Complex Virome in a Mesenteric Lymph Node from a Californian Sea Lion ( Zalophus Californianus) with Polyserositis and Steatitis.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Virome*; Lymph Nodes/*pathology ; Lymph Nodes/*virology ; Sea Lions/*virology ; Serositis/*pathology ; Serositis/*veterinary ; Steatitis/*pathology; Anelloviridae/classification ; Anelloviridae/isolation & purification ; Animals ; Animals, Wild ; California ; Female ; Inflammation ; Metagenomics ; Parvovirus/classification ; Parvovirus/isolation & purification ; Polyomavirus/classification ; Polyomavirus/isolation & purification ; Serositis/virology ; Steatitis/virology

An emaciated subadult free-ranging California sea lion (Csl or Zalophus californianus) died following stranding with lesions similar to 11 other stranded animals characterized by chronic disseminated granulomatous inflammation with necrotizing steatitis and vasculitis, involving visceral adipose tissues in the thoracic and peritoneal cavities. Histologically, affected tissues had extensive accumulations of macrophages with perivascular lymphocytes, plasma cells, and fewer neutrophils. Using viral metagenomics on a mesenteric lymph node six mammalian viruses were identified consisting of novel parvovirus, polyomavirus, rotavirus, anellovirus, and previously described Csl adenovirus 1 and Csl bocavirus 4. The causal or contributory role of these viruses to the gross and histologic lesions of this sea lion remains to be determined.

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Keywords: California sea lion; Zalophus californianus; granulomatous; next-generation sequencing; perivascular; polyomavirus; polyserositis; protoparvovirus; steatitis; vasculitis; virome

Date Created: 20200729 Date Completed: 20210226 Latest Revision: 20210226

20250114

PMC7472147

10.3390/v12080793

32718049