A genome-wide association study revealed five SNPs affecting 8-month weight in sheep.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8605704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2052 (Electronic) Linking ISSN: 02689146 NLM ISO Abbreviation: Anim Genet Subsets: MEDLINE

Publication: Oxford, England : Wiley-Blackwell
Original Publication: Oxford, England : Published by Blackwell Scientific Publications for the International Society for Animal Blood Group Research, c1986-

Polymorphism, Single Nucleotide*; Body Weight/*genetics ; Genetic Association Studies/*veterinary ; Sheep, Domestic/*genetics; Animals ; Breeding ; Female ; Iran ; Phenotype ; Pregnancy ; Red Meat ; Sheep, Domestic/growth & development

Lamb weight at 8 months of age is an important trait in the sheep industry in terms of the onset of puberty around this age; however, knowledge of its effective genetic factors is limited. Therefore, a GWAS using the 50K SNP-Chip was performed on 96 Baluchi sheep to identify the genomic regions associated with 8-month weight. The results of the present study revealed five SNPs on chromosomes 4, 14 and 16 at 5% chromosome-wide significance level, jointly accounting for 0.95% of total genetic variance. Four genes - MTPN, HYDIN, LRGUK and ZFP90 - were found in 50 kb intervals around the significant SNPs, of which MTPN is involved in regulation of skeletal muscle growth. Our results may provide a new vision to identify the genomic regions affecting growth traits in sheep.
(© 2020 Stichting International Foundation for Animal Genetics.)

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Keywords: GWAS; body weight; candidate gene; sheep

Date Created: 20200910 Date Completed: 20210323 Latest Revision: 20210323

20240628

10.1111/age.12996

32910467