Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Triticum*; Gastric Mucosa/*blood supply ; Gastritis/*prevention & control ; Peptides/*pharmacology ; Protective Agents/*pharmacology; Animals ; Anti-Inflammatory Agents/pharmacology ; Cytokines/metabolism ; Dinoprostone/metabolism ; Disease Models, Animal ; Endothelin-1/metabolism ; Ethanol/adverse effects ; Gastric Mucosa/drug effects ; Gastritis/chemically induced ; Male ; Microcirculation/drug effects ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Omeprazole/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Trefoil Factors/metabolism ; Vasodilation/drug effects

Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives are considered for relieving the progression of gastric mucosal lesions instead of conventional drugs that produce side effects. This study was designed to evaluate the gastroprotective effects and investigate the defensive mechanisms of wheat peptides against ethanol-induced acute gastric mucosal injury in rats. Sixty male Sprague-Dawley rats were divided into six groups and orally treated with wheat peptides (0.1, 0.2, 0.4 g/kgbw) and omeprazole (20 mg/kgbw) for 4 weeks, following absolute ethanol administration for 1 h. Pretreatment with wheat peptides obviously enhanced the vasodilation of gastric mucosal blood vessels via improving the gastric mucosal blood flow and elevating the defensive factors nitric oxide (NO) and prostaglandin E2 (PGE2), and lowering the level of vasoconstrictor factor endothelin (ET)-1. Wheat peptides exhibited anti-inflammatory reaction through decreasing inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, and increasing trefoil factor 1 (TFF1) levels. Moreover, wheat peptides significantly down-regulated the expression of phosphorylated nuclear factor kappa-B (p-NF-κB) p65 proteins in the NF-κB signaling pathway. Altogether, wheat peptides protect gastric mucosa from ethanol-induced lesions in rats via improving the gastric microcirculation and inhibiting inflammation mediated by the NF-κB signaling transduction pathway.

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Keywords: gastric mucosal blood flow; gastroprotection; inflammation; nuclear factor kappa B; wheat peptides

0 (Anti-Inflammatory Agents)
0 (Cytokines)
0 (Endothelin-1)
0 (NF-kappa B)
0 (Peptides)
0 (Protective Agents)
0 (Trefoil Factors)
31C4KY9ESH (Nitric Oxide)
3K9958V90M (Ethanol)
EC 1.14.13.39 (Nitric Oxide Synthase)
K7Q1JQR04M (Dinoprostone)
KG60484QX9 (Omeprazole)

Date Created: 20200814 Date Completed: 20210318 Latest Revision: 20210318

20231215

PMC7469019

10.3390/nu12082355

32784583