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Development, optimisation, and evaluation of nanoencapsulated diacerein emulgel for potential use in osteoarthritis.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8500513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5246 (Electronic) Linking ISSN: 02652048 NLM ISO Abbreviation: J Microencapsul Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: London [England] ; Philadelphia : Taylor & Francis, c1984-
    • الموضوع:
      Biomimetics*; Anthraquinones/*chemistry ; Chitosan/*chemistry ; Nanoparticles/*chemistry ; Osteoarthritis/*drug therapy ; Polymers/*chemistry; Administration, Oral ; Animals ; Anti-Inflammatory Agents/chemistry ; Drug Delivery Systems ; Drug Design ; Gels ; In Vitro Techniques ; Male ; Particle Size ; Rats ; Rats, Sprague-Dawley ; Skin/drug effects ; Spectroscopy, Fourier Transform Infrared ; Viscosity
    • نبذة مختصرة :
      Aim: This study aimed to utilise the proficient function of diacerein (DCR) and anti-inflammatory polymers to develop sustained release nanoencapsulated emulgel for potential use in osteoarthritis (OA).
      Methods: Chitosan (CHS) and chondroitin sulphate (CS) were employed as natural anti-inflammatory polymers to encapsulate nanoformulation of DCR. Optimised nanoformulation was prepared and characterised by investigating impact of polymers and surfactant on particle size, PDI, and encapsulation efficiency (EE). Afterwards, nanoemulgel of optimised DCR-NPs was formulated and evaluated for transdermal application.
      Results: Optimised nanoformulation depicted spherical shape with particle size of 320 nm having PDI and EE of 0.3 ± 0.07 and 82 ± 4% (w/w), respectively. DCR-nanoemulgel depicts sustained action of drug up to 96 h with enhanced permeation activity and non-irritancy index.
      Conclusions: The elaborated nanoemulgel sustained release of drug having superior penetration properties with provision of enhanced therapeutic effect owing to the presence of CHS, CS, and Argan oil possessing indelible anti-inflammatory attributes.
    • Contributed Indexing:
      Keywords: Diacerein; chitosan; chondroitin sulphate; nanoemulgel; sustained effect; transdermal delivery
    • الرقم المعرف:
      0 (Anthraquinones)
      0 (Anti-Inflammatory Agents)
      0 (Gels)
      0 (Polymers)
      4HU6J11EL5 (diacerein)
      9012-76-4 (Chitosan)
    • الموضوع:
      Date Created: 20200928 Date Completed: 20210906 Latest Revision: 20220331
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1080/02652048.2020.1829140
    • الرقم المعرف:
      32981415