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Baru Pulp ( Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI, 2011-
    • الموضوع:
      Antioxidants/*pharmacology ; Caenorhabditis elegans/*metabolism ; Caenorhabditis elegans Proteins/*metabolism ; Dipteryx/*chemistry ; Forkhead Transcription Factors/*metabolism ; Fruit/*chemistry ; Oxidative Stress/*drug effects ; Superoxide Dismutase/*metabolism; Animals ; Animals, Genetically Modified ; Antioxidants/isolation & purification ; Brazil ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Chromatography, Liquid/methods ; Forkhead Transcription Factors/genetics ; Grassland ; Life Expectancy ; Longevity/drug effects ; Mass Spectrometry/methods ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Superoxide Dismutase/genetics
    • نبذة مختصرة :
      Fruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit Dipteryx alata ; evaluate its toxic effects, influence on the life expectancy of the nematode Caenorhabditis elegans , and its antioxidant activities in vitro and in vivo ; and describe the mechanisms involved. The chemical compounds identified include phenols, terpenes, fatty acid derivatives, vitamins, and a carboxylic acid. The in vitro antioxidant activity was demonstrated by radical scavenging methods. In vivo , the D. alata fruit pulp was not toxic and promoted resistance to oxidative stress in nematodes exposed to a chemical oxidizing agent. Furthermore, it promoted an increased life expectancy in wild-type nematodes and increased the expression of superoxide dismutase and the nuclear translocation of DAF-16. These results suggest that the beneficial effects identified are related to these two genes, which are involved in the regulation of metabolic activities, the control of oxidative stress, and the lifespan of C. elegans . These beneficial effects, which may be related to its chemical constituents, demonstrate its potential use as a functional and/or nutraceutical food.
      Competing Interests: The authors declare that there are no conflicts of interest.
    • References:
      Exp Gerontol. 2018 Jul 1;107:136-139. (PMID: 28797825)
      Nutrition. 2018 Nov;55-56:154-160. (PMID: 30086484)
      Mol Cell. 2016 Apr 7;62(1):63-78. (PMID: 27052732)
      Mech Ageing Dev. 2019 Jan;177:4-21. (PMID: 30134144)
      J Agric Food Chem. 2010 Jul 28;58(14):8139-44. (PMID: 20583841)
      Electrophoresis. 2014 Jun;35(11):1571-81. (PMID: 24658881)
      Methods. 2014 Aug 1;68(3):450-7. (PMID: 24780523)
      Prog Lipid Res. 2018 Apr;70:62-93. (PMID: 29679619)
      Free Radic Biol Med. 2015 Nov;88(Pt B):290-301. (PMID: 26232625)
      Food Chem Toxicol. 2013 Aug;58:255-63. (PMID: 23643700)
      Comp Biochem Physiol B Biochem Mol Biol. 2014 Apr;170:26-32. (PMID: 24472780)
      PeerJ. 2016 Apr 07;4:e1879. (PMID: 27077003)
      Molecules. 2010 Nov 12;15(11):8193-204. (PMID: 21076386)
      Food Res Int. 2018 Jan;103:345-360. (PMID: 29389624)
      Semin Cancer Biol. 2017 Oct;46:84-106. (PMID: 28676460)
      Molecules. 2013 Feb 19;18(2):2328-75. (PMID: 23429347)
      Mech Ageing Dev. 2018 Apr;171:47-57. (PMID: 29526449)
      Free Radic Biol Med. 2017 Jul;108:362-373. (PMID: 28392283)
      Sci Total Environ. 2018 Apr 1;619-620:1-8. (PMID: 29136530)
      Food Chem Toxicol. 2018 Oct;120:639-650. (PMID: 30077708)
      J Am Soc Mass Spectrom. 2001 Jun;12(6):707-15. (PMID: 11401161)
      Trends Pharmacol Sci. 2017 Jul;38(7):592-607. (PMID: 28551354)
      Exp Gerontol. 2015 Dec;72:1-7. (PMID: 26363351)
      Cancer Lett. 2018 Apr 28;420:129-145. (PMID: 29408515)
      Phytomedicine. 2019 Mar 1;55:200-213. (PMID: 30668430)
      Exp Ther Med. 2015 May;9(5):1819-1826. (PMID: 26136899)
      Oxid Med Cell Longev. 2018 Jul 4;2018:9241308. (PMID: 30116496)
      PLoS One. 2014 Mar 03;9(3):e89933. (PMID: 24594796)
      Food Chem. 2018 Apr 15;245:1148-1153. (PMID: 29287334)
      Clin Chim Acta. 2014 Sep 25;436:332-47. (PMID: 24933428)
    • Contributed Indexing:
      Keywords: C. elegans; antioxidant; fruit native; nutraceutical food; protects effects
    • الرقم المعرف:
      0 (Antioxidants)
      0 (Caenorhabditis elegans Proteins)
      0 (Forkhead Transcription Factors)
      0 (Plant Extracts)
      0 (daf-16 protein, C elegans)
      EC 1.15.1.1 (Sod-3 protein, C elegans)
      EC 1.15.1.1 (Superoxide Dismutase)
    • الموضوع:
      Date Created: 20200730 Date Completed: 20210308 Latest Revision: 20210308
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC7463619
    • الرقم المعرف:
      10.3390/biom10081106
    • الرقم المعرف:
      32722431