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The effects of 1-methylnaphthalene after inhalation exposure on the serum corticosterone levels in rats.
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- المؤلفون: Świercz R;Świercz R; Stępnik M; Stępnik M
- المصدر:
International journal of occupational medicine and environmental health [Int J Occup Med Environ Health] 2020 Sep 17; Vol. 33 (5), pp. 691-699. Date of Electronic Publication: 2020 Jul 27.
- نوع النشر :
Journal Article
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: Nofer Institute of Occupational Medicine Country of Publication: Poland NLM ID: 9437093 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1896-494X (Electronic) Linking ISSN: 12321087 NLM ISO Abbreviation: Int J Occup Med Environ Health Subsets: MEDLINE
- بيانات النشر:
Publication: 2015- : Lodz : Nofer Institute of Occupational Medicine
Original Publication: Lodz : Nofer Institute of Occupational Medicine ; Polish Association of Occupational Medicine, [1994-
- الموضوع:
- نبذة مختصرة :
Objectives: This paper reports on the trend of the stressogenic stimulus caused by a repeated exposure to 1-methylnaphthalene (1-MN) vapors at the nominal concentrations of 0 mg/m 3 (the control restrainer), 50 mg/m 3 or 200 mg/m 3 in the nose-only inhalation system, by analyzing the serum corticosterone (CORT) levels in rats.
Material and Methods: Three groups of rats were exposed in restrainers to 1-MN vapors at the nominal concentrations of 0 mg/m 3 , 50 mg/m 3 or 200 mg/m 3 for 5 days. One control group of animals spent all the time during the experiment in an individually ventilated plastic cage. The serum CORT concentrations were determined in all 4 groups of the rats. The blood samples drawn from the tail vein were collected every day after termination of the 6-h exposure. On the fifth day, blood samples were collected 15 min, 30 min, 45 min, 1 h, and 3 h after termination of the 6-h exposure.
Results: On the fifth day of the study, no statistically significant changes in body weights between all groups of animals were found. After 5 days of the observation, increased food intake in the control groups was noted. Significantly higher CORT concentrations in the rats exposed to 1-MN at 200 mg/m 3 and in the animals from the control restrainer were found, comparing to the animals exposed to 1-MN at 50 mg/m 3 and the animals from the control cage.
Conclusions: The application of 6-h restraining induced high concentrations of the stress hormone, CORT, in the blood of rats. The short-term exposure of rats to 1-MN non-linearly reduced the restraint stress measured with CORT concentration. Int J Occup Med Environ Health. 2020;33(5):691-9.
(This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.)
- Contributed Indexing:
Keywords: 1-methylnaphthalene; HPA; corticosterone; inhalation exposure; rat; restraining stress
- الرقم المعرف:
0 (Air Pollutants)
0 (Biomarkers)
0 (Naphthalenes)
W980KJ009P (Corticosterone)
- الموضوع:
Date Created: 20200818 Date Completed: 20210316 Latest Revision: 20221222
- الموضوع:
20231215
- الرقم المعرف:
10.13075/ijomeh.1896.01476
- الرقم المعرف:
32801368
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