Prenatal Exposures to Perfluoroalkyl Acids and Associations with Markers of Adiposity and Plasma Lipids in Infancy: An Odense Child Cohort Study.

Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-9924 (Electronic) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE

Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.

Adiposity/*physiology ; Environmental Pollutants/*blood ; Fluorocarbons/*blood ; Maternal Exposure/*statistics & numerical data; Adult ; Alkanesulfonic Acids ; Caprylates ; Child ; Cohort Studies ; Decanoic Acids ; Fatty Acids ; Female ; Humans ; Infant ; Male ; Obesity ; Plasma ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prospective Studies ; Sulfonic Acids

Background: Perfluoroalkyl acids (PFAA) are repellants that cross the placental barrier, enabling interference with fetal programming. Maternal PFAA concentrations have been associated with offspring obesity and dyslipidemia in childhood and adulthood, but this association has not been studied in infancy.
Objectives: We investigated associations between maternal PFAA concentrations and repeated markers of adiposity and lipid metabolism in infancy.
Methods: In the prospective Odense Child Cohort, maternal pregnancy serum concentrations of five PFAA: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 649 women. Offspring were examined at birth ( n = 613 ) and at 3 months ( n = 602 ) and 18 months ( n = 503 ) of age. Total cholesterol, LDL, HDL, and triglyceride were evaluated at 3 months ( n = 262 ) and 18 months ( n = 198 ) of age. Mixed effects linear regression models estimated associations between PFAA and standardized (SDS) body mass index (BMI), ponderal index, and waist circumference. Associations between PFAA and body fat% (BF%) and plasma lipids SDS at 3 months and 18 months of age were investigated with linear regression models.
Results: PFNA and PFDA were associated with higher BMI SDS [adjusted β = 0.26 ; 95% confidence interval (CI): 0.03, 0.49 and β = 0.58 ; 95% CI: - 0.03 , 1.19, respectively, for 1 -ng / mL increases] and ponderal index SDS ( β = 0.36 ; 95% CI: 0.13, 0.59 and β = 1.02 ; 95% CI: 0.40, 1.64, respectively) at 3 and 18 months of age (pooled) in girls. Corresponding estimates for boys were closer to the null but not significantly different from estimates for girls. In boys and girls (combined), PFNA and PFDA were associated with BF% at age 3 months (for 1 -ng / mL PFDA, β = 0.40 ; 95% CI: 0.04, 0.75), and PFDA was associated with total cholesterol SDS at 18 months ( β = 1.06 ; 95% CI: 0.08, 2.03) ( n = 83 ).
Discussion: Prenatal PFAA were positively associated with longitudinal markers of adiposity and higher total cholesterol in infancy. These findings deserve attention in light of rising rates of childhood overweight conditions and dyslipidemia. https://doi.org/10.1289/EHP5184.

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0 (Alkanesulfonic Acids)
0 (Caprylates)
0 (Decanoic Acids)
0 (Environmental Pollutants)
0 (Fatty Acids)
0 (Fluorocarbons)
0 (Sulfonic Acids)
335-76-2 (perfluorodecanoic acid)
375-95-1 (perfluoro-n-nonanoic acid)
947VD76D3L (perfluorooctanoic acid)
9H2MAI21CL (perfluorooctane sulfonic acid)
FX3WJ41CMX (perflexane)

Date Created: 20200707 Date Completed: 20201209 Latest Revision: 20211204

20221213

PMC7338787

10.1289/EHP5184

32628516