):297-306. (PMID: 19782656)
J Intern Med. 2007 Jun;261(6):511-28. (PMID: 17547708)
Fish Shellfish Immunol. 2015 Mar;43(1):13-24. (PMID: 25524497)
Dev Comp Immunol. 2015 Mar;49(1):138-48. (PMID: 25450904)
J Fish Dis. 2017 Nov;40(11):1529-1544. (PMID: 28429853)
EMBO J. 2008 Aug 6;27(15):2135-46. (PMID: 18583960)
Fish Shellfish Immunol. 2011 Mar;30(3):936-43. (PMID: 21288492)
J Virol. 2017 Feb 28;91(6):. (PMID: 28077645)
Dev Comp Immunol. 2016 Aug;61:161-8. (PMID: 27039216)
Fish Shellfish Immunol. 2019 Mar;86:1114-1122. (PMID: 30594581)
Immunology. 2014 Feb;141(2):192-202. (PMID: 24116956)
Front Immunol. 2019 Apr 26;10:906. (PMID: 31080451)
Sci Immunol. 2017 May 19;2(11):. (PMID: 28763795)
Cell. 2018 Jul 12;174(2):300-311.e11. (PMID: 30007416)
Fish Shellfish Immunol. 2014 Oct;40(2):399-406. (PMID: 25107693)
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1602-7. (PMID: 15659550)
Cytokine. 2015 Aug;74(2):198-206. (PMID: 25794939)
J Immunol. 2007 May 15;178(10):6444-55. (PMID: 17475874)
Int J Mol Sci. 2015 Mar 18;16(3):6235-50. (PMID: 25794284)
Dis Aquat Organ. 2009 Jun 10;85(2):105-13. (PMID: 19694170)
Biochim Biophys Acta. 2013 Aug;1829(8):854-65. (PMID: 23567047)
Nature. 2013 Jun 20;498(7454):332-7. (PMID: 23722159)
Front Immunol. 2020 Apr 28;11:615. (PMID: 32411126)
J Immunol. 2016 Jun 15;196(12):5101-11. (PMID: 27183626)
Fish Shellfish Immunol. 2004 Oct;17(4):353-66. (PMID: 15312662)
J Fish Biol. 2015 Jan;86(1):74-91. (PMID: 25359511)
Jpn J Vet Res. 2004 Feb;51(3-4):123-33. (PMID: 15070037)
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1465-70. (PMID: 11171974)
Fish Shellfish Immunol. 2019 Nov;94:373-380. (PMID: 31533080)
Science. 1999 Jun 11;284(5421):1841-5. (PMID: 10364558)
Fish Shellfish Immunol. 2010 Aug;29(2):349-55. (PMID: 20420913)
J Virol. 2012 Mar;86(6):2900-10. (PMID: 22258243)
RNA Biol. 2013 Jan;10(1):121-32. (PMID: 23353573)
Virol J. 2011 Aug 10;8:396. (PMID: 21827718)
Eur J Immunol. 2010 Apr;40(4):940-8. (PMID: 20127681)
Dev Comp Immunol. 2011 May;35(5):554-62. (PMID: 21185857)
Trends Immunol. 2002 Nov;23(11):509-12. (PMID: 12401394)
Microbiol Mol Biol Rev. 2006 Dec;70(4):1032-60. (PMID: 17158706)
Oncotarget. 2016 Jul 5;7(27):42716-42739. (PMID: 27034008)
Fish Shellfish Immunol. 2019 Oct;93:1056-1066. (PMID: 31340170)
Dev Comp Immunol. 2019 Oct;99:103402. (PMID: 31141705)
J Immunol. 2008 Apr 15;180(8):5373-83. (PMID: 18390719)
Dev Comp Immunol. 2016 Feb;55:188-93. (PMID: 26493015)
J Immunol. 2018 Jan 15;200(2):768-774. (PMID: 29212905)
J Exp Med. 2018 May 7;215(5):1287-1299. (PMID: 29622565)
Fish Shellfish Immunol. 2015 Apr;43(2):460-8. (PMID: 25655327)
Comp Biochem Physiol Part D Genomics Proteomics. 2017 Jun;22:109-119. (PMID: 28288365)
J Immunol. 2010 Dec 15;185(12):7507-17. (PMID: 21098234)
Fish Shellfish Immunol. 2016 Aug;55:535-49. (PMID: 27346150)
J Virol. 2009 Aug;83(16):7815-27. (PMID: 19474100)
PLoS Pathog. 2019 Dec 26;15(12):e1008239. (PMID: 31877196)
Immunity. 2012 Jun 29;36(6):959-73. (PMID: 22705106)
Fish Shellfish Immunol. 2013 Dec;35(6):1874-81. (PMID: 24084043)
Front Immunol. 2019 Sep 18;10:2202. (PMID: 31620127)
Gene. 2015 Feb 25;557(2):172-81. (PMID: 25523097)
Curr Opin Immunol. 1997 Feb;9(1):4-9. (PMID: 9039775)
J Virol. 2011 Dec;85(23):12769-80. (PMID: 21937641)
J Virol. 2012 Jan;86(2):705-17. (PMID: 22072756)
Cell. 2005 Sep 9;122(5):669-82. (PMID: 16125763)
Fish Shellfish Immunol. 2019 Mar;86:1058-1063. (PMID: 30593899)
Immunity. 2013 May 23;38(5):870-80. (PMID: 23706668)
PLoS Pathog. 2016 Apr 08;12(4):e1005546. (PMID: 27058035)
Fish Shellfish Immunol. 2010 Dec;29(6):979-86. (PMID: 20800685)
Dev Comp Immunol. 2018 Jan;78:71-82. (PMID: 28919361)
Fish Shellfish Immunol. 2020 Jun;101:1-8. (PMID: 32201348)
J Mol Med (Berl). 2005 Mar;83(3):180-92. (PMID: 15635478)
Fish Shellfish Immunol. 2016 Nov;58:193-202. (PMID: 27637730)
J Immunol. 2011 Sep 1;187(5):2531-9. (PMID: 21795596)
Fish Shellfish Immunol. 2016 Aug;55:249-56. (PMID: 27238428)
Genet Sel Evol. 2006 Sep-Oct;38(5):551-63. (PMID: 16954046)
EMBO J. 2008 Aug 6;27(15):2147-57. (PMID: 18636090)
Fish Shellfish Immunol. 2015 Jun;44(2):576-83. (PMID: 25776036)
Dev Comp Immunol. 2017 Nov;76:93-104. (PMID: 28559111)
Fish Shellfish Immunol. 2015 Apr;43(2):427-35. (PMID: 25634257)
Front Immunol. 2017 Mar 27;8:352. (PMID: 28396670)
Curr Opin Immunol. 2015 Feb;32:48-53. (PMID: 25594890)
Fish Shellfish Immunol. 2019 Nov;94:485-496. (PMID: 31494278)
Dev Comp Immunol. 2012 Oct;38(2):193-202. (PMID: 22721905)
J Virol. 2011 Aug;85(16):8403-12. (PMID: 21680521)
J Immunol. 2005 Sep 1;175(5):2851-8. (PMID: 16116171)
Science. 2013 Aug 23;341(6148):903-6. (PMID: 23929945)
Front Immunol. 2018 Jun 14;9:1297. (PMID: 29963044)
Fish Shellfish Immunol. 2013 Dec;35(6):1689-702. (PMID: 23462146)
Fish Shellfish Immunol. 2017 Mar;62:265-275. (PMID: 28119144)
Immunity. 2013 Jul 25;39(1):123-35. (PMID: 23871209)
Dev Comp Immunol. 2011 Nov;35(11):1103-15. (PMID: 21527281)
Mol Cell Biol. 2011 Sep;31(18):3802-19. (PMID: 21791617)
Dev Comp Immunol. 2018 Feb;79:175-185. (PMID: 29100916)
J Virol. 2017 Jun 26;91(14):. (PMID: 28446670)
Fish Shellfish Immunol. 2008 Jul;25(1-2):106-13. (PMID: 18448359)
Fish Shellfish Immunol. 2018 May;76:183-186. (PMID: 29510252)
Dev Comp Immunol. 2012 Jul;37(3-4):381-9. (PMID: 22387588)
Dev Comp Immunol. 2010 May;34(5):546-52. (PMID: 20045026)
Science. 2002 Apr 12;296(5566):301-5. (PMID: 11951032)
Nature. 2001 Apr 26;410(6832):1099-103. (PMID: 11323673)
Hepatology. 2016 Sep;64(3):746-59. (PMID: 27312012)
Infect Immun. 2018 Feb 20;86(3):. (PMID: 29263110)
Rev Med Virol. 2010 Jan;20(1):4-22. (PMID: 20041442)
Fish Shellfish Immunol. 2020 Sep;104:62-73. (PMID: 32526283)
Dev Comp Immunol. 2014 Sep;46(1):35-52. (PMID: 24560981)
Nat Immunol. 2011 Sep 04;12(10):959-65. (PMID: 21892174)
Fish Shellfish Immunol. 2012 Jan;32(1):79-88. (PMID: 22056498)
Nucleic Acids Res. 2006;34(15):4168-80. (PMID: 16936318)
Cytokine Growth Factor Rev. 2013 Apr;24(2):91-104. (PMID: 23102645)
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2562-7. (PMID: 18256184)
EMBO Rep. 2017 Oct;18(10):1707-1715. (PMID: 28801534)
Dev Comp Immunol. 2017 Nov;76:255-261. (PMID: 28666650)
Vet Immunol Immunopathol. 2010 Feb 15;133(2-4):290-5. (PMID: 19729206)
Dev Comp Immunol. 2020 Mar;104:103571. (PMID: 31837379)
RNA. 2006 Apr;12(4):547-54. (PMID: 16484376)
Fish Shellfish Immunol. 2020 Apr;99:386-391. (PMID: 32081808)
Curr Opin Immunol. 2010 Feb;22(1):41-7. (PMID: 20061127)
Front Genet. 2014 Dec 05;5:423. (PMID: 25538732)
Dev Comp Immunol. 2015 Aug;51(2):298-304. (PMID: 25634485)
J Biol Chem. 1999 Jun 18;274(25):17406-9. (PMID: 10364168)
J Immunol. 2018 Jan 15;200(2):688-703. (PMID: 29203516)
J Biol Chem. 2006 Dec 29;281(52):40096-106. (PMID: 17074753)
Fish Shellfish Immunol. 2011 Jan;30(1):317-23. (PMID: 21078397)
Cell. 2014 Aug 14;158(4):764-777. (PMID: 25126784)
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15181-6. (PMID: 20696886)
Curr Opin Struct Biol. 2019 Dec;59:178-187. (PMID: 31593902)
Science. 2019 Mar 8;363(6431):. (PMID: 30846571)
J Virol. 2019 May 29;93(12):. (PMID: 30918080)
Fish Shellfish Immunol. 2015 Aug;45(2):574-82. (PMID: 25989622)
Dev Comp Immunol. 2015 Mar;49(1):19-30. (PMID: 25445907)
Fish Shellfish Immunol. 2010 Apr;28(4):712-8. (PMID: 20109556)
PLoS One. 2012;7(12):e51522. (PMID: 23251565)
Nat Struct Biol. 2001 Sep;8(9):761-5. (PMID: 11524677)
Int J Mol Sci. 2017 Jul 15;18(7):. (PMID: 28714877)
Cell. 2006 Feb 24;124(4):783-801. (PMID: 16497588)
Immunol Rev. 2011 Sep;243(1):61-73. (PMID: 21884167)
Mol Cell. 2008 Feb 29;29(4):428-40. (PMID: 18242112)
Cell. 1990 Jul 27;62(2):379-90. (PMID: 1695551)
J Immunol. 2017 May 1;198(9):3627-3636. (PMID: 28363908)
EMBO Rep. 2018 Jun;19(6):. (PMID: 29661858)
Science. 2013 Feb 15;339(6121):786-91. (PMID: 23258413)
J Virol. 2015 Aug;89(15):7696-706. (PMID: 25972544)
Vet Immunol Immunopathol. 2010 Apr 15;134(3-4):139-50. (PMID: 19850357)
J Innate Immun. 2018;10(3):239-252. (PMID: 29791904)
Fish Shellfish Immunol. 2017 Jul;66:360-371. (PMID: 28526571)
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2281-6. (PMID: 11854525)
J Fish Biol. 2020 Jun;96(6):1399-1410. (PMID: 32133636)
Fish Shellfish Immunol. 2017 Dec;71:95-104. (PMID: 28964860)
Nat Immunol. 2009 Oct;10(10):1073-80. (PMID: 19701189)
Fish Shellfish Immunol. 2017 Apr;63:261-269. (PMID: 28232279)
Fish Shellfish Immunol. 2016 Oct;57:127-135. (PMID: 27539705)
Dev Comp Immunol. 2015 Jan;48(1):95-101. (PMID: 25265425)
Dev Comp Immunol. 2011 Dec;35(12):1263-72. (PMID: 21414346)
Fish Shellfish Immunol. 2011 Dec;31(6):1173-8. (PMID: 22008285)
BMC Biol. 2008 Mar 03;6:12. (PMID: 18312693)
Front Immunol. 2017 Feb 24;8:189. (PMID: 28286505)
Fish Shellfish Immunol. 2013 Mar;34(3):909-19. (PMID: 23333439)
J Virol. 2018 Jul 17;92(15):. (PMID: 29793952)
Cell Rep. 2013 May 30;3(5):1362-8. (PMID: 23707061)
Immunity. 2011 Jun 24;34(6):866-78. (PMID: 21703541)
Sci Signal. 2014 Apr 29;7(323):ra40. (PMID: 24782566)
Vet Immunol Immunopathol. 2013 Sep 1;155(1-2):110-6. (PMID: 23871214)
Fish Shellfish Immunol. 2018 Nov;82:101-114. (PMID: 30099139)
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7. (PMID: 20080593)
Int J Mol Sci. 2019 Dec 22;21(1):. (PMID: 31877895)
J Fish Biol. 2016 Jun;88(6):2188-202. (PMID: 27108774)
Sci Rep. 2019 Jul 8;9(1):9825. (PMID: 31285443)
PLoS One. 2014 Jun 11;9(6):e99610. (PMID: 24918927)
Viruses. 2016 Apr 21;8(4):114. (PMID: 27110808)
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8421-6. (PMID: 9237992)
Fish Shellfish Immunol. 2011 Apr-May;30(4-5):1159-69. (PMID: 21385615)
Front Immunol. 2019 Jul 17;10:1586. (PMID: 31379819)
Dev Comp Immunol. 2018 Sep;86:52-64. (PMID: 29727627)
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7747-52. (PMID: 24821782)
J Immunol. 2011 Nov 1;187(9):4501-8. (PMID: 21957149)
PLoS One. 2014 May 12;9(5):e97471. (PMID: 24820969)
Elife. 2014 Feb 18;3:e01535. (PMID: 24550253)
J Virol. 2008 Jul;82(14):6889-901. (PMID: 18448522)
J Virol. 2006 Dec;80(24):12332-42. (PMID: 17020950)
FEBS J. 2008 Jan;275(1):184-97. (PMID: 18076653)
J Vet Med Sci. 2019 Oct 24;81(10):1468-1474. (PMID: 31534060)
Fish Shellfish Immunol. 2015 Nov;47(1):214-20. (PMID: 26363231)
Fish Shellfish Immunol. 2016 Jul;54:188-96. (PMID: 27050314)
Immunogenetics. 2013 Jul;65(7):511-30. (PMID: 23558557)
Dev Comp Immunol. 2009 Nov;33(11):1196-204. (PMID: 19576240)
Fish Shellfish Immunol. 2019 Jun;89:18-26. (PMID: 30905838)
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11770-5. (PMID: 22745163)
Nat Microbiol. 2019 Apr;4(4):701-713. (PMID: 30804548)
Anticancer Res. 2004 Nov-Dec;24(6):3951-3. (PMID: 15736437)
Front Immunol. 2020 Mar 31;11:585. (PMID: 32296447)
Dev Comp Immunol. 2015 Nov;53(1):23-32. (PMID: 26111995)
G3 (Bethesda). 2015 Jun 24;5(8):1765-73. (PMID: 26109358)
Fish Shellfish Immunol. 2016 Sep;56:358-366. (PMID: 27436518)
RNA Biol. 2010 Nov-Dec;7(6):775-87. (PMID: 21173576)
Fish Shellfish Immunol. 2019 Nov;94:871-879. (PMID: 31597087)
Gene. 2006 Feb 15;367:17-37. (PMID: 16337753)
Immunity. 2011 May 27;34(5):680-92. (PMID: 21616437)
Mol Cell Biochem. 2015 Jan;399(1-2):247-56. (PMID: 25408553)
J Virol. 2002 Sep;76(17):8729-36. (PMID: 12163593)
PLoS One. 2014 Nov 13;9(11):e112918. (PMID: 25393122)
EMBO J. 2016 Feb 15;35(4):429-42. (PMID: 26746851)
Immunology. 2017 May;151(1):16-25. (PMID: 28109007)
Fish Shellfish Immunol. 2014 Dec;41(2):222-30. (PMID: 25219369)
PLoS One. 2012;7(7):e42182. (PMID: 22860079)
Vet Res. 2015 Mar 06;46:26. (PMID: 25888832)
Nucleic Acids Res. 2006;34(15):4206-15. (PMID: 16935882)
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10950-5. (PMID: 27621475)
FASEB J. 2020 Jun;34(6):7786-7809. (PMID: 32285982)
Nat Immunol. 2012 Dec;13(12):1155-61. (PMID: 23142775)
J Virol. 2004 Jan;78(2):576-84. (PMID: 14694089)
Fish Shellfish Immunol. 2019 Aug;91:40-49. (PMID: 31082519)
Fish Shellfish Immunol. 2015 Oct;46(2):693-702. (PMID: 26260315)
Cell Host Microbe. 2015 Jun 10;17(6):820-8. (PMID: 26048137)
Cell Host Microbe. 2015 Jun 10;17(6):811-819. (PMID: 26048136)

UMO-2015/18/E/NZ6/00516 Narodowe Centrum Nauki; KAKENHI Grant number 17H03863 Japan Society for the Promotion of Science

Keywords: DExD/H-box RNA helicases; LSm14A; PKZ; RIG-I; RLR; cGAS

0 (DNA, Bacterial)
0 (DNA-Binding Proteins)
0 (Nucleic Acids)
0 (RNA Recognition Motif Proteins)
0 (RNA, Bacterial)
0 (RNA, Viral)

Date Created: 20201007 Date Completed: 20210226 Latest Revision: 20210226

20221213

PMC7582293

10.3390/ijms21197289

33023222