COVID-19, Virology and Geroscience: A Perspective.

Publisher: Serdi Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE

Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co.,

Aging*/immunology ; Aging*/pathology ; Betacoronavirus* ; Geriatrics* ; Virology*; Coronavirus Infections/*epidemiology ; Coronavirus Infections/*virology ; Pneumonia, Viral/*epidemiology ; Pneumonia, Viral/*virology; Aged ; COVID-19 ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Pandemics ; SARS-CoV-2

A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019. The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease 2019 (COVID-19). Older adults have higher peak of viral load and, especially those with comorbidities, had higher COVID-19-related fatality rates than younger adults. In this Perspective paper, we summarize current knowledge about SARS-CoV-2 and aging, in order to understand why older people are more affected by COVID-19. We discuss about the possibility that the so-called "immunosenescence" and "inflammaging" processes, already present in a fraction of frail older adults, could allow the immune escape of SARS-CoV-2 leading to COVID-19 serious complications. Finally, we propose to use geroscience approaches to the field of COVID-19.
Competing Interests: The authors declare no conflict of interest

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Keywords: COVID-19; SARS-CoV-2; aging; coronavirus; frailty; geroscience; prevention

Date Created: 20200804 Date Completed: 20200810 Latest Revision: 20240822

20240822

PMC7301052

10.1007/s12603-020-1416-2

32744561