Diagnostic value of HR-MRI and DCE-MRI in unilateral middle cerebral artery inflammatory stenosis.

Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

Original Publication: Hoboken, NJ : John Wiley & Sons

Contrast Media* ; Middle Cerebral Artery*/diagnostic imaging; Blood-Brain Barrier ; Constriction, Pathologic/diagnostic imaging ; Humans ; Magnetic Resonance Imaging

Purpose: High-resolution magnetic resonance imaging (HR-MRI) has high spatial resolution and can simultaneously perform wall and lumen imaging. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can evaluate the integrity of the blood-brain barrier. In this paper, the result of 3.0T HR-MRI and 3.0T DCE-MRI has been evaluated to explore the application value of unilateral middle cerebral artery inflammatory stenosis and changes in vascular permeability parameters of stroke events.
Methods: Thirty-six cases of neurological suspicion of central nervous system vasculitis of our hospital were selected from 20 January 2018 to 1 January 2019, who were diagnosed as unilateral middle cerebral artery M1 stenosis/occlusion by 3D TOF MRA. 3.0T HR-MRI and 3.0T DCE-MRI has been applied.
Results: Among the 36 patients who met the inclusion criteria, 23 patients with central nervous system vasculitis were diagnosed. The 23 patients with HR-MRI showed diffuse thickening and enhanced stenosis. The K ^trans value of 10/23 patients with acute-subacute cerebral infarction and 3/23 patients in chronic phase were significantly higher than that of the mirror side, and the K ^trans value of these patients remeasured in the same region of interest is lower than before after 6 months treatment. The K ^trans value in the target area of 10 patients without cerebrovascular events was not statistically significant compared with the mirror side. The K ^trans value of patients with acute-subacute cerebral infarction was significantly higher than that without cerebrovascular events (0.098 ± 0.038 vs. 0.007 ± 0.001, p = .000), and there was no significant difference between K ^trans in the chronic infarction group and the other two groups (0.098 ± 0.038 vs. 0.044 ± 0.012, p = .058; 0.044 ± 0.012 vs. 0.007 ± 0.001, p = .057).
Conclusion: HR-MRI is an accurate direct imaging method and has a high value for the etiological diagnosis of central nervous system vasculitis. DCE-MRI could be an effective way to evaluate and monitor blood-brain barrier to prevent clinical ischemic stroke.
(© 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)

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Keywords: DCE-MRI; HR-MRI; blood-brain barrier; central nervous system vasculitis

0 (Contrast Media)

Date Created: 20200809 Date Completed: 20210624 Latest Revision: 20210624

20250114

PMC7507039

10.1002/brb3.1732

32767660