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Modeling better in vitro models for the prediction of nanoparticle toxicity: a review.

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  • المؤلفون: Cao Y;Cao Y; Li S; Li S; Chen J; Chen J
  • المصدر:
    Toxicology mechanisms and methods [Toxicol Mech Methods] 2021 Jan; Vol. 31 (1), pp. 1-17. Date of Electronic Publication: 2020 Oct 12.
  • نوع النشر :
    Journal Article; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: London : Taylor and Francis, c2002-
    • الموضوع:
      Biological Assay* ; Toxicity Tests*; Nanoparticles/*toxicity; Animals ; Cell Communication ; Cell Culture Techniques ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cellular Microenvironment ; DNA Damage ; Endpoint Determination ; Humans ; Risk Assessment ; Tissue Culture Techniques
    • نبذة مختصرة :
      Exposure to nanoparticles (NPs) is plausible in real life due to ambient particulate exposure or development of nanotechnologies, hence the evaluation of NP toxicity as well as mechanism-based studies are necessary. The in vitro models allow rapid testing of NP toxicity, but it is required that the developed in vitro models are reliable to reflect the toxicity of NPs. In this review, we discussed the principles to model better in vitro models to predict the toxicity of NPs based on our own experiences and works of literature. We suggested that in vitro nanotoxicological studies should consider (1) using normal cells because the commonly used cancer cell lines might not reflect the toxicity of NPs to normal tissues; (2) the possible influence of biological molecules to reflect the toxicity of NPs in a biological microenvironment; (3) the influence of pathophysiological conditions to mimic the responses of NPs under different in vivo conditions; and (4) developing advanced tissue-based models to reflect the responses of tissues/organs to NPs. It is our hope that this review may provide useful information for the future design of in vitro nanotoxicological studies.
    • Contributed Indexing:
      Keywords: in vitro models; Nanoparticles (NPs); advanced tissue-based cultures; toxicity
    • الموضوع:
      Date Created: 20200925 Date Completed: 20210331 Latest Revision: 20210331
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1080/15376516.2020.1828521
    • الرقم المعرف:
      32972312